I rented a pasture one year that we ran 150 pairs in (everything I had at the time plus some of a friends), they were in tall grass all year and everything came out looking like hell. I think the dominate cows and calves which were already larger got the choice feeds, and everyone else fell further behind. Now everything I have is in groups less that 40 pair. Much easier as we can supplement the later calves with a little hay, and any light groups as well. Since we haul everything to pasture, it is real easy to group them at spring turnout.
We run replacement heifers and steers together, never supplement much as they are on great grass, but the all seem to do well, I want good gain on both. Rotational grazing has helped a bunch-when we did the big pasture they were on the same place all year and the feed wasn't very uniform. It was real easy (all I did was drive by and check them once in a while, another guy irrigated it) but I will never do that again. Big places like that around here are expensive anyway.