Ranchers in Texas Need to Pay Close Attention to CWD TSE Prion

[flounder]

TPWD Executive Order No. 23-003 CWD Emergency Rules Adopted for Movement of Breeder Deer

Executive Orders

2023

Executive Order No. 23-003

Date: July 24, 2023

The Executive Director finds that additional discoveries of CWD in free-ranging white-tailed deer within deer breeding facilities regulated under Parks and Wildlife Code, Chapter 43, Subchapter L and regulations adopted pursuant to that subchapter (31 TAC Chapter 65, Subchapters B and T) constitute an immediate danger to the white-tailed deer and mule deer resources of Texas and that the adoption of rules on an emergency basis with fewer than 30 days' notice is necessary to address an immediate danger.

https://tpwd.texas.gov/publications/executive_orders/

Emergency Rules Adopted for Movement of Breeder Deer

July 25, 2023

Media Contact: TPWD News, Business Hours, 512-389-8030

AUSTIN — In response to continued positive detections of Chronic Wasting Disease (CWD) in deer breeding facilities, Texas Parks and Wildlife Department (TPWD) has adopted an emergency rule implementing additional movement and testing restrictions for white-tailed deer in deer breeding facilities.

Since June, TPWD has received confirmation of CWD in deer breeding facilities in three counties- Brooks, Frio and Zavala. In 2023 alone, CWD has been detected in nine deer breeding facilities in seven counties. A total of 14 counties have had positive detections since March 2021.

"Since 2021, we have seen an increase in CWD detections from breeder deer at an unprecedented rate," said John Silovsky, Wildlife Division Director for TPWD. "It's our hope that these emergency rules will strengthen our surveillance and reduce the number of CWD positive detections across the state."

This emergency order amends Chapter 31 TAC §65.95, relating to Movement of Breeder Deer. The change requires all breeder deer to be ante-mortem (live-animal) tested for CWD (with a test result of "Not Detected") before transferring to another deer breeding facility or release site. These changes will be in effect for 120 days but may be extended an additional 60 days.

Additionally, the department has determined that to expedite and facilitate epidemiological investigations, it is necessary to prohibit the removal of identification tags under any circumstance other than allowed by statute. The ability to quickly locate and test breeder deer transferred to a release facility is critical to determining the likelihood of disease transmission.

CWD is a fatal neurological disease found in certain cervids including deer, elk, moose and other members of the deer family. This slow, progressive disease may not produce visible signs in susceptible species for several years after infection. As the irreversible disease process continues, animals with CWD may show changes in behavior and appearance. Clinical signs may include progressive weight loss, stumbling or tremors with a lack of coordination, loss of appetite, teeth grinding, abnormal head posture and/or drooping ears, and excessive thirst, salivation or urination.

Visit TPWD's recently updated CWD page to find a map of all CWD zones, check stations and positive case tracking. The site also provides answers to frequently asked questions, videos with information from wildlife veterinarians, best management practices for hunters and landowners and review the latest news.

https://tpwd.texas.gov/newsmedia/releases/?req=20230725a

Executive Orders

2023

Executive Order No. 23-003

Date: July 24, 2023

Under the provisions of Parks and Wildlife Code, §12.027, if the Texas Parks and Wildlife Commission (the Commission) or the Executive Director of the Texas Parks and Wildlife Department (Executive Director) finds that there is an immediate danger to a species authorized to be regulated by the Department, the Commission or the Executive Director may adopt emergency rules as provided by Government Code, §2001.034.

White-tailed deer and mule deer are game animals subject to regulation by the Commission under the provisions of various chapters of the Parks and Wildlife Code, including Chapters 43 (Subchapters E, L, R, and R-1), 61, 62, and 63. Chronic Wasting Disease (CWD) is a fatal neurodegenerative disorder that affects some cervid species, including white-tailed deer and mule deer.

The Executive Director finds that additional discoveries of CWD in free-ranging white-tailed deer within deer breeding facilities regulated under Parks and Wildlife Code, Chapter 43, Subchapter L and regulations adopted pursuant to that subchapter (31 TAC Chapter 65, Subchapters B and T) constitute an immediate danger to the white-tailed deer and mule deer resources of Texas and that the adoption of rules on an emergency basis with fewer than 30 days' notice is necessary to address an immediate danger.

The emergency rules require all breeder deer to be tested for CWD (with a test result of "Not Detected") by means of an approved ante-mortem (live-animal) test as a condition of transfer to another deer breeding facility and expressly prohibit the removal of an identification tag prescribed by Parks and Wildlife Code, §43.3561, from a breeder deer except to immediately replace it with an identification tag meeting the requirements of Parks and Wildlife Code, §43.3561(c) or (h).

Therefore, finding that the immediate danger to both captive and free-ranging white-tailed and mule deer populations exists, the Executive Director hereby ORDERS the adoption, on an emergency basis, of an amendment to 31 TAC §65.95, concerning Movement of Breeder Deer, and §65.611 (relating to Prohibited Acts), in response to the ongoing and most recent detections of chronic wasting disease (CWD) in additional deer breeding facilities.

This order is effective immediately upon filing, and authorizes publication of a Notice of Extension of Emergency Adoption in the Texas Register.

This order is issued pursuant to §12.027 of the Texas Parks and Wildlife Code and §2001.034 of the Texas Government Code and is effective immediately.

