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Tetanus
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<blockquote data-quote="Lucky_P" data-source="post: 1807160" data-attributes="member: 12607"><p>Let's have a short immunology lesson:</p><p>Tetanus toxoid is a preparation of the toxin produced by Clostridium tetani which has been denatured so that it can no longer exert its effect - but will still stimulate the animal's immune system to mount an immune response (antibodies and immune cell populations directed against the tetanus toxin) so that they are protected against subsequent exposures.</p><p>Tetanus antitoxin is a preparation of anti-tetanus toxin antibodies, derived from the serum of horses that have been hyper-immunized with tetanus toxoid, such that they have very high levels of anti-tetanus toxin antibodies in their blood serum. </p><p></p><p>So... tetanus antitoxin provides 'immediate' - but temporary - protection against a 'known' potential exposure. </p><p>Tetanus toxoid, like any other vaccine/bacterin/toxoid, requires a period of time - and a booster, 2-4 weeks after the initial dose - in order for the animal's immune system to respond to provide optimal protection against the tetanus toxin. </p><p>Tetanus antitoxin and tetanus toxoid can be administered at the same time... the antitoxin will not prevent the animal's immune system from responding to the denatured toxin(toxoid) - but to get optimal (and essentially, permanent) protection, a toxoid booster is still needed.</p><p></p><p>I've seen some real trainwrecks in groups of bulls banded and given a dose of tetanus toxoid at that time... the cattle 'lost the race'... being unable to mount an effective immune response before the C.tetani organisms begin producing tetanus toxin.</p></blockquote><p></p>
[QUOTE="Lucky_P, post: 1807160, member: 12607"] Let's have a short immunology lesson: Tetanus toxoid is a preparation of the toxin produced by Clostridium tetani which has been denatured so that it can no longer exert its effect - but will still stimulate the animal's immune system to mount an immune response (antibodies and immune cell populations directed against the tetanus toxin) so that they are protected against subsequent exposures. Tetanus antitoxin is a preparation of anti-tetanus toxin antibodies, derived from the serum of horses that have been hyper-immunized with tetanus toxoid, such that they have very high levels of anti-tetanus toxin antibodies in their blood serum. So... tetanus antitoxin provides 'immediate' - but temporary - protection against a 'known' potential exposure. Tetanus toxoid, like any other vaccine/bacterin/toxoid, requires a period of time - and a booster, 2-4 weeks after the initial dose - in order for the animal's immune system to respond to provide optimal protection against the tetanus toxin. Tetanus antitoxin and tetanus toxoid can be administered at the same time... the antitoxin will not prevent the animal's immune system from responding to the denatured toxin(toxoid) - but to get optimal (and essentially, permanent) protection, a toxoid booster is still needed. I've seen some real trainwrecks in groups of bulls banded and given a dose of tetanus toxoid at that time... the cattle 'lost the race'... being unable to mount an effective immune response before the C.tetani organisms begin producing tetanus toxin. [/QUOTE]
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