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NCBA, R-CALF, COOL, USDA (No Politics!)
Ranchers in Texas Need to Pay Close Attention to CWD TSE Prion
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<blockquote data-quote="TexasJerseyMilker" data-source="post: 1848936" data-attributes="member: 42782"><p>That would be very important to find out. Here is a study researched that topic, first and last paragraph.</p><p>They let cattle graze in pens with CWB infected deer and elk for 10 years. Also gave some cattle large oral doses of CWD infected mule deer brains and also watched over those animals for 10 years. Shockingly, some cattle (not all), did developed BSE-like disease 2 to 5 years after CWD brain material was injected directly into their brains</p><p></p><p><strong>Non Technical Summary</strong></p><p>CWD is a transmissible spongiform encephalopathy that infects wild and farmed deer and elk. It is related to the prion diseases scrapie of sheep and BSE of cattle. It has been shown that some cattle can develop a BSE-like disease 2 to 5 years afterwards when this CWD brain material is injected intracerebrally, but it is not known if a more natural route of exposure to the infectious agent can transmit the disease to cattle. Since cattle can encounter CWD-infected deer and/or elk, or the long-lasting infectious prion shed by them, on shared grazing range, a realistic assessment of the possibility they could become infected is needed. The BSE epidemic in the UK in the 1980's and subsequent transmission of the BSE prion to humans through infected beef products created an awareness of the possible economic and public health impacts of a similar occurrence in the U.S. This research seeks to determine if domestic cattle that have been kept in physical contact with chronic wasting disease-infected deer and elk or with contaminated premises for ten years also became infected. This research project will analyze brain and other tissues from the CWD-exposed cattle, none of which have died or developed clinical signs of disease, to determine if transmission has occurred. A separate project will examine cattle were given a large oral dose of macerated brain tissues from CWD-infected mule deer ten years ago. Whether CWD in cattle would become infectious for humans is not known, but it is a risk factor that would need to be evaluated.</p><p></p><p></p><p><strong>Impacts</strong></p><p>This study investigated the risk of domestic cattle developing a transmissible spongiform encephalopathy (TSE) after oral inoculation followed by a long incubation period, or by long-term natural exposure to cervids infected with chronic wasting disease (CWD). Previously,ten cattle were given large oral doses of pooled brain material from CWD-infected mule deer in late August 1997 and housed in isolation at the Wyoming State Veterinary Laboratory until September 2007. Two additional groups of cattle were penned outdoors with CWD-infected deer and elk or in CWD-contaminated premises at Colorado Division of Wildlife (n=11) and Wyoming Game and Fish Department (n=10) research facilities during the same ten-year period. These conditions simulated exposure routes that cattle in North America might encounter if they are raised or grazed in areas where free-ranging or captive deer and elk are infected with CWD. During the current project, all exposed and three untreated control cattle were killed, and select tissues were collected at necropsy. Samples from each animal were analyzed for the diagnostic hallmarks of TSEs by histological examination, immunohistochemistry and Western blot. DNA sequences were determined for the cellular prion protein gene in each animal. No proteinase-K resistant prion protein or anti-PrP immunoreactive IHC signals were detected in any tissues of exposed or control animals. None of these results, taken individually or together, support a diagnosis of TSE in cattle inoculated orally with a high dose of infectious CWD material or continually exposed by cohabitation with infected deer or elk, or transmission from contaminated premises despite an incubation period of up to 10 or 11 years. </p><p></p><p>[URL unfurl="true"]https://portal.nifa.usda.gov/web/crisprojectpages/0211708-susceptibility-of-domestic-cattle-to-chronic-wasting-disease-by-oral-inoculation-and-natural-exposure-final-phase-10-year-study.html[/URL]</p></blockquote><p></p>
[QUOTE="TexasJerseyMilker, post: 1848936, member: 42782"] That would be very important to find out. Here is a study researched that topic, first and last paragraph. They let cattle graze in pens with CWB infected deer and elk for 10 years. Also gave some cattle large oral doses of CWD infected mule deer brains and also watched over those animals for 10 years. Shockingly, some cattle (not all), did developed BSE-like disease 2 to 5 years after CWD brain material was injected directly into their brains [B]Non Technical Summary[/B] CWD is a transmissible spongiform encephalopathy that infects wild and farmed deer and elk. It is related to the prion diseases scrapie of sheep and BSE of cattle. It has been shown that some cattle can develop a BSE-like disease 2 to 5 years afterwards when this CWD brain material is injected intracerebrally, but it is not known if a more natural route of exposure to the infectious agent can transmit the disease to cattle. Since cattle can encounter CWD-infected deer and/or elk, or the long-lasting infectious prion shed by them, on shared grazing range, a realistic assessment of the possibility they could become infected is needed. The BSE epidemic in the UK in the 1980's and subsequent transmission of the BSE prion to humans through infected beef products created an awareness of the possible economic and public health impacts of a similar occurrence in the U.S. This research seeks to determine if domestic cattle that have been kept in physical contact with chronic wasting disease-infected deer and elk or with contaminated premises for ten years also became infected. This research project will analyze brain and other tissues from the CWD-exposed cattle, none of which have died or developed clinical signs of disease, to determine if transmission has occurred. A separate project will examine cattle were given a large oral dose of macerated brain tissues from CWD-infected mule deer ten years ago. Whether CWD in cattle would become infectious for humans is not known, but it is a risk factor that would need to be evaluated. [B]Impacts[/B] This study investigated the risk of domestic cattle developing a transmissible spongiform encephalopathy (TSE) after oral inoculation followed by a long incubation period, or by long-term natural exposure to cervids infected with chronic wasting disease (CWD). Previously,ten cattle were given large oral doses of pooled brain material from CWD-infected mule deer in late August 1997 and housed in isolation at the Wyoming State Veterinary Laboratory until September 2007. Two additional groups of cattle were penned outdoors with CWD-infected deer and elk or in CWD-contaminated premises at Colorado Division of Wildlife (n=11) and Wyoming Game and Fish Department (n=10) research facilities during the same ten-year period. These conditions simulated exposure routes that cattle in North America might encounter if they are raised or grazed in areas where free-ranging or captive deer and elk are infected with CWD. During the current project, all exposed and three untreated control cattle were killed, and select tissues were collected at necropsy. Samples from each animal were analyzed for the diagnostic hallmarks of TSEs by histological examination, immunohistochemistry and Western blot. DNA sequences were determined for the cellular prion protein gene in each animal. No proteinase-K resistant prion protein or anti-PrP immunoreactive IHC signals were detected in any tissues of exposed or control animals. None of these results, taken individually or together, support a diagnosis of TSE in cattle inoculated orally with a high dose of infectious CWD material or continually exposed by cohabitation with infected deer or elk, or transmission from contaminated premises despite an incubation period of up to 10 or 11 years. [URL unfurl="true"]https://portal.nifa.usda.gov/web/crisprojectpages/0211708-susceptibility-of-domestic-cattle-to-chronic-wasting-disease-by-oral-inoculation-and-natural-exposure-final-phase-10-year-study.html[/URL] [/QUOTE]
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Ranchers in Texas Need to Pay Close Attention to CWD TSE Prion
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