hopalong":kuftk8lm said:
drank horse milk. goat milk, cow milk never had sheep milk anyone ever try it???
Evidence of effective scrapie transmission via colostrum and milk in sheep
BMC Veterinary Research 2013, 9:99 doi:10.1186/1746-6148-9-99
ISSN 1746-6148 Article type Research article Submission date 21 February 2013 Acceptance date 30 April 2013 Publication date 7 May 2013 Article/1746-6148/9/99
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Evidence of effective scrapie transmission via colostrum and milk in sheep
1 Specialist Scientific Support Department, Animal Health and Veterinary Laboratories Agency Weybridge, New Haw Addlestone, Surrey KT15 3NB, UK
2 Formerly – Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK
3 School of Veterinary and Biomedical Sciences, Murdoch University, South Street, Murdoch, WA 6150, Australia
4 TSE Department, Animal Health and Veterinary Laboratories Agency, New Haw, Addlestone, Surrey KT15 3NB, UK
Abstract
Background
Evidence for scrapie transmission from VRQ/VRQ ewes to lambs via milk was first reported in 2008 but in that study there were concerns that lateral transmission may have contributed to the high transmission rate observed since five control lambs housed with the milk recipients also became infected. This report provides further information obtained from two follow-up studies, one where milk recipients were housed separately after milk consumption to confirm the validity of the high scrapie transmission rate via milk and the second to assess any difference in infectivity from colostrum and subsequent milk. Protein misfolding cyclic amplification (PMCA) was also used to detect prion protein in milk samples as a comparison with the infectivity data and extended to milk samples from ewes without a VRQ allele.
Results
Seven pairs of lambs fed colostrum and milk individually from seven scrapie-affected sheep (pre-clinical or clinical) presented with disease-associated prion protein, PrPd, in rectal lymphoid tissue at 4–5 months of age. Five further pairs of lambs fed either colostrum or subsequent milk from five pre-clinical scrapie-affected sheep equally presented with PrPd in lymphoid tissue by 9 months of age. Nine sheep were lost due to intercurrent diseases but all remaining milk or colostrum recipients, including those in the original study with the lateral transmission controls, developed clinical signs of scrapie from 19 months of age and scrapie was confirmed by brain examination. Unexposed control sheep totalling 19 across all three studies showed no evidence of infection.
Scrapie PrP was amplified repeatedly by PMCA in all tested milk samples from scrapieaffected VRQ/VRQ sheep, and in one scrapie-affected ARQ/ARQ sheep. By contrast, milk
samples from five VRQ/VRQ and 11 ARQ/ARQ scrapie-free sheep did not have detectable scrapie PrP on repeated tests.
Conclusions
Feeding of milk from scrapie-affected sheep results in a high transmission rate in VRQ/VRQ sheep and both colostrum and milk transmit scrapie. Detection of scrapie prion protein in individual milk samples from scrapie-affected ewes confirms PMCA as a valuable in vitro test.
Keywords
Transmissible spongiform encephalopathy, Scrapie, Sheep, Milk, Colostrum, Transmission, PMCA, Prion protein, RAMALT, Copper
http://www.biomedcentral.com/content/pd ... 8-9-99.pdf
Tuesday, April 30, 2013 Transmission of classical scrapie via goat milk
Veterinary Record2013;172:455 doi:10.1136/vr.f2613
Letters
Ruminant Health
Transmission of classical scrapie via goat milk
Timm Konold1, Hugh A. Simmons1, Paul R. Webb1, Peter J. Bellerby1, Steve A. C. Hawkins1 and Lorenzo González2
+ Author Affiliations
1AHVLA – Weybridge, New Haw, Addlestone, Surrey KT15 3NB 2– Lasswade, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ
FOLLOWING reports that ovine scrapie (referred to here and subsequently as classical scrapie) can be transmitted from dams to lambs via milk (Konold and others 2008, Ligios and others 2011), we subsequently carried out a study to investigate whether caprine scrapie could also be transmitted via milk, using material collected from a field outbreak of scrapie in goats in the UK (González and others 2009). Lambs were selected as milk recipients from a closed flock of known scrapie-free status (Simmons and others 2009) because an assured scrapie-free source of goats was not available.
Due to the lack of published information about the susceptibility of sheep to caprine scrapie, a pilot study was conducted to determine whether sheep were susceptible to …
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The study is still ongoing but the current results confirm that the scrapie agent can also be transmitted via milk from goats. This reinforces the validity of the decision by the European Parliament in 2009 to prohibit the feeding of milk or milk products from classical scrapie-infected flocks or herds to small ruminants in general.
Timm Konold, Hugh A. Simmons,
please see full text @
http://veterinaryrecord.bmj.com/content ... tract?etoc
Sunday, February 10, 2013
Scientific Opinion on the risk of transmission of classical scrapie via in vivo derived embryo transfer in ovine animals
http://scrapie-usa.blogspot.com/2013/02 ... sk-of.html
Saturday, February 11, 2012
PrPSc Detection and Infectivity in Semen from Scrapie-Infected Sheep
http://transmissiblespongiformencephalo ... ty-in.html
Wednesday, January 18, 2012
BSE IN GOATS CAN BE MISTAKEN FOR SCRAPIE
February 1, 2012
http://transmissiblespongiformencephalo ... n-for.html
Envt.18: Mother to Offspring Transmission of Chronic Wasting Disease
tss
