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NCBA, R-CALF, COOL, USDA (No Politics!)
Ranchers in Texas Need to Pay Close Attention to CWD TSE Prion
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<blockquote data-quote="flounder" data-source="post: 1840214" data-attributes="member: 3519"><p>Price of TSE Prion Poker goes up substantially, all you cattle ranchers and such, better pay close attention here...terry</p><p></p><p>Transmission of the chronic wasting disease agent from elk to cattle after oronasal exposure</p><p></p><p>Justin Greenlee, Jifeng Bian, Zoe Lambert, Alexis Frese, and Eric Cassmann Virus and Prion Research Unit, National Animal Disease Center, USDA-ARS, Ames, IA, USA </p><p></p><p>Aims: The purpose of this study was to determine the susceptibility of cattle to chronic wasting disease agent from elk. </p><p></p><p>Conclusions: Cattle with the E211K polymorphism are susceptible to the CWD agent after oronasal exposure of 0.2 g of infectious material. </p><p></p><p>"Cattle with the E211K polymorphism are susceptible to the CWD agent after oronasal exposure of 0.2 g of infectious material."</p><p></p><p>=====end</p><p></p><p>Strain characterization of chronic wasting disease in bovine-PrP transgenic mice </p><p></p><p>Conclusions: Altogether, these results exhibit the diversity of CWD strains present in the panel of CWD isolates and the ability of at least some CWD isolates to infect bovine species. Cattle being one of the most important farming species, this ability represents a potential threat to both animal and human health, and consequently deserves further study. </p><p></p><p>"Altogether, these results exhibit the diversity of CWD strains present in the panel of CWD isolates and the ability of at least some CWD isolates to infect bovine species. Cattle being one of the most important farming species, this ability represents a potential threat to both animal and human health, and consequently deserves further study."</p><p></p><p>=====end</p><p></p><p><u><a href="https://prion2023.org/wp-content/uploads/2023/10/Meeting-book-final-version2.pdf" target="_blank">https://prion2023.org/wp-content/uploads/2023/10/Meeting-book-final-version2.pdf</a></u></p><p></p><p></p><p></p><p>cwd scrapie pigs oral routes </p><p></p><p>***> However, at 51 months of incubation or greater, 5 animals were positive by one or more diagnostic methods. Furthermore, positive bioassay results were obtained from all inoculated groups (oral and intracranial; market weight and end of study) suggesting that swine are potential hosts for the agent of scrapie. <*** </p><p></p><p>>*** Although the current U.S. feed ban is based on keeping tissues from TSE infected cattle from contaminating animal feed, swine rations in the U.S. could contain animal derived components including materials from scrapie infected sheep and goats. These results indicating the susceptibility of pigs to sheep scrapie, coupled with the limitations of the current feed ban, indicates that a revision of the feed ban may be necessary to protect swine production and potentially human health. <*** </p><p></p><p>***> Results: PrPSc was not detected by EIA and IHC in any RPLNs. All tonsils and MLNs were negative by IHC, though the MLN from one pig in the oral <6 month group was positive by EIA. PrPSc was detected by QuIC in at least one of the lymphoid tissues examined in 5/6 pigs in the intracranial <6 months group, 6/7 intracranial >6 months group, 5/6 pigs in the oral <6 months group, and 4/6 oral >6 months group. Overall, the MLN was positive in 14/19 (74%) of samples examined, the RPLN in <u>8/18</u> (44%), and the tonsil in 10/25 (40%). </p><p></p><p>***> Conclusions: This study demonstrates that PrPSc accumulates in lymphoid tissues from pigs challenged intracranially or orally with the CWD agent, and can be detected as early as 4 months after challenge. CWD-infected pigs rarely develop clinical disease and if they do, they do so after a long incubation period. This raises the possibility that CWD-infected pigs could shed prions into their environment long before they develop clinical disease. Furthermore, lymphoid tissues from CWD-infected pigs could present a potential source of CWD infectivity in the animal and human food chains. </p><p></p><p><u><a href="https://www.ars.usda.gov/research/publications/publication/?seqNo115=353091" target="_blank">https://www.ars.usda.gov/research/publications/publication/?seqNo115=353091</a></u></p><p><u></u></p><p><u><a