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<blockquote data-quote="flounder" data-source="post: 1841718" data-attributes="member: 3519"><p>Wednesday, May 24, 2023</p><p></p><p>***> WAHIS, WOAH, OIE, United States of America Bovine spongiform encephalopathy Immediate notification</p><p></p><p><a href="https://wahis.woah.org/#/in-review/5067" target="_blank">https://wahis.woah.org/#/in-review/5067</a></p><p></p><p><a href="https://woahoie.blogspot.com/2023/05/wahis-woah-oie-united-states-of-america.html" target="_blank">https://woahoie.blogspot.com/2023/05/wahis-woah-oie-united-states-of-america.html</a></p><p></p><p><a href="https://prpsc.proboards.com/thread/125/wahis-woah-oie-immediate-notification" target="_blank">https://prpsc.proboards.com/thread/125/wahis-woah-oie-immediate-notification</a></p><p></p><p>MAY 19, 2023</p><p></p><p><a href="https://www.aphis.usda.gov/aphis/newsroom/stakeholder-info/sa_by_date/sa-2023/bse" target="_blank">https://www.aphis.usda.gov/aphis/newsroom/stakeholder-info/sa_by_date/sa-2023/bse</a></p><p></p><p>***> APPRX. 2 weeks before the recent mad cow case was confirmed in the USA, in Tennessee, atypical L-Type BSE, I submitted this to the APHIS et al;</p><p></p><p>Document APHIS-2023-0027-0001 BSE Singeltary Comment Submission May 2, 2023</p><p></p><p>''said 'burden' cost, will be a heavy burden to bear, if we fail with Bovine Spongiform Encephalopathy BSE TSE Prion disease, that is why this information collection is so critical''...</p><p></p><p><a href="https://www.regulations.gov/comment/APHIS-2023-0027-0002" target="_blank">https://www.regulations.gov/comment/APHIS-2023-0027-0002</a></p><p></p><p><a href="https://downloads.regulations.gov/APHIS-2023-0027-0002/attachment_1.pdf" target="_blank">https://downloads.regulations.gov/APHIS-2023-0027-0002/attachment_1.pdf</a></p><p></p><p>outbreak of spontaneous mad cow disease evidently, around the same time, strange;</p><p></p><p>WEDNESDAY, NOVEMBER 08, 2023</p><p></p><p>Ireland Atypical BSE confirmed November 3 2023</p><p></p><p><a href="https://bse-atypical.blogspot.com/2023/11/ireland-atypical-bse-confirmed-november.html" target="_blank">https://bse-atypical.blogspot.com/2023/11/ireland-atypical-bse-confirmed-november.html</a></p><p></p><p>TUESDAY, NOVEMBER 14, 2023</p><p></p><p>Ireland Atypical BSE case, 3 progeny of case cow to be culled</p><p></p><p><a href="https://bse-atypical.blogspot.com/2023/11/ireland-atypical-bse-case-3-progeny-of.html" target="_blank">https://bse-atypical.blogspot.com/2023/11/ireland-atypical-bse-case-3-progeny-of.html</a></p><p></p><p>SUNDAY, JULY 16, 2023</p><p></p><p>Switzerland Atypical BSE detected in a cow in the canton of St. Gallen</p><p></p><p><a href="https://bse-atypical.blogspot.com/2023/07/switzerland-atypical-bse-detected-in.html" target="_blank">https://bse-atypical.blogspot.com/2023/07/switzerland-atypical-bse-detected-in.html</a></p><p></p><p>WAHIS, WOAH, OIE, REPORT Switzerland Bovine Spongiform Encephalopathy Atypical L-Type</p><p></p><p><a href="https://wahis.woah.org/#/in-review/4962" target="_blank">https://wahis.woah.org/#/in-review/4962</a></p><p></p><p><a href="https://bse-atypical.blogspot.com/2020/02/switzerland-oie-bovine-spongiform.html" target="_blank">https://bse-atypical.blogspot.com/2020/02/switzerland-oie-bovine-spongiform.html</a></p><p></p><p>Monday, March 20, 2023</p><p></p><p>WAHIS, WOAH, OIE, REPORT United Kingdom Bovine Spongiform Encephalopathy Atypical H-Type</p><p></p><p><a href="https://wahis.woah.org/#/in-review/4977" target="_blank">https://wahis.woah.org/#/in-review/4977</a></p><p></p><p><a href="https://www.gov.uk/government/news/single-case-of-atypical-bse-confirmed-on-a-farm-in-cornwall" target="_blank">https://www.gov.uk/government/news/single-case-of-atypical-bse-confirmed-on-a-farm-in-cornwall</a></p><p></p><p><a href="https://woahoie.blogspot.com/2023/03/wahis-woah-oie-report-united-kingdom.html" target="_blank">https://woahoie.blogspot.com/2023/03/wahis-woah-oie-report-united-kingdom.html</a></p><p></p><p>BRAZIL