Bottle calves yes. Especially the dairy breed bottle calves. A lot of bottle calf I’ve taken in came with a bad case of the runs and for whatever reason jersey calves seem to get it the worst. Probiotics and electrolytes I feed until they are stable and eating grain and hay or if they have the runs or have taken antibiotics for whatever reason. Whether it works or not I don’t know. When I first started taking in bottle calves I started with the sickest ones. Took in the ones that needed me most. A dairy farmer neighbour gave me a regiment, I’ve always followed it, my bottle calves have always thrived.