href="https://www.ars.usda.gov/research/project/?accnNo=432011&fy=2017" target="_blank">https://www.ars.usda.gov/research/project/?accnNo=432011&fy=2017</a></u></p><p><u></u></p><p><u><a href="https://www.ars.usda.gov/research/publications/publication/?seqNo115=337105" target="_blank">https://www.ars.usda.gov/research/publications/publication/?seqNo115=337105</a></u></p><p></p><p>Conclusions: This study demonstrates that PrPSc accumulates in lymphoid tissues from pigs challenged intracranially or orally with the CWD agent, and can be detected as early as 4 months after challenge. CWD-infected pigs rarely develop clinical disease and if they do, they do so after a long incubation period. This raises the possibility that CWD-infected pigs could shed prions into their environment long before they develop clinical disease. Furthermore, lymphoid tissues from CWD-infected pigs could present a potential source of CWD infectivity in the animal and human food chains.</p><p></p><p><u><a href="https://www.ars.usda.gov/research/publications/publication/?seqNo115=337105" target="_blank">https://www.ars.usda.gov/research/publications/publication/?seqNo115=337105</a></u></p><p></p><p>THIS MUST CHANGE ASAP! </p><p></p><p>"For elk and deer considered at high risk for CWD, the FDA recommends that these animals do not enter the animal feed system. However, this recommendation is guidance and not a requirement by law."… </p><p></p><p>Snip…</p><p></p><p>please see my full submission with reference materials… 300NG is enough to transmit cwd to deer by oral route!</p><p></p><p>Monday, November 13, 2023 </p><p></p><p>Food and Drug Administration's BSE Feed Regulation (21 CFR <u>589.2000</u>) Singeltary Another Request for Update 2023 </p><p></p><p><u><a href="https://fdabse589.blogspot.com/2023/11/food-and-drug-administrations-bse-feed.html" target="_blank">https://fdabse589.blogspot.com/2023/11/food-and-drug-administrations-bse-feed.htm</a></u></p><p></p><p>THIS MUST CHANGE ASAP! </p><p></p><p>"For elk and deer considered at high risk for CWD, the FDA recommends that these animals do not enter the animal feed system. However, this recommendation is guidance and not a requirement by law."… </p><p></p><p>Snip…</p><p></p><p>please see my full submission with reference materials… 300NG is enough to transmit cwd to deer by oral route!</p><p></p><p>Monday, November 13, 2023 </p><p></p><p>Food and Drug Administration's BSE Feed Regulation (21 CFR <u>589.2000</u>) Singeltary Another Request for Update 2023 </p><p></p><p><u><a href="https://fdabse589.blogspot.com/2023/11/food-and-drug-administrations-bse-feed.html" target="_blank">https://fdabse589.blogspot.com/2023/11/food-and-drug-administrations-bse-feed.htm</a></u></p><p><u></u></p><p><u>terry</u></p></blockquote><p></p>
[QUOTE="flounder, post: 1840214, member: 3519"] Price of TSE Prion Poker goes up substantially, all you cattle ranchers and such, better pay close attention here...terry Transmission of the chronic wasting disease agent from elk to cattle after oronasal exposure Justin Greenlee, Jifeng Bian, Zoe Lambert, Alexis Frese, and Eric Cassmann Virus and Prion Research Unit, National Animal Disease Center, USDA-ARS, Ames, IA, USA Aims: The purpose of this study was to determine the susceptibility of cattle to chronic wasting disease agent from elk. Conclusions: Cattle with the E211K polymorphism are susceptible to the CWD agent after oronasal exposure of 0.2 g of infectious material. "Cattle with the E211K polymorphism are susceptible to the CWD agent after oronasal exposure of 0.2 g of infectious material." =====end Strain characterization of chronic wasting disease in bovine-PrP transgenic mice Conclusions: Altogether, these results exhibit the diversity of CWD strains present in the panel of CWD isolates and the ability of at least some CWD isolates to infect bovine species. Cattle being one of the most important farming species, this ability represents a potential threat to both animal and human health, and consequently deserves further study. "Altogether, these results exhibit the diversity of CWD strains present in the panel of CWD isolates and the ability of at least some CWD isolates to infect bovine species. Cattle being one of the most important farming species, this ability represents a potential threat to both animal and human health, and consequently deserves