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Hoof Rot time frame
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<blockquote data-quote="Lucky_P" data-source="post: 1169046" data-attributes="member: 12607"><p>KB is correct about tetracycline and penicillin working at cross-purposes with one another. This is true for many - but not all - combos of bacteriCIDAL and bacterioSTATIC antimicrobials . In most instances, bactericidal drugs require the organisms to be actively growing for them to exert their effects - but if you're concurrently administering a bacteriostatic drug, that stops or slows their growth...the 'cidal drug is ineffective. </p><p></p><p>I always had good luck treating footrot with a combination of LA-200 and appropriate dose of long-acting sulfa-drug boluses; one treatment was all that was usually needed. </p><p></p><p>If anyone has 'cured' anything with the 'long-acting' penicillin product, that animal probably would have survived and recovered even without it. The procaine penicillin G fraction is gone in 12 hours - and is underdosed, at that, if you give the recommended label dose; the benzathine penicillin G fraction does stay in the bloodstream for up to 48 hours, but it cannot ever achieve high enough blood/tissue levels to be effective. It would likely never get approval if they had to go through the licensing process today...</p></blockquote><p></p>
[QUOTE="Lucky_P, post: 1169046, member: 12607"] KB is correct about tetracycline and penicillin working at cross-purposes with one another. This is true for many - but not all - combos of bacteriCIDAL and bacterioSTATIC antimicrobials . In most instances, bactericidal drugs require the organisms to be actively growing for them to exert their effects - but if you're concurrently administering a bacteriostatic drug, that stops or slows their growth...the 'cidal drug is ineffective. I always had good luck treating footrot with a combination of LA-200 and appropriate dose of long-acting sulfa-drug boluses; one treatment was all that was usually needed. If anyone has 'cured' anything with the 'long-acting' penicillin product, that animal probably would have survived and recovered even without it. The procaine penicillin G fraction is gone in 12 hours - and is underdosed, at that, if you give the recommended label dose; the benzathine penicillin G fraction does stay in the bloodstream for up to 48 hours, but it cannot ever achieve high enough blood/tissue levels to be effective. It would likely never get approval if they had to go through the licensing process today... [/QUOTE]
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