BSE CONFIRMATION DATE 2023/02/2</p><p></p><p><a href="https://wahis.woah.org/#/in-review/4918" target="_blank">https://wahis.woah.org/#/in-review/4918</a></p><p></p><p><a href="https://bse-atypical.blogspot.com/2019/06/brazil-reports-another-cases-of-mad-cow.html" target="_blank">https://bse-atypical.blogspot.com/2019/06/brazil-reports-another-cases-of-mad-cow.html</a></p><p></p><p>SPAIN BSE CONFIRMATION DATE 2023/02/03</p><p></p><p><a href="https://wahis.woah.org/#/in-review/4888" target="_blank">https://wahis.woah.org/#/in-review/4888</a></p><p></p><p><a href="https://bse-atypical.blogspot.com/2023/02/spain-bovine-spongiform-encephalopathy.html" target="_blank">https://bse-atypical.blogspot.com/2023/02/spain-bovine-spongiform-encephalopathy.html</a></p><p></p><p>NETHERLANDS BSE CONFIRMATION DATE 2023/02/01</p><p></p><p><a href="https://wahis.woah.org/#/in-review/4876" target="_blank">https://wahis.woah.org/#/in-review/4876</a></p><p></p><p><a href="https://bse-atypical.blogspot.com/2023/02/netherlands-bovine-spongiform.html" target="_blank">https://bse-atypical.blogspot.com/2023/02/netherlands-bovine-spongiform.html</a></p><p></p><p>PLEASE NOTE, USDA ET AL ONLY TESTING <25k CATTLE FOR MAD COW DISEASE, woefully inadequate, yet USDA just documented a case Atypical L-Type BSE, the most virulent strain to date...</p><p></p><p>Monday, May 22, 2023 </p><p></p><p>***> BSE TSE Prion MAD COW TESTING IN THE USA COMPARED TO OTHER COUNTRIES? </p><p></p><p><a href="https://specifiedriskmaterial.blogspot.com/2023/05/bse-tse-prion-mad-cow-testing-in-usa.html" target="_blank">https://specifiedriskmaterial.blogspot.com/2023/05/bse-tse-prion-mad-cow-testing-in-usa.html</a></p><p></p><p></p><p></p><p></p><p>***> Results: PrPSc was not detected by EIA and IHC in any RPLNs. All tonsils and MLNs were negative by IHC, though the MLN from one pig in the oral <6 month group was positive by EIA. PrPSc was detected by QuIC in at least one of the lymphoid tissues examined in 5/6 pigs in the intracranial <6 months group, 6/7 intracranial >6 months group, 5/6 pigs in the oral <6 months group, and 4/6 oral >6 months group. Overall, the MLN was positive in 14/19 (74%) of samples examined, the RPLN in 8/18 (44%), and the tonsil in 10/25 (40%). </p><p></p><p>***> Conclusions: This study demonstrates that PrPSc accumulates in lymphoid tissues from pigs challenged intracranially or orally with the CWD agent, and can be detected as early as 4 months after challenge. CWD-infected pigs rarely develop clinical disease and if they do, they do so after a long incubation period. This raises the possibility that CWD-infected pigs could shed prions into their environment long before they develop clinical disease. Furthermore, lymphoid tissues from CWD-infected pigs could present a potential source of CWD infectivity in the animal and human food chains. </p><p></p><p>[URL unfurl="true"]https://www.ars.usda.gov/research/publications/publication/?seqNo115=353091[/URL]</p><p></p><p>[URL unfurl="true"]https://www.ars.usda.gov/research/project/?accnNo=432011&fy=2017[/URL]</p><p></p><p>[URL unfurl="true"]https://www.ars.usda.gov/research/publications/publication/?seqNo115=337105[/URL]</p><p></p><p></p><p>kind regards, terry</p></blockquote><p></p>
[QUOTE="flounder, post: 1841718, member: 3519"] Wednesday, May 24, 2023 ***> WAHIS, WOAH, OIE, United States of America Bovine spongiform encephalopathy Immediate notification [URL]https://wahis.woah.org/#/in-review/5067[/URL] [URL]https://woahoie.blogspot.com/2023/05/wahis-woah-oie-united-states-of-america.html[/URL] [URL]https://prpsc.proboards.com/thread/125/wahis-woah-oie-immediate-notification[/URL] MAY 19, 2023 [URL]https://www.aphis.usda.gov/aphis/newsroom/stakeholder-info/sa_by_date/sa-2023/bse[/URL] ***> APPRX. 