Inforce 3

[Bright Raven]

This is the kind of confusion I often experience with labeling.

The following is copied from the Manufacturer's (Zoetis) brochure packaged with Inforce 3. Notice the Indications for use state to administer to healthy cattle from 3 days old to older.

INFORCE 3®

Zoetis
Bovine Rhinotracheitis-Parainfluenza3-Respiratory Syncytial Virus Vaccine
Modified Live Virus
For intranasal use only
INDICATIONS: For vaccination of healthy cattle 3 days of age or older, including pregnant cows, to prevent respiratory disease caused by bovine respiratory syncytial virus (BRSV), and as an aid in preventing respiratory disease caused by infectious bovine rhinotracheitis (IBR) virus and parainfluenza3 (PI3) virus. A duration of immunity of at least 193 days has been demonstrated against IBR; duration of immunity against BRSV and PI3 has not been established.

On their website under Inforce 3, it states that it can be given to newborn calves. That was always my understanding, in fact, there was a lot written about giving it in the first 24 hours when the immune system can handle it. It should be noted that Inforce 3 is different than providing antibodies to a calf. Colostrum is a source of antibodies - Inforce 3 is NOT a source of antibodies, it is a vaccine that innoculates the calf with antigens. The antigens then illicit an immune response and the calf builds it's own antibodies. In contrast, First Defense is actually the same as colostrum.
First Defence boluses are made up of antibodies so no immune response occurs.

BTW: this might be interesting to those who also use Inforce 3.
A. You don't have to put 1 mL of the mix in each nostril. The video on their website says to put 2 mL in one nostril.
B. Don't tilt the calf's head up. It causes the liquid to run back into the trachea.

 

[Bright Raven]

I have resolved the discrepancy between the Manufacturer's Label in the packaging and the instructions on the website. The information stated in the Indications on the label are required by law to conform to the methods performed during the efficacy study. In the efficacy study for approval of Inforce 3, three day old calves were used. Therefore, the Indications adhere to the study.

The Customer Service Veterinarian stated that the vaccine is effective in newborn calves.

 

[midTN_Brangusman]

We give it at birth when we weigh/tag. one squirt in one nostril.

 

[Bright Raven]

Something worth noting that came out of the conversation: it was once thought that a calf did not respond to antigens during early postpartum. The primary concept was that their defense to pathogens was a result of antibodies absorbed from colostrum. In my conversation with one of the PhD customer service experts at Zoetis, she explained that more recent research has demonstrated that a calf can in fact have an immune response in the nasal cavity because of special tissue in the nasal sinuses. This is why we are seeing more intranasal vaccines for newborns. Also, you don't have to stress out if you don't use the intranasal during the first day of life. In fact, you can use an intranasal at any time since the nasal cavity has tissue that responds to antigens.

It is also noteworthy to keep in mind, there is a vast difference between an immune response and providing a direct supply of antibodies. The example I used above was first defense. First Defense provides direct antibodies to E. Coli and Coronavirus. It is not a vaccine. Inforce 3 is a vaccine and the calf produces antibodies in response to the vaccine (antigens) in the special tissue in the nasal cavity.

 

[WFfarm]

In the last few years our feeder calf buyer has requested we treat with Inforce3 a week before they ship. It was recommended by his vet and he says he's had a noticeable decrease in the number of respiratory issues and snotty noses in the feedlot. My question is, is this overkill because we already vaccinate and booster for the IBR, BVD, PI3 and BRSV when we wean them? Does the nasal treatment give an additional protection than the shots? Maybe an added boost response during the stress of loading and shipping, or covers the few that didn't get full antibodies? He's the customer so we kindly comply.

 

[Bright Raven]

In the last few years our feeder calf buyer has requested we treat with Inforce3 a week before they ship. It was recommended by his vet and he says he's had a noticeable decrease in the number of respiratory issues and snotty noses in the feedlot. My question is, is this overkill because we already vaccinate and booster for the IBR, BVD, PI3 and BRSV when we wean them? Does the nasal treatment give an additional protection than the shots? Maybe an added boost response during the stress of loading and shipping, or covers the few that didn't get full antibodies? He's the customer so we kindly comply.

It is overkill if they are already appropriately vaccinated for IBR, PI3 and BRSV. The Inforce 3 nasal vaccine illicits a good immune response and it is an MLV vaccine. But at the end of the day, if the cattle in question are vaccinated for those 3 viruses and the associated strains, then there is nothing added. As you say, if that is what the buyer demands, then you are correct to comply.

Something to remember, vaccination is the only effective way to defend against viruses. Antibiotics are not effective except to treat secondary bacterial infections. I would think the buyer would also be concerned about Mannheimia haemolytica and Pasteurella multocida but at least the buyer can treat those two bacteria.

 

[Ebenezer]

You have to remember that the efficacy of vaccines is not going to be 100%. There was some data years ago that it was around 85%. Give two or three shots at a time and it can be lower. I am not here to argue but our Vet recommended black leg (CDT) separate from all others for about 3 weeks because it can occupy so much of the immune system that all other shots will get minimal reaction and develop very little immunity to protect the animal. So no, the buyer is smart and is trying to minimize loss better than the standard protocol.

 

[Allenw]

Ebenezer I think I already knew that about multiple vaccines at one time, thanks ffor bringing it up. I don't think I knew the specific info on the bla k leg vaccine, it may make me rethink some things.

 

[Buck Randall]

In the last few years our feeder calf buyer has requested we treat with Inforce3 a week before they ship. It was recommended by his vet and he says he's had a noticeable decrease in the number of respiratory issues and snotty noses in the feedlot. My question is, is this overkill because we already vaccinate and booster for the IBR, BVD, PI3 and BRSV when we wean them? Does the nasal treatment give an additional protection than the shots? Maybe an added boost response during the stress of loading and shipping, or covers the few that didn't get full antibodies? He's the customer so we kindly comply.