Signed this 24th day of July, 2023.

https://tpwd.texas.gov/publications/executive_orders/

see full text and more here;

WEDNESDAY, JULY 26, 2023

TPWD Executive Order No. 23-003 CWD Emergency Rules Adopted for Movement of Breeder Deer

https://chronic-wasting-disease.blogspot.com/2023/07/tpwd-executive-order-no-23-003-cwd.html

 

[TexasJerseyMilker]

Seems to me that these deer farms breed deer with freakishly large and branching antlers that they sell for canned hunts. What a sport to shoot tame deer. Its like going out in the pasture and shooting someone's prize bull. What about the possibly infected brains ans spinal cords of these canned hunt deer? What happenes to those?

We were just talking today, as much as we love Texas we are glad we left.
No fire ants here, no mesquite, no feral hogs, the Oregon countryside not overrun with yankees and Californians. Instead, bears and lions. We were carrying tools and lumber up the mountain today to fix the spring box. A big black round bodied animal was up the hill with it;s head down. A bear? No, it was a black bull, we were glad to see him swish his tail.

 

[M.Magis]

First off, you're responding to a troll. Second, those deer are anything but tame. Many are far more scared of humans than most unfenced deer. Not all mind you, but they sure aren't tame. Third, CWD has been known about in wild animals for 50+ years. To say it's been overblown is an understatement to say the least.

 

[Ebenezer]

First off, you're responding to a troll. Second, those deer are anything but tame. Many are far more scared of humans than most unfenced deer. Not all mind you, but they sure aren't tame. Third, CWD has been known about in wild animals for 50+ years. To say it's been overblown is an understatement to say the least.

It's like so much of the "control mentality" rather than an effort to eradicate and/or cure the problem. All of these regulations seem like a bandaide for a heart attack if the disease is constantly in the wild populations and never decreased or the range decreased. But DNR folks like to do this kind of stuff. They keep saying that the deer population in SC is dropping but nobody who farms can see anything other than more deer. less hunters and higher processing costs if you can get deer into a processor. So DNR has dropped the limits in recent years and that only increases the problem.

The disconnect for me has always been that the wildlife belong to the state. But the state is never liable for car repair, crop damage and such. Same thing for federally protected birds that destroy fruit, crops, livestock - it's OK for them but not great for the folks who own things and get the damages.

 

[TexasJerseyMilker]

I've seen those penned deer. They just stand there looking at you.

I'm not arguing about it, but how is a member with 1026 posts that been around 17 years a troll? Usually trolls post once and disappear. He's not making stuff up or expressing his opinion. According to post history below is trying to be helpful.

I find the articles interesting. Such as this one. I was a veterinary nurse before I was a human nurse..
Transmission of cervid prions to humanized mice demonstrates the zoonotic potential of CWD

 

[flounder]

First off, you're responding to a troll. Second, those deer are anything but tame. Many are far more scared of humans than most unfenced deer. Not all mind you, but they sure aren't tame. Third, CWD has been known about in wild animals for 50+ years. To say it's been overblown is an understatement to say the least.

cwd population declines

CWD poses a significant threat to the future of hunting in Texas. Deer population declines of 45 and 50 percent have been documented in Colorado and Wyoming. A broad infection of Texas deer populations resulting in similar population impacts would inflict severe economic damage to rural communities and could negatively impact land markets. Specifically, those landowners seeking to establish a thriving herd of deer could avoid buying in areas with confirmed CWD infections. As they do with anthrax-susceptible properties, land brokers may find it advisable to inquire about the status of CWD infections on properties that they present for sale. Prospective buyers should also investigate the status of the wildlife on prospective properties. In addition, existing landowners should monitor developments as TPWD crafts management strategies to identify and contain this deadly disease.

Dr. Gilliland ([email protected]) is a research economist with the Texas Real Estate Research Center at Texas A&M University.

https://www.recenter.tamu.edu/articles/tierra-grande/oh-deer-2314

Colorado CWD TSE Prion Detected in 40 of 54 deer herds, 17 of 42 elk herds, and 2 of 9 moose herds

https://cpw.state.co.us/Documents/C...rtMillerWood_April2022-Matthew_Eckert-DNR.pdf

Colorado Chronic Wasting Disease Response Plan December 2018.

Executive Summary Mule deer, white-tailed deer, elk and moose are highly valued species in North America. Some of Colorado's herds of these species are increasingly becoming infected with chronic wasting disease(CWD).

As of July 2018, at least 31 of Colorado's 54 deer herds (57%), 16 of43 elk herds (37%), and 2 of 9 moose herds (22%) are known to be infected with CWD.

Four of Colorado's 5 largest deer herds and 2 of the state's 5 largest elk herds are infected.

Deer herds tend to be more heavily infected than elk and moose herds living in the same geographic area.

Not only are the number of infected herds increasing, the past 15 years of disease trends generally show an increase in the proportion of infected animals within herds as well.

Of most concern, greater than a 10-fold increase in CWD prevalence has been estimated in some mule deer herds since the early 2000s; CWD is now adversely affecting the performance of these herds.

snip...(the map on page 71, cwd marked in red, is shocking...tss)

https://cpw.state.co.us/Documents/RulesRegs/Brochure/BigGame/biggame.pdf

https://cpw.state.co.us/Documents/H...ColoradoChronicWastingDiseaseResponsePlan.pdf

Since identifying its first cases of CWD in captive deer in the 70s and finding the first wild infected deer in 1985, Wyoming has seen the disease slowly spread throughout the state. CWD has now been documented in members of the deer family in most of Wyoming's deer hunting areas, with 20% to 40% percent of mule deer affected in some herds. A 2017 study estimated a 21% annual population decline as a result of the fatal disease.

https://freerangeamerican.us/chroni...w been documented,result of the fatal disease.