2 weeks before the recent mad cow case was confirmed in the USA, in Tennessee, atypical L-Type BSE, I submitted this to the APHIS et al; Document APHIS-2023-0027-0001 BSE Singeltary Comment Submission May 2, 2023 ''said 'burden' cost, will be a heavy burden to bear, if we fail with Bovine Spongiform Encephalopathy BSE TSE Prion disease, that is why this information collection is so critical''... [URL]https://www.regulations.gov/comment/APHIS-2023-0027-0002[/URL] [URL]https://downloads.regulations.gov/APHIS-2023-0027-0002/attachment_1.pdf[/URL] outbreak of spontaneous mad cow disease evidently, around the same time, strange; WEDNESDAY, NOVEMBER 08, 2023 Ireland Atypical BSE confirmed November 3 2023 [URL]https://bse-atypical.blogspot.com/2023/11/ireland-atypical-bse-confirmed-november.html[/URL] TUESDAY, NOVEMBER 14, 2023 Ireland Atypical BSE case, 3 progeny of case cow to be culled [URL]https://bse-atypical.blogspot.com/2023/11/ireland-atypical-bse-case-3-progeny-of.html[/URL] SUNDAY, JULY 16, 2023 Switzerland Atypical BSE detected in a cow in the canton of St. Gallen [URL]https://bse-atypical.blogspot.com/2023/07/switzerland-atypical-bse-detected-in.html[/URL] WAHIS, WOAH, OIE, REPORT Switzerland Bovine Spongiform Encephalopathy Atypical L-Type [URL]https://wahis.woah.org/#/in-review/4962[/URL] [URL]https://bse-atypical.blogspot.com/2020/02/switzerland-oie-bovine-spongiform.html[/URL] Monday, March 20, 2023 WAHIS, WOAH, OIE, REPORT United Kingdom Bovine Spongiform Encephalopathy Atypical H-Type [URL]https://wahis.woah.org/#/in-review/4977[/URL] [URL]https://www.gov.uk/government/news/single-case-of-atypical-bse-confirmed-on-a-farm-in-cornwall[/URL] [URL]https://woahoie.blogspot.com/2023/03/wahis-woah-oie-report-united-kingdom.html[/URL] BRAZIL BSE CONFIRMATION DATE 2023/02/2 [URL]https://wahis.woah.org/#/in-review/4918[/URL] [URL]https://bse-atypical.blogspot.com/2019/06/brazil-reports-another-cases-of-mad-cow.html[/URL] SPAIN BSE CONFIRMATION DATE 2023/02/03 [URL]https://wahis.woah.org/#/in-review/4888[/URL] [URL]https://bse-atypical.blogspot.com/2023/02/spain-bovine-spongiform-encephalopathy.html[/URL] NETHERLANDS BSE CONFIRMATION DATE 2023/02/01 [URL]https://wahis.woah.org/#/in-review/4876[/URL] [URL]https://bse-atypical.blogspot.com/2023/02/netherlands-bovine-spongiform.html[/URL] PLEASE NOTE, USDA ET AL ONLY TESTING <25k CATTLE FOR MAD COW DISEASE, woefully inadequate, yet USDA just documented a case Atypical L-Type BSE, the most virulent strain to date... Monday, May 22, 2023 ***> BSE TSE Prion MAD COW TESTING IN THE USA COMPARED TO OTHER COUNTRIES? [URL]https://specifiedriskmaterial.blogspot.com/2023/05/bse-tse-prion-mad-cow-testing-in-usa.html[/URL] ***> Results: PrPSc was not detected by EIA and IHC in any RPLNs. All tonsils and MLNs were negative by IHC, though the MLN from one pig in the oral <6 month group was positive by EIA. PrPSc was detected by QuIC in at least one of the lymphoid tissues examined in 5/6 pigs in the intracranial <6 months group, 6/7 intracranial >6 months group, 5/6 pigs in the oral <6 months group, and 4/6 oral >6 months group. Overall, the MLN was positive in 14/19 (74%) of samples examined, the RPLN in 8/18 (44%), and the tonsil in 10/25 (40%). ***> Conclusions: This study demonstrates that PrPSc accumulates in lymphoid tissues from pigs challenged intracranially or orally with the CWD agent, and can be detected as early as 4 months after challenge. CWD-infected pigs rarely develop clinical disease and if they do, they do so after a long incubation period. This raises the possibility that CWD-infected pigs could shed prions into their environment long before they develop clinical disease. Furthermore, lymphoid tissues from CWD-infected pigs could present a potential source of CWD infectivity in the animal and human food chains. [URL unfurl="true"]https://www.ars.usda.gov/research/publications/publication/?seqNo115=353091[/URL] [URL unfurl="true"]https://www.ars.usda.gov/research/project/?accnNo=432011&fy=2017[/URL] [URL unfurl="true"]https://www.ars.usda.gov/research/publications/publication/?seqNo115=337105[/URL] kind regards, terry [/QUOTE]
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