OIE WAHIS SPAIN BOVINE SPONGIFORM ENCEPHALOPATHY BSE Atypical H-Type
Spain - Bovine spongiform encephalopathy - Immediate notification
GENERAL INFORMATION
COUNTRY/TERRITORY OR ZONE
ZONE
ANIMAL TYPE
TERRESTRIAL
DISEASE CATEGORY
OIE-listed
EVENT ID
4888
DISEASE
Bovine spongiform encephalopathy
CAUSAL AGENT
Bovine spongiform encephalopathy prion, atypical strain, H-type
GENOTYPE / SEROTYPE / SUBTYPE
START DATE
2023/01/21
REASON FOR NOTIFICATION
Recurrence of an eradicated disease
DATE OF LAST OCCURRENCE
2021/04/16
CONFIRMATION DATE
2023/02/03
EVENT STATUS
Resolved
END DATE
2023/02/06
SELF-DECLARATION
NO
REPORT INFORMATION
REPORT NUMBER
Immediate notification
REPORT ID
IN_159183
REPORT REFERENCE
REPORT DATE
2023/02/07
REPORT STATUS
Validated
NO EVOLUTION REPORT
EPIDEMIOLOGY
SOURCE OF EVENT OR ORIGIN OF INFECTION
Unknown or inconclusive
EPIDEMIOLOGICAL COMMENTS
Point 1 of paragraph 2, Chapter B (Measures following confirmation of a TSE in cattle) of ANNEX VII - CONTROL AND ERADICATION OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES of Regulation (EC) 999/2001 establishes that in case of confirmation of BSE in a bovine animal, all cattle identified in the following cases must be killed and completely destroyed: - in cases where the disease has been confirmed in a female, all her offspring born within two years before or after the clinical onset of the disease, - all animals in the age group of the animal in which the disease has been confirmed, - other animals present on the holding of the animal in which the disease was confirmed, or on other holdings, which may have been infected by the TSE agent or exposed to the same feed or source of contamination. Based on investigations of the two cattle identified on the case farm, they are NOT: - descendants of the affected animal, - cattle that, during their first year of life, were raised with the case so that in their first year of life they have not consumed the same feed, - cattle born during the twelve months before or after the birth of the affected animal, - nor have had access to the same feed while on the farm. So that their slaughter is not considered necessary. However, and as required by European legislation, they were identified for epidemiological investigation as in all cases of BSE.
QUANTITATIVE DATA SUMMARY
MEASURING UNIT
Animal
Species Susceptible Cases Deaths Killed and Disposed of Slaughtered/ Killed for commercial use Vaccinated Cattle (DOMESTIC)NEW11-1--TOTAL11-1--
DIAGNOSTIC DETAILS
CLINICAL SIGNS
NO
METHOD OF DIAGNOSTIC
Diagnostic test
Test name Laboratory Species sampled Outbreaks Result date Result
Antigen detection Western blot (Ag Western blot) Laboratorio Central de Veterinaria de Algete Cattle Pontevedra 2023/02/03 Positive
Immunohistochemistry (IHC) Laboratorio Central de Veterinaria de Algete Cattle Pontevedra 2023/02/03 Positive
CONTROL MEASURES AT EVENT LEVEL
CONTROL MEASURES AT EVENT LEVEL
DOMESTIC ANIMALS
WILD ANIMALS
Traceability
Applied
Official disposal of carcasses, by-products and waste
Applied
https://wahis.woah.org/#/in-review/4888
Conclusions on transmissibility of atypical BSE among cattle
Given that cattle have been successfully infected by the oral route, at least for L-BSE, it is reasonable to conclude that atypical BSE is potentially capable of being recycled in a cattle population if cattle are exposed to contaminated feed. In addition, based on reports of atypical BSE from several countries that have not had C-BSE, it appears likely that atypical BSE would arise as a spontaneous disease in any country, albeit at a very low incidence in old cattle. In the presence of livestock industry practices that would allow it to be recycled in the cattle feed chain, it is likely that some level of exposure and transmission may occur. As a result, since atypical BSE can be reasonably considered to pose a potential background level of risk for any country with cattle, the recycling of both classical and atypical strains in the cattle and broader ruminant populations should be avoided.
see full report;
REPORT OF THE MEETING OF THE OIE AD HOC GROUP ON BOVINE SPONGIFORM ENCEPHALOPATHY RISK ASSESSMENT AND SURVEILLANCE
Paris, 18-21 March 2019
snip...
https://www.oie.int/fileadmin/SST/adhocreports/Bovine spongiform encephalopathy/AN/A_AhG_BSEsurv_RiskAss_Mar2019.pdf
***> Consumption of L-BSE–contaminated feed may pose a risk for oral transmission of the disease agent to cattle.
***> As a result, since atypical BSE can be reasonably considered to pose a potential background level of risk for any country with cattle, the recycling of both classical and atypical strains in the cattle and broader ruminant populations should be avoided.