How does CWD impact deer, elk, and moose populations?

Recent research in Wyoming has demonstrated declines in both mule and white-tailed deer populations in deer hunt area 65 due to CWD (see below for citations). These declines are in the core endemic area where prevalence is highest. In areas with lower prevalence, effects of CWD are poorly understood but are considered additive along with other factors that can negatively affect deer populations in Wyoming (i.e. habitat loss, predation, other diseases). The distribution and prevalence of CWD in Wyoming elk is less than that of deer. Currently there are no documented direct population impacts in Wyoming elk from CWD; however, research from Rocky Mountain National Park suggests that CWD could impact elk populations at higher prevalence (13%). While CWD has been found in free ranging moose, there have been few detections, and there is no evidence that CWD is currently having an impact on moose populations.

https://wgfd.wyo.gov/Wildlife-in-Wyoming/More-Wildlife/Wildlife-Disease/Chronic-Wasting-Disease

Colorado CWD figures just out; COLORADO CWD UPDATE

Notably, prevalence in the White River herd, one of the state's largest, rose from 15.3% to 23.6%.

Prevalence increased by about 10%, to 14%, in the Uncompahgre herd, and grew from 3.5% to 8% in the Middle Park herd.

Prevalence fell from 13.6% to 6.7% in the Sweetwater herd and from 12% to 8% in the Big Thompson herd.

Parks and Wildlife has detected the disease in 40 of Colorado's 54 deer herds, 17 of its 42 elk herds and two of its nine moose herds.

https://www.gjsentinel.com/news/wes...cle_3f3e09e2-321a-11ee-a836-bb106b337e90.html

WYOMING, POWELL — Sobering news resulting from a multi-year Chronic Wasting Disease (CWD) surveillance program by the Wyoming Game and Fish Department between 2018 and 2022 shows significant increases in the fatal disease for the state's prized mule deer and elk herds.

In one herd, the prevalence rate is calculated at 65% in mule deer bucks, and there are concerning increases in infected elk, including hunt areas popular for Big Horn Basin hunters.

The disease, which typically kills infected animals within two years after initial exposure, now occurs in 34 of Wyoming's 37 mule deer herds, and 15 of the state's 36 elk herd units.

https://www.wyomingnews.com/rocketm...cle_1005894a-361e-11ee-8900-0743386c0b87.html

terry

 

[flounder]

First off, you're responding to a troll. Second, those deer are anything but tame. Many are far more scared of humans than most unfenced deer. Not all mind you, but they sure aren't tame. Third, CWD has been known about in wild animals for 50+ years. To say it's been overblown is an understatement to say the least.

3.2.1.2 Non-cervid domestic species

The remarkably high rate of natural CWD transmission in the ongoing NA epidemics raises the question of the risk to livestock grazing on CWD-contaminated shared rangeland and subsequently developing a novel CWD-related prion disease. This issue has been investigated by transmitting CWD via experimental challenge to cattle, sheep and pigs and to tg mouse lines expressing the relevant species PrP.

For cattle challenged with CWD, PrPSc was detected in approximately 40% of intracerebrally inoculated animals (Hamir et al., 2005, 2006a, 2007). Tg mice expressing bovine PrP have also been challenged with CWD and while published studies have negative outcomes (Tamguney et al., 2009b), unpublished data provided for the purposes of this Opinion indicate that some transmission of individual isolates to bovinised mice is possible (Table 1).

In small ruminant recipients, a low rate of transmission was reported between 35 and 72 months post-infection (mpi) in ARQ/ARQ and ARQ/VRQ sheep intracerebrally challenged with mule deer CWD (Hamir et al., 2006b), while two out of two ARQ/ARQ sheep intracerebrally inoculated with elk CWD developed clinical disease after 28 mpi (Madsen-Bouterse et al., 2016). However, tg mice expressing ARQ sheep PrP were resistant (Tamguney et al., 2006) and tg mice expressing the VRQ PrP allele were poorly susceptible to clinical disease (Beringue et al., 2012; Madsen-Bouterse et al., 2016). In contrast, tg mice expressing VRQ sheep PrP challenged with CWD have resulted in highly efficient, life-long asymptomatic replication of these prions in the spleen tissue (Beringue et al., 2012).

A recent study investigated the potential for swine to serve as hosts of the CWD agent(s) by intracerebral or oral challenge of crossbred piglets (Moore et al., 2016b, 2017). Pigs sacrificed at 6 mpi, approximately the age at which pigs reach market weight, were clinically healthy and negative by diagnostic tests, although low-level CWD agent replication could be detected in the CNS by bioassay in tg cervinised mice. Among pigs that were incubated for up to 73 mpi, some gave diagnostic evidence of CWD replication in the brain between 42 and 72 mpi. Importantly, this was observed also in one orally challenged pig at 64 mpi and the presence of low-level CWD replication was confirmed by mouse bioassay. The authors of this study argued that pigs can support low-level amplification of CWD prions, although the species barrier to CWD infection is relatively high and that the detection of infectivity in orally inoculated pigs with a mouse bioassay raises the possibility that naturally exposed pigs could act as a reservoir of CWD infectivity.

