MLV Vaccine Temps ?

[Stocker Steve]

Had a MLV package delivered late at night in sub zero temps. It was hard the next morning. Got a replacement shipped.

The replacement showed up on Monday, with an orange Saturday delivery sticker on it. :frowns: So it sat over the weekend. Is this vaccine still good?

 

[Bright Raven]

All MLV Vaccines are temperature sensitive as you already know. What you have to do is read the minimum and maximum temperature limits and evaluate whether it exceeded those limits.

 

[Jeanne - Simme Valley]

I am sooo lucky. My vets office has a "drop ship" program. You have to order over $300 to use it and it is nicely discounted. You call it in to the office (or I type it & email), I have it at my door next day. They give their customers a huge catalog, so we have cat. #.
I am also sooo lucky that we have so many vets available. NY is the 3rd largest dairy state. Agriculture is the number 1 industry in NY. There are probably 4-5 vets offices within 10 miles of my farm. My vet has maybe 8 large animal vets & 2-3 small animal vets.

 

[wbvs58]

I have been told by drug companies that other types of live viral vaccines are a lot tougher than made out to be and can survive short durations at the wrong temp if used immediately and in their testing often heated them up to above room temp and then injected a small portion of a dose and got an immune response. However I would not use it unless desperate and even then would not use it in a situation where I would be relying on the result.

Ken

 

[Dempster]

Follow the recommendation of your supplier and the vaccine company. But for general information, MLV vaccines do better with temp extremes than killed products. Your MLV will generally have a freeze dried portion and a liquid diluent to mix with it. The freeze dried portion doesn't have the water in it that would freeze and cause as much damage to the resulting product. The liquid diluent would freeze and if it contains a portion of the vaccine, that portion could be damaged resulting in poor efficacy or increased adverse reactions. Some diluents are only sterile water or saline, those diluents should be able to freeze and thaw without issue.

If you are processing on a cold day and the product freezes after mixing, all bets are off.

 

[kenny thomas]

Follow the recommendation of your supplier and the vaccine company. But for general information, MLV vaccines do better with temp extremes than killed products. Your MLV will generally have a freeze dried portion and a liquid diluent to mix with it. The freeze dried portion doesn't have the water in it that would freeze and cause as much damage to the resulting product. The liquid diluent would freeze and if it contains a portion of the vaccine, that portion could be damaged resulting in poor efficacy or increased adverse reactions. Some diluents are only sterile water or saline, those diluents should be able to freeze and thaw without issue.

If you are processing on a cold day and the product freezes after mixing, all bets are off.

What Dempster just said. Freezing sterile water isn't an issue

 

[Bright Raven]

Follow the recommendation of your supplier and the vaccine company. But for general information, MLV vaccines do better with temp extremes than killed products. Your MLV will generally have a freeze dried portion and a liquid diluent to mix with it. The freeze dried portion doesn't have the water in it that would freeze and cause as much damage to the resulting product. The liquid diluent would freeze and if it contains a portion of the vaccine, that portion could be damaged resulting in poor efficacy or increased adverse reactions. Some diluents are only sterile water or saline, those diluents should be able to freeze and thaw without issue.

If you are processing on a cold day and the product freezes after mixing, all bets are off.

What Dempster just said. Freezing sterile water isn't an issue

Kenny, ole buddy, it is not always sterile water. The 5 FP viruses are in the freeze dried portion. But if it is a FP 5 VL5 (the 5 fetal protection viruses plus the Vibriosis and Leptospira bacterins), the liquid fraction contains a prepared, inactivated or adjuvanted bacterin. Perhaps killed. Nevertheless, freezing will ruin the bacterin component. So until we know what vaccine he is using, best to keep it within the recommended temperatures.