Brazil MAPA OMSA Confirms BSE TSE Prion atypical H-type
(Google Translated...tss)
OFFICIAL NOTE - Map confirms that case of Bovine Spongiform Encephalopathy is atypical type H
Ministry is immediately adopting measures so that exports of Brazilian beef are reestablished as soon as possible
Published on 03/02/2023 22:18 Updated on 03/03/2023 00:08
According to the indications of the technical staff of the Ministry of Agriculture and Livestock (MAPA), the analysis of the reference laboratory of the World Organization for Animal Health (OMSA) confirmed, on Thursday night (02), that the isolated case of Spongiform Encephalopathy Bovine (BEE) detected in the municipality of Marabá (PA) is atypical type H.
The Minister of Agriculture and Livestock, Carlos Fávaro, immediately communicated the result of the sample to President Luiz Inácio Lula da Silva and immediately began inserting said information into the system for official communication to the WHOA and the Chinese authorities.
Once the process is completed, a virtual meeting will be scheduled with the Chinese government to deal with the release of beef exports to the country.
"I emphasize that speed, efficiency and the transparency requested by President Lula was fundamental. I thank our team and that of the governor of Pará, Helder Barbalho, who allowed us to act quickly from the identification of the case", commented Fávaro.
As this is an atypical case, that is, it occurred due to natural causes in a single 9-year-old animal and with all health measures promptly adopted, the Ministry of Agriculture and Livestock is immediately adopting measures, in accordance with health protocols , so that Brazilian beef exports are reestablished as soon as possible.
Press Releases [email protected]
https://www.gov.br/agricultura/pt-b...e-encefalopatia-espongiforme-bovina-e-atipico
Brazil Confirms BSE Mad Cow Case, Strain not known yet
OFFICIAL NOTE
Mapa adopts measures on BSE case in Brazil
Meat for market consumption is not affected by confirmation
Published on 02/22/2023 8:15 pm Updated on 02/22/2023 9:51 pm
https://www.gov.br/agricultura/pt-b...ta-providencias-sobre-caso-de-eeb-no-brasil-1
Brazil Suspected case of bovine spongiform encephalopathy
COMUNICADO
Caso suspeito de Encefalopatia Espongiforme Bovina
para Copiar para área de transferência Publicado em 20/02/2023 15h36
Atualizado em 20/02/2023 15h39 O
Suspected case of bovine spongiform encephalopathy
to Copy to clipboard Posted on 2/20/2023 3:36 PM
Updated on 02/20/2023 3:39 pm The
Ministry of Agriculture and Livestock (MAPA) informs that, regarding the suspected case of Bovine Spongiform Encephalopathy ("Mad Cow Disease"), all measures are being adopted by governments.
The suspicion has already been submitted to laboratory analysis for confirmation or not and, based on the result, the appropriate actions will be applied immediately.
https://www.gov.br/agricultura/pt-b...suspeito-de-encefalopatia-espongiforme-bovina
2023/01/18
EVENT 4918
Brazil - Bovine spongiform encephalopathy
https://wahis.woah.org/#/in-event/4918/dashboard
''H-TYPE BSE AGENT IS TRANSMISSIBLE BY THE ORONASAL ROUTE''
This study demonstrates that the H-type BSE agent is transmissible by the oronasal route. These results reinforce the need for ongoing surveillance for classical and atypical BSE to minimize the risk of potentially infectious tissues entering the animal or human food chains.
https://www.ars.usda.gov/research/publications/publication/?seqNo115=353094
OIE Conclusions on transmissibility of atypical BSE among cattle
Given that cattle have been successfully infected by the oral route, at least for L-BSE, it is reasonable to conclude that atypical BSE is potentially capable of being recycled in a cattle population if cattle are exposed to contaminated feed. In addition, based on reports of atypical BSE from several countries that have not had C-BSE, it appears likely that atypical BSE would arise as a spontaneous disease in any country, albeit at a very low incidence in old cattle. In the presence of livestock industry practices that would allow it to be recycled in the cattle feed chain, it is likely that some level of exposure and transmission may occur. As a result, since atypical BSE can be reasonably considered to pose a potential background level of risk for any country with cattle, the recycling of both classical and atypical strains in the cattle and broader ruminant populations should be avoided.
