Sent: Saturday, December 11, 2010 3:17 PM Subject: Species-barrier-independent prion replication in apparently resistant species
Species-barrier-independent prion replication in apparently resistant species
Pertenece a: UCL University College London Eprints
Descripción: Transmission of prions between mammalian species is thought to be limited by a "species barrier," which depends on differences in the primary structure of prion proteins in the infecting inoculum and the host, Here we demonstrate that a strain of hamster prions thought to be nonpathogenic for conventional mice leads to prion replication to high levels in such mice but without causing clinical disease. Prions pathogenic in both mice and hamsters are produced. These results demonstrate the existence of subclinical forms of prion infection with important public health implications, both with respect to iatrogenic transmission from apparently healthy humans and dietary exposure to cattle and other species exposed to bovine spongiform encephalopathy prions, Current definitions of the species barrier, which have been based on clinical endpoints, need to be fundamentally reassessed.
Autor(es): Hill, AF - Joiner, S - Linehan, J - Desbruslais, M - Lantos, PL - Collinge, J -
Id.: 52395313
Versión: 1.0
Estado: Final
Palabras clave: TRANSMISSIBLE MINK ENCEPHALOPATHY, CREUTZFELDT - JAKOB - DISEASE, FATAL FAMILIAL INSOMNIA, STRAIN VARIATION, TRANSGENIC MICE, SCRAPIE INFECTIVITY, HAMSTER SCRAPIE, VARIANT CJD, BSE AGENT, PROTEIN -
Tipo de recurso: Article -
Tipo de Interactividad: Expositivo
Nivel de Interactividad: muy bajo
Audiencia: Estudiante - Profesor - Autor -
Estructura: Atomic
Coste: no
Copyright: sí
Requerimientos técnicos: Browser: Any -
Fecha de contribución: 10-dic-2010
Contacto:
http://biblioteca.universia.net/html_bu ... 95313.html
for those interested, see more here with comments........
Saturday, December 11, 2010
Species-barrier-independent prion replication in apparently resistant species
http://transmissiblespongiformencephalo ... prion.html
Sunday, December 12, 2010
Predominant Involvement of the Cerebellum in Guinea Pigs Infected with Bovine Spongiform Encephalopathy (BSE)
Journal of Comparative Pathology Article in Press
http://creutzfeldt-jakob-disease.blogsp ... ellum.html
TSS
Species-barrier-independent prion replication in apparently resistant species
Pertenece a: UCL University College London Eprints
Descripción: Transmission of prions between mammalian species is thought to be limited by a "species barrier," which depends on differences in the primary structure of prion proteins in the infecting inoculum and the host, Here we demonstrate that a strain of hamster prions thought to be nonpathogenic for conventional mice leads to prion replication to high levels in such mice but without causing clinical disease. Prions pathogenic in both mice and hamsters are produced. These results demonstrate the existence of subclinical forms of prion infection with important public health implications, both with respect to iatrogenic transmission from apparently healthy humans and dietary exposure to cattle and other species exposed to bovine spongiform encephalopathy prions, Current definitions of the species barrier, which have been based on clinical endpoints, need to be fundamentally reassessed.
Autor(es): Hill, AF - Joiner, S - Linehan, J - Desbruslais, M - Lantos, PL - Collinge, J -
Id.: 52395313
Versión: 1.0
Estado: Final
Palabras clave: TRANSMISSIBLE MINK ENCEPHALOPATHY, CREUTZFELDT - JAKOB - DISEASE, FATAL FAMILIAL INSOMNIA, STRAIN VARIATION, TRANSGENIC MICE, SCRAPIE INFECTIVITY, HAMSTER SCRAPIE, VARIANT CJD, BSE AGENT, PROTEIN -
Tipo de recurso: Article -
Tipo de Interactividad: Expositivo
Nivel de Interactividad: muy bajo
Audiencia: Estudiante - Profesor - Autor -
Estructura: Atomic
Coste: no
Copyright: sí
Requerimientos técnicos: Browser: Any -
Fecha de contribución: 10-dic-2010
Contacto:
http://biblioteca.universia.net/html_bu ... 95313.html
for those interested, see more here with comments........
Saturday, December 11, 2010
Species-barrier-independent prion replication in apparently resistant species
http://transmissiblespongiformencephalo ... prion.html
Sunday, December 12, 2010
Predominant Involvement of the Cerebellum in Guinea Pigs Infected with Bovine Spongiform Encephalopathy (BSE)
Journal of Comparative Pathology Article in Press
http://creutzfeldt-jakob-disease.blogsp ... ellum.html
TSS
