To sum up: IMO, Alpha 7 offers the best clostridial protection available bar none, and does it in one shot.
I have used Alpha 7 and experenced the knot thing too. :roll:
My advice, worth what you paid for it is, if you want to work calves once and be done with it, use Alpha 7.
If you plan to work calves again in 4-6 months anyway, use a cheaper water based 7 way and give a booster shot later.
IMO, Vision 7 is a good second choice. Also available with pinkeye protection. Vision 7 offers no knots and only a 2cc dose is required. But Vision 7 should be boosted.
Vision 7 usuallly costs a bit more than common 5cc dose 7 ways, but not as much as Alpha 7.