I think it could be a good idea depending on your location. If your near lots of smaller operations that you could travel easily between especially if you have more than one set of clients go out of town at once I could see it working well. Where we live the distance between places I would think would be to big and it would not be worth your time unless you charged a lot.
Regarding "what's a vacation" well I'm forced to go on 2 a year. Back 15 years ago when the preacher was talking with the wife and I before we got married he told me I needed to change my ways if our marriage was going to work. I do the 2 a year trips and she stays happy. Least for the last 15 years it's worked. May not sound like a long time but anymore folks staying married longer than 10 years is a big deal.
We have 3 kids all active in 4-H so when we do go out of town it's not just cattle and horses than need attention. No problem with the neighbors helping out with those but when you also have a goat, sheep, guinea pigs, hamsters, dog, cats, chickens, salamander, and the list goes on it starts to be (in my opinion anyway) more of an imposition to the neighbors than just "what is expected of a good neighbor".
I'm lucky that we have a hard as heck working neighbor kid (19yo.) that runs his own fence building business plus helps out on his folks farm and he goes sun up till sun down that watches our place when we are away.
I have to force him to take money but he finally understood when I told him if I did not have him to count on my marriage would be in serious trouble. I will usually just put some cash in a feed bucket with a note thanking him when we do leave town. Thankfully he has always been there to watch the place when we do leave but if he is ever not available we also have a couple of kids that live on farms that go to our church that is willing to watch the place for us as well.
J