further study." =====end [U][URL]https://prion2023.org/wp-content/uploads/2023/10/Meeting-book-final-version2.pdf[/URL][/U] cwd scrapie pigs oral routes ***> However, at 51 months of incubation or greater, 5 animals were positive by one or more diagnostic methods. Furthermore, positive bioassay results were obtained from all inoculated groups (oral and intracranial; market weight and end of study) suggesting that swine are potential hosts for the agent of scrapie. <*** >*** Although the current U.S. feed ban is based on keeping tissues from TSE infected cattle from contaminating animal feed, swine rations in the U.S. could contain animal derived components including materials from scrapie infected sheep and goats. These results indicating the susceptibility of pigs to sheep scrapie, coupled with the limitations of the current feed ban, indicates that a revision of the feed ban may be necessary to protect swine production and potentially human health. <*** ***> Results: PrPSc was not detected by EIA and IHC in any RPLNs. All tonsils and MLNs were negative by IHC, though the MLN from one pig in the oral <6 month group was positive by EIA. PrPSc was detected by QuIC in at least one of the lymphoid tissues examined in 5/6 pigs in the intracranial <6 months group, 6/7 intracranial >6 months group, 5/6 pigs in the oral <6 months group, and 4/6 oral >6 months group. Overall, the MLN was positive in 14/19 (74%) of samples examined, the RPLN in [U]8/18[/U] (44%), and the tonsil in 10/25 (40%). ***> Conclusions: This study demonstrates that PrPSc accumulates in lymphoid tissues from pigs challenged intracranially or orally with the CWD agent, and can be detected as early as 4 months after challenge. CWD-infected pigs rarely develop clinical disease and if they do, they do so after a long incubation period. This raises the possibility that CWD-infected pigs could shed prions into their environment long before they develop clinical disease. Furthermore, lymphoid tissues from CWD-infected pigs could present a potential source of CWD infectivity in the animal and human food chains. [U][URL]https://www.ars.usda.gov/research/publications/publication/?seqNo115=353091[/URL] [URL]https://www.ars.usda.gov/research/project/?accnNo=432011&fy=2017[/URL] [URL]https://www.ars.usda.gov/research/publications/publication/?seqNo115=337105[/URL][/U] Conclusions: This study demonstrates that PrPSc accumulates in lymphoid tissues from pigs challenged intracranially or orally with the CWD agent, and can be detected as early as 4 months after challenge. CWD-infected pigs rarely develop clinical disease and if they do, they do so after a long incubation period. This raises the possibility that CWD-infected pigs could shed prions into their environment long before they develop clinical disease. Furthermore, lymphoid tissues from CWD-infected pigs could present a potential source of CWD infectivity in the animal and human food chains. [U][URL]https://www.ars.usda.gov/research/publications/publication/?seqNo115=337105[/URL][/U] THIS MUST CHANGE ASAP! "For elk and deer considered at high risk for CWD, the FDA recommends that these animals do not enter the animal feed system. However, this recommendation is guidance and not a requirement by law."… Snip… please see my full submission with reference materials… 300NG is enough to transmit cwd to deer by oral route! Monday, November 13, 2023 Food and Drug Administration's BSE Feed Regulation (21 CFR [U]589.2000[/U]) Singeltary Another Request for Update 2023 [U][URL='https://fdabse589.blogspot.com/2023/11/food-and-drug-administrations-bse-feed.html']https://fdabse589.blogspot.com/2023/11/food-and-drug-administrations-bse-feed.htm[/URL][/U] THIS MUST CHANGE ASAP! "For elk and deer considered at high risk for CWD, the FDA recommends that these animals do not enter the animal feed system. However, this recommendation is guidance and not a requirement by law."… Snip… please see my full submission with reference materials… 300NG is enough to transmit cwd to deer by oral route! Monday, November 13, 2023 Food and Drug Administration's BSE Feed Regulation (21 CFR [U]589.2000[/U]) Singeltary Another Request for Update 2023 [U][URL='https://fdabse589.blogspot.com/2023/11/food-and-drug-administrations-bse-feed.html']https://fdabse589.blogspot.com/2023/11/food-and-drug-administrations-bse-feed.htm[/URL] terry[/U] [/QUOTE]
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