3.2.1.3 Other species

Studies have demonstrated that the CWD agent(s) can be transmitted by the IC route in several species of rodents, such as voles (Subfamily Arvicolinae), deer mice (Peromyscus maniculatus), mice and hamsters (Subfamily Cricetinae). The susceptibility was, however, variable, being high in voles and deer mice but lower in mice and hamsters (Raymond et al., 2007; Heisey et al., 2010; Kurt et al., 2011; Di et al., 2013; Lee et al., 2013). Mink (subfamily Mustelinae) (Harrington et al., 2008), ferrets (Mustela putorius) (Bartz et al., 1998; Sigurdson et al., 2008) and cats (Mathiason et al., 2013) were susceptible to IC challenge with NA CWD sources, while CWD transmitted poorly to raccoons (Procyon lotor) by the IC route (Moore et al., 2019).

3.2.2 European isolates

https://efsa.onlinelibrary.wiley.com/doi/full/10.2903/j.efsa.2019.5863

CWD is highly infectious and very resistant to weather conditions and traditional disinfectants so it can remain in the environment for a long time. CWD can stick to soil particles for up to 10 years.

The only way to rapidly inactivate CWD's infectious agent is to soak clothes or equipment in a solution of bleach that has 20,000 parts per million of active chlorine, or 2 molar sodium hydroxide solution, for one hour.

This treatment will damage or destroy most clothing, footwear and hunting equipment.

https://www.gov.uk/guidance/chronic-wasting-disease

terry

 

[flounder]

First off, you're responding to a troll. Second, those deer are anything but tame. Many are far more scared of humans than most unfenced deer. Not all mind you, but they sure aren't tame. Third, CWD has been known about in wild animals for 50+ years. To say it's been overblown is an understatement to say the least.

"In addition, hay and straw from the United States and Canada must be accompanied by a certificate from a public veterinarian that the product has been harvested in states or provinces where Chronic Wasting Disease has not been detected on deer."

Regulation No. 1599 of 2018 on additional requirements for the import of hay and straw for used for animal feed.

This content is exclusively provided by

FAO, FAOLEX

Regulation No. 1599 of 2018 on additional requirements for the import of hay and straw for used for animal feed.

Country Norway

Type of law Regulation

Source

FAO , FAOLEX

Abstract

This Regulation seeks to prevent the spread of infectious animal diseases that can be caused by the importation of hay and straw used in animal feed from countries outside the European Economic Area. Hay and straw imported into Norway as animal feed must: (a) be accompanied by a confirmation from the manufacturer that the product has been stored for at least two months in the country of dispatch and harvested from farms where no animal manure has been fertilized during the past two years; and b) be accompanied by a certificate from a public veterinarian in the country of dispatch that the product has been harvested from farms where no restrictions have been set due to infectious animal disease. In addition, hay and straw from the United States and Canada must be accompanied by a certificate from a public veterinarian that the product has been harvested in states or provinces where Chronic Wasting Disease has not been detected on deer.

Attached files

http://faolex.fao.org/docs/pdf/nor189761.pdf

Web site

Forsiden - Lovdata

Offisiell kunngjøring av endringer i norske lover og forskrifter. Gratis tilgang til gjeldende lover og forskrifter, traktater og nye dommer.

www.lovdata.no

Date of text

22 Oct 2018

Repealed

No

Source language

English

Legislation Amendment

No

Original title

Forskrift om tilleggskrav ved import av høy og halm til dyrefôr.

Amends

Regulation prohibiting the importation of animals and infectious objects. on 22 Oct 2018

https://leap.unep.org/countries/no/...9-2018-additional-requirements-import-hay-and

DEFRA

Friday, December 14, 2012

DEFRA U.K. What is the risk of Chronic Wasting Disease CWD being introduced into Great Britain? A Qualitative Risk Assessment October 2012

snip.....

In summary, in endemic areas, there is a medium probability that the soil and surrounding environment is contaminated with CWD prions and in a bioavailable form. In rural areas where CWD has not been reported and deer are present, there is a greater than negligible risk the soil is contaminated with CWD prion. snip..... In summary, given the volume of tourists, hunters and servicemen moving between GB and North America, the probability of at least one person travelling to/from a CWD affected area and, in doing so, contaminating their clothing, footwear and/or equipment prior to arriving in GB is greater than negligible... For deer hunters, specifically, the risk is likely to be greater given the increased contact with deer and their environment. However, there is significant uncertainty associated with these estimates.

snip.....

Therefore, it is considered that farmed and park deer may have a higher probability of exposure to CWD transferred to the environment than wild deer given the restricted habitat range and higher frequency of contact with tourists and returning GB residents.
snip.....

https://web.archive.org/web/2017040.../files/qra_chronic-wasting-disease-121029.pdf

Carrot plants as potential vectors for CWD transmission

Paulina Sotoa,b, Francisca Bravo-Risia,b, Claudio Sotoa, and Rodrigo Moralesa,b

aDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Texas, USA; bUniversidad Bernardo O'Higgins, Santiago, Chile

Prion diseases are infectious neurodegenerative disorders afflicting humans and other mammals. These diseases are generated by the misfolding of the cellular prion protein into a disease-causing isoform. Chronic wasting disease (CWD) is a prevalent prion disease affecting cervids (captive and free-range). CWD is thought to be transmitted through direct animal contact or by indirect exposure to contaminated environments. Many studies have shown that infectious prions can enter the environment through saliva, feces, or urine from infected animals and decaying carcasses. However, we do not fully understand the specific contribution of each component to disease transmission events. Plants are logical environmental components to be evaluated since they grow in environments contaminated with CWD prions and are relevant for animal and human nutrition.

