Yea, I used it once. Did a pretty good job sealing a pin hole in a radiator. I don't know about your manifold, though. Is the manifold on a tractor or a car (truck)? If its aluminum I don't think anything is going to help short of replacing the manifold. If its corroded it will just spring a leak somewhere else. If its cast iron then its probably not the manifold thats leaking but more than likely a gasket and again the stop leak isn't going to help much.
Sorry I couldn't offer a better outcome.