https://www.oie.int/fileadmin/SST/a...alopathy/AN/A_AhG_BSEsurv_RiskAss_Mar2019.pdf
Annex 7 (contd) AHG on BSE risk assessment and surveillance/March 2019
34 Scientific Commission/September 2019
3. Atypical BSE
The Group discussed and endorsed with minor revisions an overview of relevant literature on the risk of atypical BSE being recycled in a cattle population and its zoonotic potential that had been prepared ahead of the meeting by one expert from the Group. This overview is provided as Appendix IV and its main conclusions are outlined below. With regard to the risk of recycling of atypical BSE, recently published research confirmed that the L-type BSE prion (a type of atypical BSE prion) may be orally transmitted to calves1 . In light of this evidence, and the likelihood that atypical BSE could arise as a spontaneous disease in any country, albeit at a very low incidence, the Group was of the opinion that it would be reasonable to conclude that atypical BSE is potentially capable of being recycled in a cattle population if cattle were to be exposed to contaminated feed. Therefore, the recycling of atypical strains in cattle and broader ruminant populations should be avoided.
The Group acknowledged the challenges in demonstrating the zoonotic transmission of atypical strains of BSE in natural exposure scenarios. Overall, the Group was of the opinion that, at this stage, it would be premature to reach a conclusion other than that atypical BSE poses a potential zoonotic risk that may be different between atypical strains.
4. Definitions of meat-and-bone meal (MBM) and greaves
snip...
REFERENCES
SNIP...END SEE FULL TEXT;
http://web.oie.int/downld/PROC2020/A_SCAD_Sept2019.pdf
Consumption of L-BSE–contaminated feed may pose a risk for oral transmission of the disease agent to cattle.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324790/
Thus, it is imperative to maintain measures that prevent the entry of tissues from cattle possibly infected with the agent of L-BSE into the food chain.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310119/
We recently observed the direct transmission of a natural classical scrapie isolate to macaque after a 10-year silent incubation period, with features similar to some reported for human cases of sporadic CJD, albeit requiring fourfold longe incubation than BSE. Scrapie, as recently evoked in humanized mice (Cassard, 2014), is the third potentially zoonotic PD (with BSE and L-type BSE), thus questioning the origin of human sporadic cases. We will present an updated panorama of our different transmission studies and discuss the implications of such extended incubation periods on risk assessment of animal PD for human health.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019500/
2.3.2. New evidence on the zoonotic potential of atypical BSE and atypical scrapie prion strains
Olivier Andreoletti, INRA Research Director, Institut National de la Recherche Agronomique (INRA) – École Nationale Vétérinaire de Toulouse (ENVT), invited speaker, presented the results of two recently published scientific articles of interest, of which he is co-author:
'Radical Change in Zoonotic Abilities of Atypical BSE Prion Strains as Evidenced by Crossing of Sheep Species Barrier in Transgenic Mice' (MarinMoreno et al., 2020) and 'The emergence of classical BSE from atypical/Nor98 scrapie' (Huor et al., 2019).
In the first experimental study, H-type and L-type BSE were inoculated into transgenic mice expressing all three genotypes of the human PRNP at codon 129 and into adapted into ARQ and VRQ transgenic sheep mice. The results showed the alterations of the capacities to cross the human barrier species (mouse model) and emergence of sporadic CJD agents in Hu PrP expressing mice: type 2 sCJD in homozygous TgVal129 VRQ-passaged L-BSE, and type 1 sCJD in homozygous TgVal 129 and TgMet129 VRQ-passaged H-BSE.
https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/sp.efsa.2020.EN-1946
This study demonstrates that the H-type BSE agent is transmissible by the oronasal route. These results reinforce the need for ongoing surveillance for classical and atypical BSE to minimize the risk of potentially infectious tissues entering the animal or human food chains.
https://www.ars.usda.gov/research/publications/publication/?seqNo115=353094
***Moreover, sporadic disease has never been observed in breeding colonies or primate research laboratories, most notably among hundreds of animals over several decades of study at the National Institutes of Health25, and in nearly twenty older animals continuously housed in our own facility.***
Even if the prevailing view is that sporadic CJD is due to the spontaneous formation of CJD prions, it remains possible that its apparent sporadic nature may, at least in part, result from our limited capacity to identify an environmental origin.