Aims: The main objective of this study is to study whether prions are transported to the roots and leaves of carrots, an edible plant commonly used in the human diet and as deer bait.

Methods: We have grown carrot plants in CWD-infected soils. After 90 days, we harvested the carrots and separated them from the leaves. The experiment was controlled by growing plants in soil samples treated with brain extracts from healthy animals. These materials were interrogated for their prion seeding activity using the Protein Misfolding Cyclic Amplification (PMCA) technique. Infectivity was evaluated in mouse bioassays (intracerebral injections in Tg1536 mice). The animals were sacrificed when they showed established signs of prion disease. Animals not displaying clinical signs were sacrificed at 600 days post-inoculation.

Results: The PMCA analysis demonstrated CWD seeding activity in soils contaminated with CWD prions, as well as in carrot plants (leaves and roots) grown on them. Bioassays demonstrated that both leaves and roots contained CWD prions in sufficient quantities to induce disease (92% attack rate). As expected, animals treated with prion-infected soils developed prion disease at shorter incubation periods (and complete attack rates) compared to plant components. Animals treated with soil and plant components exposed with CWD-free brain extracts did not display prion-associated clinical signs or evidence of sub-clinical prion infection.

Conclusions: We show that edible plant components can absorb prions from CWD contaminated soils and transport them to their aerial parts. Our results indicate that plants could participate as vectors of CWD transmission. Importantly, plants designated for human consumption represent a risk of introducing CWD prions into the human food chain.

Funded by: NIH

Grant number: R01AI132695

https://www.tandfonline.com/doi/full/10.1080/19336896.2022.2091286

 

[flounder]

First off, you're responding to a troll. Second, those deer are anything but tame. Many are far more scared of humans than most unfenced deer. Not all mind you, but they sure aren't tame. Third, CWD has been known about in wild animals for 50+ years. To say it's been overblown is an understatement to say the least.

"Currently, there is scientific evidence to suggest that CWD has zoonotic potential; however, no confirmed cases of CWD have been found in humans."

PART 2. TPWD CHAPTER 65. DIVISION 1. CWD

31 TAC §§65.82, 65.85, 65.88

The Texas Parks and Wildlife Commission in a duly noticed meeting on May 25, 2023 adopted amendments to 31 TAC §§65.82, 65.85, and §65.88, concerning Disease Detection and Response, without changes to the proposed text as published in the April 21, 2023, issue of the Texas Register (48 TexReg 2048). The rules will not be republished.

Currently, there is scientific evidence to suggest that CWD has zoonotic potential; however, no confirmed cases of CWD have been found in humans.

https://www.sos.texas.gov/texreg/ar...31.NATURAL RESOURCES AND CONSERVATION.html#57

17 DETECTION OF CHRONIC WASTING DISEASE PRIONS IN PROCESSED MEATS.

Rebeca Benavente1, Francisca Bravo1,2, Paulina Soto1,2, J. Hunter Reed3, Mitch Lockwood3, Rodrigo Morales1,2

1Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, USA. 2Universidad Bernardo O'Higgins, Santiago, Chile. 3Texas Parks and Wildlife, Austin, USA

Abstract

The zoonotic potential of chronic wasting disease (CWD) remains unknown. Currently, there are no known natural cases of CWD transmission to humans but increasing evidence suggests that the host range of CWD is not confined only to cervid species. Alarmingly, recent experimental evidence suggests that certain CWD isolates can induce disease in non-human primates. While the CDC strongly recommends determining CWD status in animals prior to consumption, this practice is voluntary. Consequently, it is plausible that a proportion of the cervid meat entering the human food chain may be contaminated with CWD. Of additional concern is that traditional diagnostic techniques used to detect CWD have relatively low sensitivity and are only approved for use in tissues other than those typically ingested by humans. In this study, we analyzed different processed meats derived from a pre-clinical, CWD-positive free-ranging elk. Products tested included filets, sausages, boneless steaks, burgers, ham steaks, seasoned chili meats, and spiced meats. CWD-prion presence in these products were assessed by PMCA using deer and elk substrates. Our results show positive prion detection in all products. To confirm the resilience of CWD-prions to traditional cooking methods, we grilled and boiled the meat products and evaluated them for any remnant PMCA seeding activity. Results confirmed the presence of CWD-prions in these meat products suggesting that infectious particles may still be available to people even after cooking. Our results strongly suggest ongoing human exposure to CWD-prions and raise significant concerns of zoonotic transmission through ingestion of CWD contaminated meat products.

***> Products tested included filets, sausages, boneless steaks, burgers, ham steaks, seasoned chili meats, and spiced meats.

***> CWD-prion presence in these products were assessed by PMCA using deer and elk substrates.

***> Our results show positive prion detection in all products.

***> Results confirmed the presence of CWD-prions in these meat products suggesting that infectious particles may still be available to people even after cooking.

***> Our results strongly suggest ongoing human exposure to CWD-prions and raise significant concerns of zoonotic transmission through ingestion of CWD contaminated meat products.

=====

Efficient CWD-like transmission of splenic prions in cervidized transgenic mice: a probable diagnostic marker for CWD infection in humans

Xu Qi, Liuting Qing, Manuel Camacho, Ignazio Cali, Qingzhong Kong

Department of Pathology, Case Western Reserve University, Cleveland, USA

***> Such experimentally generated splenic "humanized" CWD prions (termed eHuCWDsp) appear indistinguishable from prions in the brain of sCJDMM1 patients on Western blot.

