midtn,
Yes, endophyte-infected fescue can be a problem. But, speaking from past experience, I would never again kill out an established stand of good ol' 'dirty' KY-31 - I'd just manage it - keeping a good stand of legumes(clovers, lespedezas) going to 'dilute' out deleterious effects, while selecting cattle that can perform on it.
Back in the day, when I was still stupid enough to chase 'giverment' dollars from FSA, NRCS, etc., I killed out my KY 31 - and also reclaimed a creekbottom field that had been in corn/soybean rotation for years - planting the orchardgrass/timothy/red clover mix THEY require, though I also mixed in some endophyte-free fescue 'on my own dime'. Looked good the first year...but, timothy only lasts 1-2 years here, endophyte-free fescue turns 'toes-up' at the first hint of drought or overgrazing, red clover only lasts 2-3 years at best, and orchardgrass is about the last thing my cows will eat when they're rotating through the paddocks.
So...I've ended up having to come back, within 3-5 years and re-plant(again, on my own dime). Have done it with Max-Q(novel endophyte) and Persist orchardgrass - both of which have performed well in combination in grazing trials down in Lawrence Co., TN. Probably would have just gone back with KY-31, if it weren't for the wife's thought that she might, one day, want to breed some mares and raise some foals. Certainly was more expensive to seed Max-Q or any of the other novel endophyte varieties than KY-31, but it's performed well here.
Are my cows performing better on Max-Q than they would on KY-31, and was it a wise decision to go that route? I don't know; and without any significant stand of KY-31 on the place anymore, I don't have any way to compare.
Studies have shown that there's minimal, if any, 'migration' of undesirable endophyte into endophyte-free or 'friendly-endophyte' stands from neighboring fields - but if you don't have a 1.5-2 year span between killing off the original high-endophyte stand - and preventing seedlings of that infected stand from becoming established(the endophyte in seed pretty well dies off in the seed after 2 years) - you can have significant 'volunteer' endophyte-infected fescue popping up in a renovated field.