***> This study demonstrates that the H-type BSE agent is transmissible by the oronasal route.
***> These results reinforce the need for ongoing surveillance for classical and atypical BSE to minimize the risk of potentially infectious tissues entering the animal or human food chains.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324790/
Our study clearly confirms, experimentally, the potential risk for interspecies oral transmission of the agent of L-BSE. In our model, this risk appears higher than that for the agent of classical BSE, which could only be transmitted to mouse lemurs after a first passage in macaques (14). We report oral transmission of the L-BSE agent in young and adult primates. Transmission by the IC route has also been reported in young macaques (6,7). A previous study of L-BSE in transgenic mice expressing human PrP suggested an absence of any transmission barrier between cattle and humans for this particular strain of the agent of BSE, in contrast to findings for the agent of classical BSE (9). Thus, it is imperative to maintain measures that prevent the entry of tissues from cattle possibly infected with the agent of L-BSE into the food chain.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310119/
Atypical H-type BSE
Research Project: Pathobiology, Genetics, and Detection of Transmissible Spongiform Encephalopathies Location: Virus and Prion Research
Title: The agent of H-type bovine spongiform encephalopathy associated with E211K prion protein polymorphism transmits after oronasal challenge
Author item Greenlee, Justin item MOORE, S - Orise Fellow item WEST-GREENLEE, M - Iowa State University
This study demonstrates that the H-type BSE agent is transmissible by the oronasal route.
These results reinforce the need for ongoing surveillance for classical and atypical BSE to minimize the risk of potentially infectious tissues entering the animal or human food chains.
https://www.ars.usda.gov/research/publications/publication/?seqNo115=353094
Friday, February 10, 2023
OIE WAHIS SPAIN BOVINE SPONGIFORM ENCEPHALOPATHY BSE Atypical H-Type
https://woahoie.blogspot.com/2023/02/oie-wahis-spain-bovine-spongiform.html
terry
Spain - Bovine spongiform encephalopathy - Immediate notification
GENERAL INFORMATION
COUNTRY/TERRITORY OR ZONE
ZONE
ANIMAL TYPE
TERRESTRIAL
DISEASE CATEGORY
OIE-listed
EVENT ID
4888
DISEASE
Bovine spongiform encephalopathy
CAUSAL AGENT
Bovine spongiform encephalopathy prion, atypical strain, H-type
GENOTYPE / SEROTYPE / SUBTYPE
START DATE
2023/01/21
REASON FOR NOTIFICATION
Recurrence of an eradicated disease
DATE OF LAST OCCURRENCE
2021/04/16
CONFIRMATION DATE
2023/02/03
EVENT STATUS
Resolved
END DATE
2023/02/06
SELF-DECLARATION
NO
REPORT INFORMATION
REPORT NUMBER
Immediate notification
REPORT ID
IN_159183
REPORT REFERENCE
REPORT DATE
2023/02/07
REPORT STATUS
Validated
NO EVOLUTION REPORT
EPIDEMIOLOGY
SOURCE OF EVENT OR ORIGIN OF INFECTION
Unknown or inconclusive
EPIDEMIOLOGICAL COMMENTS
Point 1 of paragraph 2, Chapter B (Measures following confirmation of a TSE in cattle) of ANNEX VII - CONTROL AND ERADICATION OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES of Regulation (EC) 999/2001 establishes that in case of confirmation of BSE in a bovine animal, all cattle identified in the following cases must be killed and completely destroyed: - in cases where the disease has been confirmed in a female, all her offspring born within two years before or after the clinical onset of the disease, - all animals in the age group of the animal in which the disease has been confirmed, - other animals present on the holding of the animal in which the disease was confirmed, or on other holdings, which may have been infected by the TSE agent or exposed to the same feed or source of contamination. Based on investigations of the two cattle identified on the case farm, they are NOT: - descendants of the affected animal, - cattle that, during their first year of life, were raised with the case so that in their first year of life they have not consumed the same feed, - cattle born during the twelve months before or after the birth of the affected animal, - nor have had access to the same feed while on the farm. So that their slaughter is not considered necessary. However, and as required by European legislation, they were identified for epidemiological investigation as in all cases of BSE.
