The bolus is what I use and protects against E. coli and coronavirus, generally $7 per bolus if you buy the 30 pack. The Tri Shield paste also protects against rotavirus and is around $15 per tube/dose.
I used to vaccinate with Scour Bos prior to calving years ago, but then spring calving segued into primarily spring, with about a third lagging into fall. So I stopped. And then got spanked with scours one year. Tried the First Defense the next year and I was a believer; haven't had to treat for scours in years. That said, I'm back to a relatively short spring calving again and could easily go back to vaccinating prior to calving, but gathering them up & working them in potentially nasty weather is not appealing. Plus, I need help to do that. Picking my battles and popping in a bolus day 1, when I tag & give Inforce 3. And THAT said, I moved calving back a few weeks (trying to miss brutal weather) and most of the herd is calving out in the clean pasture. If I'm unable to give a calf the bolus, especially if it's from an older cow with quality teats & colostrum, I make note of it, but rarely have a problem. First calf heifers are a different story. I calve them out in the barn and their calves get a bolus, no exceptions.