On November 26, 1982, he fought champion Larry Holmes for the WBC World Heavyweight title at Houston's Astrodome. Cobb was defeated in a unanimous decision by Holmes, who won all 15 rounds on two of three scorecards. The bloody one-sidedness of the fight, which came 13 days after the bout between Ray Mancini and Duk Koo Kim that led to Kim's death four days later due to brain trauma, so horrified sportscaster Howard Cosell that he vowed never to cover another professional match, which Cobb jokingly referred to as his "gift to the sport of boxing." His sense of humor was revealed when he was asked if he would consider a rematch, to which he replied that he did not think that Holmes would agree, as Holmes' "hands could not take it." In an interview after the Holmes fight he was asked how he could fight someone whose arms were a foot longer than his were, to which he replied, "Oh, it seemed that way to you too?"