We worm calves the first time that they come through the corral for roundup, which is usually 4 to 6 months of age. We "work" all the cattle twice per year. New arrivals (purchases or trades, not newborns) of any gender get dewormed and vaccinated. If the calves you are asking about are grazing, and you have the opportunity you can worm them earlier if you feel it is necessary. We generally use a pour-on wormer in the spring (seems to help with flies, ticks, grubs, lice, etc. for a few weeks) and an injectable in the fall.