DOC HARRIS":3vc6g165 said:
The enhancement of EPD's and verification of EPD Accuracies by the use of DNA-Marker Technology has "Leap-Frogged" Trait and Characteristic awareness through the expedient use of Molecular Value Predictions (MVP's). The tremendous scientific and accurate incorporation of these DNA Markers relating to Feed Efficiency, Marbling and Tenderness has opened a wide door to additional methods of providing reliable information for producers to utilize in making breeding decisions.
DOC HARRIS
didn't see in the article where this was used or reported. jerry taylor says in meetings the 50K chip is worthless across breeds.
my beef with the markers is people won't reveal homo or heterostate and which is better and what is the relative contribution and what their verified contribution in isolation or what the relative combinations tested were. you can ask them till you are blue in the face and they won't tell you squat. even data out that the orginal tenderness markers don't work across breeds. relatively little data on following markers through till slaughter with an independent test or any availability to test one's own cattle and test for shear force and do minimal verification of impact of markers.
data is not revealed on marker selection, particularly across breeds. just as sequencing the human genome was supposed to help cure disease, the promise of markers is not nigh.
relatively complete sequencing including sequencing of the mRNA's would be interesting in that one could get both alleles and the sequence of the mRNA and check for SNP's from both strands as the nucleic acid moves from genomic to protein. protein sequencing is still way to expensive. i used to be on this molecular bandwagon but not anymore.
pacific biosciences or similar company may change the landscape. too many things outside gene region is responsible for expression and may interfere with having a snp associated with a trait but it's regulation is not. it's pretty apparent, and obviously to the marker companies, these traits are multifactorial and are only beginning to understand how to deal with all the data necessary after the days of the easy low hanging fruit are over and mostly associated with single gene recessive defects.