Transmission of prion infectivity from CWD-infected macaque tissues to rodent models demonstrates the zoonotic potential of chronic wasting disease.

Samia Hannaoui1,2, Ginny Cheng1,2, Wiebke Wemheuer3, Walter Schulz-Schaeffer3, Sabine Gilch1,2, Hermann Schatzl1,2 1University of Calgary, Calgary, Canada. 2Calgary Prion Research Unit, Calgary, Canada. 3Institute of Neuropathology, Medical Faculty, Saarland University, Homburg/Saar, Germany

***> Further passage to cervidized mice revealed transmission with a 100% attack rate.

***> Our findings demonstrate that macaques, considered the best model for the zoonotic potential of prions, were infected upon CWD challenge, including the oral one.

****> The disease manifested as atypical in macaques and initial transgenic mouse transmissions, but with infectivity present at all times, as unveiled in the bank vole model with an unusual tissue tropism.

***> Epidemiologic surveillance of prion disease among cervid hunters and people likely to have consumed venison contaminated with chronic wasting disease

=====END

https://intcwdsympo.files.wordpress.com/2023/06/final-agenda-with-abstracts.pdf?force_download=true

Transmission

10:00 - 11:40am Thursday, 1st June, 2023

Plaza Ballroom

Moderator Dr. Tracy Nichols

10:00 - 10:20am

Transmission of prion infectivity from CWD-infected macaque tissues to rodent models demonstrates the zoonotic potential of chronic wasting disease.

Samia Hannaoui1,2, Ginny Cheng1,2, Wiebke Wemheuer3, Walter Schulz-Schaeffer3, Sabine Gilch1,2, Hermann Schatzl1,2 1University of Calgary, Calgary, Canada. 2Calgary Prion Research Unit, Calgary, Canada. 3Institute of Neuropathology, Medical Faculty, Saarland University, Homburg/Saar, Germany

Abstract

We provide evidence by transmission experiments to different transgenic mouse models and bank voles that Cynomolgus macaques inoculated via different routes with CWD-positive cervid tissues harbor infectious prions. We used tissue materials from macaques inoculated with CWD to inoculate transgenic mice overexpressing cervid PrPC followed by transmission into bank voles. We used RTQuIC, immunoblot and PET blot analysis to assess brains, spinal cords, and tissues of the gastrointestinal tract (GIT) for the presence of prions. Our results show that macaque materials induced clinical disease in transgenic mice with low attack rates. Clinical mice did not display PrPSc in immunoblot, but showed low-levels of prion seeding activity. Further transmission into bank voles led to a 100% attack rate with typical PrPSc signature in immunoblot, and high-level prion seeding activity in brain, spinal cord and GIT tissues. Second passage studies led to 100% attack rate in voles inoculated with brain, spinal cord and small intestine material from first round animals, with shortened survival times indicating adaptation in the new host.

This shows that prions detected in GIT tissues are infectious and transmissible.

Further passage to cervidized mice revealed transmission with a 100% attack rate.

Our findings demonstrate that macaques, considered the best model for the zoonotic potential of prions, were infected upon CWD challenge, including the oral one.

The disease manifested as atypical in macaques and initial transgenic mouse transmissions, but with infectivity present at all times, as unveiled in the bank vole model with an unusual tissue tropism.

***> Our findings demonstrate that macaques, considered the best model for the zoonotic potential of prions, were infected upon CWD challenge, including the oral one.

https://intcwdsympo.files.wordpress.com/2023/06/final-agenda-with-abstracts.pdf?force_download=true

terry

 

[flounder]

First off, you're responding to a troll. Second, those deer are anything but tame. Many are far more scared of humans than most unfenced deer. Not all mind you, but they sure aren't tame. Third, CWD has been known about in wild animals for 50+ years. To say it's been overblown is an understatement to say the least.

Subject: Re: DEER SPONGIFORM ENCEPHALOPATHY SURVEY & HOUND STUDY

Date: Fri, 18 Oct 2002 23:12:22 +0100

From: Steve Dealler

Reply-To: Bovine Spongiform Encephalopathy Organization: Netscape Online member

To: BSE-L@ References:

Dear Terry,

An excellent piece of review as this literature is desperately difficult to get back from Government sites.

What happened with the deer was that an association between deer meat eating and sporadic CJD was found in about 1993. The evidence was not great but did not disappear after several years of asking CJD cases what they had eaten. I think that the work into deer disease largely stopped because it was not helpful to the UK industry...and no specific cases were reported. Well, if you dont look adequately like they are in USA currenly then you wont find any!

Steve Dealler ===============

https://caninespongiformencephalopa.../03/canine-spongiform-encephalopathy-aka.html

''The association between venison eating and risk of CJD shows similar pattern, with regular venison eating associated with a 9 FOLD INCREASE IN RISK OF CJD (p = 0.04).''

CREUTZFELDT JAKOB DISEASE SURVEILLANCE IN THE UNITED KINGDOM THIRD ANNUAL REPORT AUGUST 1994

Consumption of venison and veal was much less widespread among both cases and controls. For both of these meats there was evidence of a trend with increasing frequency of consumption being associated with increasing risk of CJD. (not nvCJD, but sporadic CJD...tss) These associations were largely unchanged when attention was restricted to pairs with data obtained from relatives. ...

Table 9 presents the results of an analysis of these data.

There is STRONG evidence of an association between ''regular'' veal eating and risk of CJD (p = .0.01).

