Thanks Frankie. Already knew most of that information though. I wouldnt be looking into high percentage bison. I was actually even looking at a percentage less than the Beefalo breed are. But if I had to do it myself then yes I would have to start from scratch and all those problems would have to be faced. Most of the things I've heard from breeders who have done it, is that you can only breed a bison cow with a beef bull, not the other way around. Also, that all the male animals will come in sterile, which I am ok with. As long as the females were fertile and could be bred to a beef bull again.
In the end i have more research to do, but if it worked you would have the cheapest beef animal around im sure!!!