QUANTITATIVE DATA SUMMARY
MEASURING UNIT
Animal
Species Susceptible Cases Deaths Killed and Disposed of Slaughtered/ Killed for commercial use Vaccinated Cattle (DOMESTIC)NEW11-1--TOTAL11-1--
DIAGNOSTIC DETAILS
CLINICAL SIGNS
NO
METHOD OF DIAGNOSTIC
Diagnostic test
Test name Laboratory Species sampled Outbreaks Result date Result
Antigen detection Western blot (Ag Western blot) Laboratorio Central de Veterinaria de Algete Cattle Pontevedra 2023/02/03 Positive
Immunohistochemistry (IHC) Laboratorio Central de Veterinaria de Algete Cattle Pontevedra 2023/02/03 Positive
CONTROL MEASURES AT EVENT LEVEL
CONTROL MEASURES AT EVENT LEVEL
DOMESTIC ANIMALS
WILD ANIMALS
Traceability
Applied
Official disposal of carcasses, by-products and waste
Applied
https://wahis.woah.org/#/in-review/4888
Conclusions on transmissibility of atypical BSE among cattle
Given that cattle have been successfully infected by the oral route, at least for L-BSE, it is reasonable to conclude that atypical BSE is potentially capable of being recycled in a cattle population if cattle are exposed to contaminated feed. In addition, based on reports of atypical BSE from several countries that have not had C-BSE, it appears likely that atypical BSE would arise as a spontaneous disease in any country, albeit at a very low incidence in old cattle. In the presence of livestock industry practices that would allow it to be recycled in the cattle feed chain, it is likely that some level of exposure and transmission may occur. As a result, since atypical BSE can be reasonably considered to pose a potential background level of risk for any country with cattle, the recycling of both classical and atypical strains in the cattle and broader ruminant populations should be avoided.
see full report;
REPORT OF THE MEETING OF THE OIE AD HOC GROUP ON BOVINE SPONGIFORM ENCEPHALOPATHY RISK ASSESSMENT AND SURVEILLANCE
Paris, 18-21 March 2019
snip...
https://www.oie.int/fileadmin/SST/adhocreports/Bovine spongiform encephalopathy/AN/A_AhG_BSEsurv_RiskAss_Mar2019.pdf
***> Consumption of L-BSE–contaminated feed may pose a risk for oral transmission of the disease agent to cattle.
***> As a result, since atypical BSE can be reasonably considered to pose a potential background level of risk for any country with cattle, the recycling of both classical and atypical strains in the cattle and broader ruminant populations should be avoided.
***> This study demonstrates that the H-type BSE agent is transmissible by the oronasal route.
***> These results reinforce the need for ongoing surveillance for classical and atypical BSE to minimize the risk of potentially infectious tissues entering the animal or human food chains.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324790/
Our study clearly confirms, experimentally, the potential risk for interspecies oral transmission of the agent of L-BSE. In our model, this risk appears higher than that for the agent of classical BSE, which could only be transmitted to mouse lemurs after a first passage in macaques (14). We report oral transmission of the L-BSE agent in young and adult primates. Transmission by the IC route has also been reported in young macaques (6,7). A previous study of L-BSE in transgenic mice expressing human PrP suggested an absence of any transmission barrier between cattle and humans for this particular strain of the agent of BSE, in contrast to findings for the agent of classical BSE (9). Thus, it is imperative to maintain measures that prevent the entry of tissues from cattle possibly infected with the agent of L-BSE into the food chain.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310119/
Atypical H-type BSE
Research Project: Pathobiology, Genetics, and Detection of Transmissible Spongiform Encephalopathies Location: Virus and Prion Research
Title: The agent of H-type bovine spongiform encephalopathy associated with E211K prion protein polymorphism transmits after oronasal challenge
Author item Greenlee, Justin item MOORE, S - Orise Fellow item WEST-GREENLEE, M - Iowa State University
This study demonstrates that the H-type BSE agent is transmissible by the oronasal route.
These results reinforce the need for ongoing surveillance for classical and atypical BSE to minimize the risk of potentially infectious tissues entering the animal or human food chains.
https://www.ars.usda.gov/research/publications/publication/?seqNo115=353094
Friday, February 10, 2023
OIE WAHIS SPAIN BOVINE SPONGIFORM ENCEPHALOPATHY BSE Atypical H-Type
https://woahoie.blogspot.com/2023/02/oie-wahis-spain-bovine-spongiform.html
terry
