Our flukes are primarily Fasciola magna, which apparently is not affected, even the adults, by the ivermection/clorsulon combination drugs for flukes (so the vet says, I haven't verified that). Apparently, Valbazen may work. But the primary drug of choice, if it were readily available in N. America would be Fasinex.
Prevention is more of the key. Fencing/draining wet holes helps a lot. Although I don't hunt, I am very open to having people fill their tags on my properties, to keep the white-tail population in check. So if anyone on here ever wants to hunt big-bodied white tails in Northwestern Ontario, I will be more than willing to set you up on this place.
Being a biologist, I was asked for insight when a research study was done through the University of Manitoba's Agriculture Department involving flukes. They looked at livers of cattle and feed from operations across Manitoba. What they found was that the fluke infestation followed a gradient effect. The flukes were the worst in the southeast corner of the province (lowland/wet/marshy) and were completely gone in Central Manitoba (dry, rolling plains). So the higher and drier you are, the less likely you will have flukes. Although their were pockets of flukes in the higher/drier regions of the province, many of the infestations were the result of contaminated feed being trucked in from the southeast part of the province.
Northern Minnesota has the same issue with flukes as us, and by the time you hit central ND, nothing about liver flukes.
We've butchered many an animal that not only had a cooked liver, but also lungs and track marks on the inner lining of the carcass as well. One 2 year old heifer once had only one good lung. Beautiful looking heifer on the outside, but basically only working on one lung.