https://www.nature.com/articles/srep11573
kind regards, terry
(Google Translated...tss)
OFFICIAL NOTE - Map confirms that case of Bovine Spongiform Encephalopathy is atypical type H
Ministry is immediately adopting measures so that exports of Brazilian beef are reestablished as soon as possible
Published on 03/02/2023 22:18 Updated on 03/03/2023 00:08
According to the indications of the technical staff of the Ministry of Agriculture and Livestock (MAPA), the analysis of the reference laboratory of the World Organization for Animal Health (OMSA) confirmed, on Thursday night (02), that the isolated case of Spongiform Encephalopathy Bovine (BEE) detected in the municipality of Marabá (PA) is atypical type H.
The Minister of Agriculture and Livestock, Carlos Fávaro, immediately communicated the result of the sample to President Luiz Inácio Lula da Silva and immediately began inserting said information into the system for official communication to the WHOA and the Chinese authorities.
Once the process is completed, a virtual meeting will be scheduled with the Chinese government to deal with the release of beef exports to the country.
"I emphasize that speed, efficiency and the transparency requested by President Lula was fundamental. I thank our team and that of the governor of Pará, Helder Barbalho, who allowed us to act quickly from the identification of the case", commented Fávaro.
As this is an atypical case, that is, it occurred due to natural causes in a single 9-year-old animal and with all health measures promptly adopted, the Ministry of Agriculture and Livestock is immediately adopting measures, in accordance with health protocols , so that Brazilian beef exports are reestablished as soon as possible.
Press Releases [email protected]
https://www.gov.br/agricultura/pt-b...e-encefalopatia-espongiforme-bovina-e-atipico
Brazil Confirms BSE Mad Cow Case, Strain not known yet
OFFICIAL NOTE
Mapa adopts measures on BSE case in Brazil
Meat for market consumption is not affected by confirmation
Published on 02/22/2023 8:15 pm Updated on 02/22/2023 9:51 pm
https://www.gov.br/agricultura/pt-b...ta-providencias-sobre-caso-de-eeb-no-brasil-1
Brazil Suspected case of bovine spongiform encephalopathy
COMUNICADO
Caso suspeito de Encefalopatia Espongiforme Bovina
para Copiar para área de transferência Publicado em 20/02/2023 15h36
Atualizado em 20/02/2023 15h39 O
Suspected case of bovine spongiform encephalopathy
to Copy to clipboard Posted on 2/20/2023 3:36 PM
Updated on 02/20/2023 3:39 pm The
Ministry of Agriculture and Livestock (MAPA) informs that, regarding the suspected case of Bovine Spongiform Encephalopathy ("Mad Cow Disease"), all measures are being adopted by governments.
The suspicion has already been submitted to laboratory analysis for confirmation or not and, based on the result, the appropriate actions will be applied immediately.
https://www.gov.br/agricultura/pt-b...suspeito-de-encefalopatia-espongiforme-bovina
2023/01/18
EVENT 4918
Brazil - Bovine spongiform encephalopathy
https://wahis.woah.org/#/in-event/4918/dashboard
''H-TYPE BSE AGENT IS TRANSMISSIBLE BY THE ORONASAL ROUTE''
This study demonstrates that the H-type BSE agent is transmissible by the oronasal route. These results reinforce the need for ongoing surveillance for classical and atypical BSE to minimize the risk of potentially infectious tissues entering the animal or human food chains.
https://www.ars.usda.gov/research/publications/publication/?seqNo115=353094
OIE Conclusions on transmissibility of atypical BSE among cattle
Given that cattle have been successfully infected by the oral route, at least for L-BSE, it is reasonable to conclude that atypical BSE is potentially capable of being recycled in a cattle population if cattle are exposed to contaminated feed. In addition, based on reports of atypical BSE from several countries that have not had C-BSE, it appears likely that atypical BSE would arise as a spontaneous disease in any country, albeit at a very low incidence in old cattle. In the presence of livestock industry practices that would allow it to be recycled in the cattle feed chain, it is likely that some level of exposure and transmission may occur. As a result, since atypical BSE can be reasonably considered to pose a potential background level of risk for any country with cattle, the recycling of both classical and atypical strains in the cattle and broader ruminant populations should be avoided.
