Bird dog--that all depends on what plant species one is trying to control. Biggest problems come from differsnt species that begin to grow at different soil temps and different day lengths. Goatweed is a hot weather plant that comes on after my other invasive-Chinese allow. If I wait for the goatweed, I won't be spraying until mid June or (this year--now) , but by then, the Tallow is already several feet in height.
Also, if the species is a woody brush, (or trees like young sweetgum, Chinese Tallow, & Greenbriar) in spite of what specimen labels say, the best result is achieved in early fall, at the end of the growing season. For me, that is late Aug thru Sept and into early Oct. The sap is beginning to move down into the plant's root system to store energy for winter dormancy, and the best results are spraying woody brush during that period, just before the leaves turn colors. Yes, I know that is exactly opposite of what almost all specimen labels state....but,
As a rep from a major herbicide company once privately confided to me-"We aren't really in the business of killing trees, weeds, and brush--we're in the business of selling herbicide, and the more times you have to spray, the more we will sell."
Your Snow on the Mountain is what we call Bishop's Weed around here. Thankfully, it isn't a big problem in my area.