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Angus Genetic Condition Update
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<blockquote data-quote="Lucky_P" data-source="post: 1046172" data-attributes="member: 12607"><p>All indications are - and based on similar condition(duplication/polymelia) that's been extensively studied in mice - that homozygotes - embryos inheriting a copy of the defective gene from both parents - experience a very high incidence of early embryonic death. It's likely that somewhere in the neighborhood of only 1-5% of those make it to term; the rest are aborted early on.</p><p>That may explain why some herds which have stacked carriers in their breeding program have experienced higher-than-expected incidence of 'open' cows or apparent conceptionfailures - and, in some cases, why investigations into potential causes of 'infertility' have come up with nada. By that token, a number of those carrier cows may have removed themselves from the genepool, just by virtue of coming up open.</p><p></p><p>Carrier animals will be phenotypically normal in all respects. Homozygotes surviving to term will be few and far between. Hard to imagine someone keeping a bull - or heifer, for that matter - with one or more extra legs as a breeding animal.</p><p></p><p>So far, I've dodged the bullet on this defect, as well as AM,NH, and CAC(this one came closest here!) - but I'd sure considered using several of the Angus sires that have come up as DDC; just hadn't pulled the trigger. </p><p>Pretty sure Ken Caryl Mr Angus is in the pedigree way back behind some of the Angus genetics in my herd, but all ancestors close up are DDF. Haven't looked extensively, but don't know that any on the carrier list are back in behind any of my Simmental-influenced cows.</p><p>Neighbors next door have a number of Predestined & 5050 heifers/cows - I've advised them to be careful what they breed 'em to - definitely not Pred or 5050.</p></blockquote><p></p>
[QUOTE="Lucky_P, post: 1046172, member: 12607"] All indications are - and based on similar condition(duplication/polymelia) that's been extensively studied in mice - that homozygotes - embryos inheriting a copy of the defective gene from both parents - experience a very high incidence of early embryonic death. It's likely that somewhere in the neighborhood of only 1-5% of those make it to term; the rest are aborted early on. That may explain why some herds which have stacked carriers in their breeding program have experienced higher-than-expected incidence of 'open' cows or apparent conceptionfailures - and, in some cases, why investigations into potential causes of 'infertility' have come up with nada. By that token, a number of those carrier cows may have removed themselves from the genepool, just by virtue of coming up open. Carrier animals will be phenotypically normal in all respects. Homozygotes surviving to term will be few and far between. Hard to imagine someone keeping a bull - or heifer, for that matter - with one or more extra legs as a breeding animal. So far, I've dodged the bullet on this defect, as well as AM,NH, and CAC(this one came closest here!) - but I'd sure considered using several of the Angus sires that have come up as DDC; just hadn't pulled the trigger. Pretty sure Ken Caryl Mr Angus is in the pedigree way back behind some of the Angus genetics in my herd, but all ancestors close up are DDF. Haven't looked extensively, but don't know that any on the carrier list are back in behind any of my Simmental-influenced cows. Neighbors next door have a number of Predestined & 5050 heifers/cows - I've advised them to be careful what they breed 'em to - definitely not Pred or 5050. [/QUOTE]
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