Individuals reported to eat veal on average at least once a year appear to be at 13 TIMES THE RISK of individuals who have never eaten veal.

There is, however, a very wide confidence interval around this estimate. There is no strong evidence that eating veal less than once per year is associated with increased risk of CJD (p = 0.51).

The association between venison eating and risk of CJD shows similar pattern, with regular venison eating associated with a 9 FOLD INCREASE IN RISK OF CJD (p = 0.04).

There is some evidence that risk of CJD INCREASES WITH INCREASING FREQUENCY OF LAMB EATING (p = 0.02).

The evidence for such an association between beef eating and CJD is weaker (p = 0.14). When only controls for whom a relative was interviewed are included, this evidence becomes a little STRONGER (p = 0.08).

snip...

It was found that when veal was included in the model with another exposure, the association between veal and CJD remained statistically significant (p = < 0.05 for all exposures), while the other exposures ceased to be statistically significant (p = > 0.05).

snip...

In conclusion, an analysis of dietary histories revealed statistical associations between various meats/animal products and INCREASED RISK OF CJD. When some account was taken of possible confounding, the association between VEAL EATING AND RISK OF CJD EMERGED AS THE STRONGEST OF THESE ASSOCIATIONS STATISTICALLY. ...

snip...

In the study in the USA, a range of foodstuffs were associated with an increased risk of CJD, including liver consumption which was associated with an apparent SIX-FOLD INCREASE IN THE RISK OF CJD. By comparing the data from 3 studies in relation to this particular dietary factor, the risk of liver consumption became non-significant with an odds ratio of 1.2 (PERSONAL COMMUNICATION, PROFESSOR A. HOFMAN. ERASMUS UNIVERSITY, ROTTERDAM). (???...TSS)

snip...see full report ;

http://web.archive.org/web/20090506050043/http://www.bseinquiry.gov.uk/files/yb/1994/08/00004001.pdf

http://web.archive.org/web/20090506050007/http://www.bseinquiry.gov.uk/files/yb/1994/10/00003001.pdf

http://web.archive.org/web/20090506050244/http://www.bseinquiry.gov.uk/files/yb/1994/07/00001001.pdf

 

[TexasJerseyMilker]

Now I see how he got to 1026 posts.

 

[Ebenezer]

But, again, how does that help control the disease?

 

[flounder]

But, again, how does that help control the disease?

i'm not sure cwd can be controlled...but here's my 2 cents;

Control of Chronic Wasting Disease OMB Control Number: 0579-0189 APHIS-2021-0004 Singeltary Submission

Greetings APHIS et al, i would kindly like to comment on Control of Chronic Wasting Disease OMB Control Number: 0579-0189 APHIS-2021-0004.

Greetings APHIS et al, i would kindly like to comment on Control of Chronic Wasting Disease OMB Control Number: 0579-0189 APHIS-2021-0004.

***> 1st and foremost your biggest problem is 'VOLUNTARY'! AS with the BSE 589.2001 FEED REGULATIONS, especially since it is still voluntary with cervid, knowing full well that cwd and scrapie will transmit to pigs by oral route. VOLUNTARY DOES NOT WORK! all animal products should be banned and be made mandatory, and the herd certification program should be mandatory, or you don't move cervid. IF THE CWD HERD CERTIFICATION IS NOT MANDATORY, it will be another colossal tse prion failure from the start.

***> 2nd USA should declare a Declaration of Extraordinary Emergency due to CWD, and all exports of cervid and cervid products must be stopped internationally, and there should be a ban of interstate movement of cervid, until a live cwd test is available.

***> 3rd Captive Farmed cervid ESCAPEES should be made mandatory to report immediately, and strict regulations for those suspect cwd deer that just happen to disappear. IF a cervid escapes and is not found, that farm should be indefinitely shut down, all movement, until aid MIA cervid is found, and if not ever found, that farm shut down permanently.

***> 4th Captive Farmed Cervid, INDEMNITY, NO MORE Federal indemnity program, or what i call, ENTITLEMENT PROGRAM for game farm industry. NO MORE BAIL OUTS FROM TAX PAYERS. if the captive industry can't buy insurance to protect not only themselves, but also their customers, and especially the STATE, from Chronic Wasting Disease CWD TSE Prion or what some call mad deer disease and harm therefrom, IF they can't afford to buy that insurance that will cover all of it, then they DO NOT GET A PERMIT to have a game farm for anything. This CWD TSE Prion can/could/has caused property values to fall from some reports in some places. roll the dice, how much is a state willing to lose?

***> 5th QUARANTINE OF ALL FARMED CAPTIVE, BREEDERS, URINE, ANTLER, VELVET, SPERM, OR ANY FACILITY, AND THEIR PRODUCTS, that has been confirmed to have Chronic Wasting Disease CWD TSE Prion, the QUARANTINE should be for 21 years due to science showing what scrapie can do. 5 years is NOT near long enough. see; Infectious agent of sheep scrapie may persist in the environment for at least 16 to 21 years.

***> 6th America BSE 589.2001 FEED REGULATIONS CWD TSE Prion

***> 7TH TRUCKING TRANSPORTING CERVID CHRONIC WASTING DISEASE TSE PRION VIOLATING THE LACEY ACT

***> 8TH ALL CAPTIVE FARMING CERVID OPERATIONS MUST BE INSURED TO PAY FOR ANY CLEAN UP OF CWD AND QUARANTINE THERE FROM FOR THE STATE, NO MORE ENTITLEMENT PROGRAM FOR CERVID GAME FARMING PAY TO PLAY FOR CWD TSE PRION OFF THE TAX PAYERS BACK.