https://www.oie.int/fileadmin/SST/a...alopathy/AN/A_AhG_BSEsurv_RiskAss_Mar2019.pdf
Annex 7 (contd) AHG on BSE risk assessment and surveillance/March 2019
34 Scientific Commission/September 2019
3. Atypical BSE
The Group discussed and endorsed with minor revisions an overview of relevant literature on the risk of atypical BSE being recycled in a cattle population and its zoonotic potential that had been prepared ahead of the meeting by one expert from the Group. This overview is provided as Appendix IV and its main conclusions are outlined below. With regard to the risk of recycling of atypical BSE, recently published research confirmed that the L-type BSE prion (a type of atypical BSE prion) may be orally transmitted to calves1 . In light of this evidence, and the likelihood that atypical BSE could arise as a spontaneous disease in any country, albeit at a very low incidence, the Group was of the opinion that it would be reasonable to conclude that atypical BSE is potentially capable of being recycled in a cattle population if cattle were to be exposed to contaminated feed. Therefore, the recycling of atypical strains in cattle and broader ruminant populations should be avoided.
The Group acknowledged the challenges in demonstrating the zoonotic transmission of atypical strains of BSE in natural exposure scenarios. Overall, the Group was of the opinion that, at this stage, it would be premature to reach a conclusion other than that atypical BSE poses a potential zoonotic risk that may be different between atypical strains.
4. Definitions of meat-and-bone meal (MBM) and greaves
snip...
REFERENCES
SNIP...END SEE FULL TEXT;
http://web.oie.int/downld/PROC2020/A_SCAD_Sept2019.pdf
Consumption of L-BSE–contaminated feed may pose a risk for oral transmission of the disease agent to cattle.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324790/
Thus, it is imperative to maintain measures that prevent the entry of tissues from cattle possibly infected with the agent of L-BSE into the food chain.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310119/
We recently observed the direct transmission of a natural classical scrapie isolate to macaque after a 10-year silent incubation period, with features similar to some reported for human cases of sporadic CJD, albeit requiring fourfold longe incubation than BSE. Scrapie, as recently evoked in humanized mice (Cassard, 2014), is the third potentially zoonotic PD (with BSE and L-type BSE), thus questioning the origin of human sporadic cases. We will present an updated panorama of our different transmission studies and discuss the implications of such extended incubation periods on risk assessment of animal PD for human health.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019500/
2.3.2. New evidence on the zoonotic potential of atypical BSE and atypical scrapie prion strains
Olivier Andreoletti, INRA Research Director, Institut National de la Recherche Agronomique (INRA) – École Nationale Vétérinaire de Toulouse (ENVT), invited speaker, presented the results of two recently published scientific articles of interest, of which he is co-author:
'Radical Change in Zoonotic Abilities of Atypical BSE Prion Strains as Evidenced by Crossing of Sheep Species Barrier in Transgenic Mice' (MarinMoreno et al., 2020) and 'The emergence of classical BSE from atypical/Nor98 scrapie' (Huor et al., 2019).
In the first experimental study, H-type and L-type BSE were inoculated into transgenic mice expressing all three genotypes of the human PRNP at codon 129 and into adapted into ARQ and VRQ transgenic sheep mice. The results showed the alterations of the capacities to cross the human barrier species (mouse model) and emergence of sporadic CJD agents in Hu PrP expressing mice: type 2 sCJD in homozygous TgVal129 VRQ-passaged L-BSE, and type 1 sCJD in homozygous TgVal 129 and TgMet129 VRQ-passaged H-BSE.
https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/sp.efsa.2020.EN-1946
This study demonstrates that the H-type BSE agent is transmissible by the oronasal route. These results reinforce the need for ongoing surveillance for classical and atypical BSE to minimize the risk of potentially infectious tissues entering the animal or human food chains.
https://www.ars.usda.gov/research/publications/publication/?seqNo115=353094
***Moreover, sporadic disease has never been observed in breeding colonies or primate research laboratories, most notably among hundreds of animals over several decades of study at the National Institutes of Health25, and in nearly twenty older animals continuously housed in our own facility.***
Even if the prevailing view is that sporadic CJD is due to the spontaneous formation of CJD prions, it remains possible that its apparent sporadic nature may, at least in part, result from our limited capacity to identify an environmental origin.
https://www.nature.com/articles/srep11573
kind regards, terry