You're correct on the bolded, but intranasal vaccines also provide a different kind of immunity than the injectable vaccines. Injectable vaccines stimulate the production of antibodies that circulate in the bloodstream, while intranasal vaccines stimulate production of a different kind of antibody that is secreted on the mucosal surfaces of the respiratory tract. This immunity is shorter lived, but more effective as a first-line defense against respiratory disease.

 

[Bright Raven]

I gave Inforce 3 at birth. The calves are now about 2 to 2 1/2 months old. Just this week I ran them all through and gave them a second squirt of Inforce 3. Next week, I plan to give them an injectable for Mannheimia haemolytica and Pasteurella multocida. Pulmo-Guard PHM-1. That sets me up pretty good respiratory protection for the winter. At weaning, I will give a full suite of fetal Protection - probably Bovi Shield Gold FP 5 L5 HB.

 

[kenny thomas]

So are you buying the 25 single dose packs and how much are they?

 

[Bright Raven]

So are you buying the 25 single dose packs and how much are they?

I buy the 25 single dose vials. That way I just mix one when a calf is born. A box of 25 doses is $43.69.

If you are working a lot of animals at one time, they make an aerosol spray device. You can attach a 50 dose bottle and spray a dose up the nostril. I haven't used it but there is a video on the Zoetis website.

 

[kenny thomas]

So are you buying the 25 single dose packs and how much are they?

I buy the 25 single dose vials. That way I just mix one when a calf is born. A box of 25 doses is $43.69.

If you are working a lot of animals at one time, they make an aerosol spray device. You can attach a 50 dose bottle and spray a dose up the nostril. I haven't used it but there is a video on the Zoetis website.

I use single but the cheapest I can seem to find it is $48.

 

[Bright Raven]

So are you buying the 25 single dose packs and how much are they?

I buy the 25 single dose vials. That way I just mix one when a calf is born. A box of 25 doses is $43.69.

If you are working a lot of animals at one time, they make an aerosol spray device. You can attach a 50 dose bottle and spray a dose up the nostril. I haven't used it but there is a video on the Zoetis website.

I use single but the cheapest I can seem to find it is $48.

I order from Jeffers. I put together my whole vaccine order so it spreads out the cost for next day air shipping.

 

[kenny thomas]

I buy the 25 single dose vials. That way I just mix one when a calf is born. A box of 25 doses is $43.69.

If you are working a lot of animals at one time, they make an aerosol spray device. You can attach a 50 dose bottle and spray a dose up the nostril. I haven't used it but there is a video on the Zoetis website.

I use single but the cheapest I can seem to find it is $48.

I order from Jeffers. I put together my whole vaccine order so it spreads out the cost for next day air shipping.

Thanks. I use around 200 doses a year so rarely order it all at once. May have to start.

 

[Bright Raven]

This is from the Zoetis website. Worth watching if you are planning on using or currently use Inforce 3.

https://youtu.be/VWz6N5BPO9w

 

[sim.-ang.king]

So are you buying the 25 single dose packs and how much are they?

I buy the 25 single dose vials. That way I just mix one when a calf is born. A box of 25 doses is $43.69.

If you are working a lot of animals at one time, they make an aerosol spray device. You can attach a 50 dose bottle and spray a dose up the nostril. I haven't used it but there is a video on the Zoetis website.

I went to using just a prima tech vaccinator with the nose cannula stuck in it, when working them through the chute.

Also why do I get so many of those dang nose cannulas? Every time I order some bottles from valley vet I get way more than I need.

On a side note, if someone needs some unused nose cannulas, I have some for sale. Only $5.99 per bag plus shipping. :lol:

 

[Bright Raven]

So are you buying the 25 single dose packs and how much are they?

I buy the 25 single dose vials. That way I just mix one when a calf is born. A box of 25 doses is $43.69.

If you are working a lot of animals at one time, they make an aerosol spray device. You can attach a 50 dose bottle and spray a dose up the nostril. I haven't used it but there is a video on the Zoetis website.

I went to using just a prima tech vaccinator with the nose cannula stuck in it, when working them through the chute.

Also why do I get so many of those dang nose cannulas? Every time I order some bottles from valley vet I get way more than I need.

On a side note, if someone needs some unused nose cannulas, I have some for sale. Only $5.99 per bag plus shipping. :lol:

The prima tech vaccinator is a good idea. In the video, they are using a pumping device which appears to be basically the same tool to spray the dose into the nostril. I suspect they make one just for intranasal applications.

 

[Jeanne - Simme Valley]

Also - the nasal products "kick in" their immune system, so it helps them fight off exposure during the stress.
I use it when a calf is just feeling a little puny. It helps them fight off a bug, instead of treating with anbiotics - or when we are going to show a calf for the first time.
The 85% response is why I give BS5L5HB 30 days apart on my calves. You have to give a booster for the BRSV, so instead of sticking a needle in them for 1 thing, I hit them with the full vaccine.
I give Inforce 3 to my newborns, but I had been warned to give it on day 1 or wait until like day 4. So, this is not true? Good to know.

 

[Bright Raven]

I give Inforce 3 to my newborns, but I had been warned to give it on day 1 or wait until like day 4. So, this is not true? Good to know.

Jeanne. Inforce 3 can be given at any time. Remember, this is not an infusion of antibodies. It is a vaccine. Colostrum should be given in the first 12 hours if possible but that is a function of the uptake of antibodies. Inforce 3 initiates an immune response - the vaccine acts as antigens and the calf produces the antibodies. According to what the expert at Zoetis told me, a calf has an immune response to the intranasal Inforce 3 at anytime.