I had a commercial building for awhile, and I rented it to a guy that bought and sold vehicles for a living. And he acquired whatever he sold, cars, trucks, ATV and side by side, and lots of motorcycles from San Diego, Louisiana, Texas, and Denver, all at least 500 miles from his rental building.
He had the longest bumper hitch, triple axle, enclosed trailer I've ever seen.
He pulled it with a Doge diesel for awhile, and then he bought a "totaled" Ford Super Duty diesel. And he had some kind of special setup on the Dodge, and then he transferred it to the Ford because he got phenomenal milage. He had a propane tank... and something that provided water injection. He claimed to get over 30 mpg... towing a loaded trailer.
Now I never took any trips with him, but I never got the feeling he was lying. Take it for what it's worth.