BSE, SCRAPIE, CWD, TSE PRION END OF YEAR REPORTS USA AND CANADA

[flounder]

TUESDAY, DECEMBER 12, 2017

Bovine Spongiform Encephalopathy BSE TSE Prion (aka mad cow disease) Report December 14, 2017 2017

http://bovineprp.blogspot.com/2017/12/b ... y-bse.html

TUESDAY, DECEMBER 12, 2017

Chronic Wasting Disease CWD TSE Prion (aka mad deer disease) Update USA December 14, 2017

(zoonosis and environmental risk factors towards the bottom, after state by state reports)

http://chronic-wasting-disease.blogspot ... prion.html

FRIDAY, DECEMBER 15, 2017

Canada CFIA updating its national CWD TSE PRION efforts to eradicate disease farmed cervid NOT successful December 14, 2017

http://chronic-wasting-disease.blogspot ... l-cwd.html

TUESDAY, DECEMBER 12, 2017

SCRAPIE TSE PRION UPDATE USA DECEMBER 14, 2017

http://scrapie-usa.blogspot.com/2017/12 ... ember.html

TUESDAY, DECEMBER 12, 2017

Creutzfeldt Jakob Disease CJD National Prion Disease Pathology Surveillance Center Cases Examined to December 14, 2017

http://creutzfeldt-jakob-disease.blogsp ... ional.html

Tuesday, December 12, 2017

Neuropathology of iatrogenic Creutzfeldt–Jakob disease and immunoassay of French cadaver-sourced growth hormone batches suggest possible transmission of tauopathy and long incubation periods for the transmission of Abeta pathology

http://tauopathies.blogspot.com/2017/12 ... genic.html

TERRY S. SINGELTARY SR.

 

[Douglas]

why don't you give us a summary of the finding so we don't have to look for hrs. trying to figure out what you expect us to believe, again.

 

[Silver]

why don't you give us a summary of the finding so we don't have to look for hrs. trying to figure out what you expect us to believe, again.

What's the point? It's fake science.

 

[flounder]

Detection of PrPBSE and prion infectivity in the ileal Peyer's patch of young calves as early as 2 months after oral challenge with classical bovine spongiform encephalopathy

Ivett Ackermann, Anne Balkema-Buschmann, Reiner Ulrich, Kerstin Tauscher, James C. Shawulu, Markus Keller, Olanrewaju I. Fatola, Paul Brown and Martin H. GroschupEmail authorView ORCID ID profile

Veterinary Research201748:88

https://doi.org/10.1186/s13567-017-0495-5© The Author(s) 2017

Received: 22 August 2017Accepted: 1 December 2017Published: 19 December 2017

Abstract

In classical bovine spongiform encephalopathy (C-BSE), an orally acquired prion disease of cattle, the ileal Peyer's patch (IPP) represents the main entry port for the BSE agent. In earlier C-BSE pathogenesis studies, cattle at 4–6 months of age were orally challenged, while there are strong indications that the risk of infection is highest in young animals. In the present study, unweaned calves aged 4–6 weeks were orally challenged to determine the earliest time point at which newly formed PrPBSE and BSE infectivity are detectable in the IPP. For this purpose, calves were culled 1 week as well as 2, 4, 6 and 8 months post-infection (mpi) and IPPs were examined for BSE infectivity using a bovine PrP transgenic mouse bioassay, and for PrPBSE by immunohistochemistry (IHC) and protein misfolding cyclic amplification (PMCA) assays. For the first time, BSE prions were detected in the IPP as early as 2 mpi by transgenic mouse bioassay and PMCA and 4 mpi by IHC in the follicular dendritic cells (FDCs) of the IPP follicles. These data indicate that BSE prions propagate in the IPP of unweaned calves within 2 months of oral uptake of the agent.

snip...

In summary, our study demonstrates for the first time PrPBSE (by PMCA) and prion infectivity (by mouse bioassay) in the ileal Peyer's patch (IPP) of young calves as early as 2 months after infection. From 4 mpi nearly all calves showed PrPBSE positive IPP follicles (by IHC), even with PrPBSE accumulation detectable in FDCs in some animals. Finally, our results confirm the IPP as the early port of entry for the BSE agent and a site of initial propagation of PrPBSE and infectivity during the early pathogenesis of the disease. Therefore, our study supports the recommendation to remove the last four metres of the small intestine (distal ileum) at slaughter, as designated by current legal requirements for countries with a controlled BSE risk status, as an essential measure for consumer and public health protection.

https://veterinaryresearch.biomedcentra ... 017-0495-5

Thursday, November 16, 2017

Texas Natural Meats Recalls Beef Products Due To Possible Specified Risk Materials Contamination

http://specifiedriskmaterial.blogspot.c ... -beef.html

FRIDAY, DECEMBER 22, 2017

Detection of PrPBSE and prion infectivity in the ileal Peyer's patch of young calves as early as 2 months after oral challenge with classical bovine spongiform encephalopathy

http://bovineprp.blogspot.com/2017/12/d ... prion.html