***> 9TH ANY STATE WITH DOCUMENTED CWD, INTERSTATE, NATIONAL, AND INTERNATIONAL MOVEMENT OF ALL CERVID, AND ALL CERVID PRODUCTS MUST BE HALTED!

***> 10TH BAN THE SALE OF STRAW BRED BUCKS AND ALL CERVID SEMEN AND URINE PRODUCTS

***> 11th ALL CAPTIVE FARMED CERVID AND THEIR PRODUCTS MUST BE CWD TSE PRION TESTED ANNUALLY AND BEFORE SALE FOR CWD TSE PRION

SEE FULL SCIENCE REFERENCES AND REASONINGS ;

***> 1st and foremost your biggest problem is 'VOLUNTARY'!

''APHIS created a cooperative, voluntary Federal-State-private sector CWD Herd Certification Program designed to identify farmed or captive herds infected with CWD.''

key word failure is 'voluntary'.

WE know for a fact now that voluntary does NOT WORK!

AS with the BSE 589.2001 FEED REGULATIONS (see , another colossal failure, and proven to be a sham, especially since it is still voluntary with cervid, knowing full well that cwd and scrapie will transmit to pigs by oral route. VOLUNTARY DOES NOT WORK! all animal products should be banned and be made mandatory, and the herd certification program should be mandatory, or you don't move cervid. IF THE CWD HERD CERTIFICATION IS NOT MANDATORY, it will be another colossal tse prion failure from the start.

***> 2nd USA should declare a Declaration of Extraordinary Emergency due to CWD, and all exports of cervid and cervid products must be stopped internationally, and there should be a ban of interstate movement of cervid, until a live cwd test is available.

***> 3rd Captive Farmed cervid ESCAPEES should be made mandatory to report immediately, and strict regulations for those suspect cwd deer that just happen to disappear. IF a cervid escapes and is not found, that farm should be indefinitely shut down, all movement, until aid MIA cervid is found, and if not ever found, that farm shut down permanently. ...snip...see full text submission with science references...TSS

Control of Chronic Wasting Disease OMB Control Number: 0579-0189 APHIS-2021-0004 Singeltary Submission

https://www.regulations.gov/comment/APHIS-2021-0004-0002

https://downloads.regulations.gov/APHIS-2021-0004-0002/attachment_1.pdf

Docket No. APHIS-2018-0011 Chronic Wasting Disease Herd Certification

https://www.regulations.gov/document/APHIS-2018-0011-0003

https://downloads.regulations.gov/APHIS-2018-0011-0003/attachment_1.pdf

MONDAY, MAY 15, 2023

TAHC Chapter 40, Chronic Wasting Disease and Scrapie Chapter 60, Singeltary Comment Submission

Greetings TAHC et al,

Thank you kindly for giving me the opportunity to once again comment on CWD and Scrapie.

I want to thank the TAHC and the TPWD for coming together and seems now bring forth sound science, of the real risk factors for both CWD and Scrapie.

With great urgency, i wish to bring your attention on updated Science on Chronic Wasting Disease CWD and Scrapie TSE Prion Environmental Factors and Zoonotic factors, spillover risk factors of CWD and Scrapie to other species i.e. PIGS, our failed feed ban of which now should include all cervid and pigs imo. i saw no mention of atypical Scrapie and the new science from EFSA, i shall include that as well. there is a new TSE Prion disease in a new livestock species the Camel, you should all be aware of. all of this is most important, and should be addressed in any cwd update imo, especially with CWD and Scrapie transmitting to pigs by oral routes.

i will post my concerns below, Thank You Kindly...terry

TAHC Chapter 40, Chronic Wasting Disease and Scrapie Chapter 60, Singeltary Comment Submission

 

[Caustic Burno]

This is all BS and will have no impact on the billionaires and millionaires hunting lobby in Austin!
They will instruct the TPWD commissioners on the regulations enacted.
The commissioners are appointed by the governor this is lobbying at its finest.

 

[TexasJerseyMilker]

In 2021, CWD was detected in two Idaho mule deer within 30 miles of the Oregon border.

Oregon dept of fish and wildlife is all over this.

• CWD check stations during hunting seasons will help ODFW monitor the potential spread of the disease in Oregon.
• If you harvest a deer or elk and encounter a CWD check station on your way home, you MUST STOP and have your animal tested. It's the law.
• When hunting out of state, don't bring home to Oregon the brain and spinal column of animals your harvested. These are the body parts known to harbor the disease.

Oregon Department of Fish & Wildlife

myodfw.com

 

[greybeard]

This is all caused by underbite which is being systematically covered up as CWD and BSE cases.

 

[moses388]

When I rake hay and see deer poop stuck to the tractor tire, CWD is something I think about.

 

[Nesikep]

***> 2nd USA should declare a Declaration of Extraordinary Emergency due to CWD, and all exports of cervid and cervid products must be stopped internationally, and there should be a ban of interstate movement of cervid, until a live cwd test is available.

How'd that work for covid?

 

[TexasJerseyMilker]

If it transmits to pigs by oral route, maybe it is already in the dadgummed feral hogs.

 

[TexasJerseyMilker]

Texas Effort To Kill 500 Deer Hits A Major Snag

"I may be broke before it's over, but I don't want to kill my deer."

www.huffpost.com