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Stop Using Modified Live Vaccines-------Abort
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<blockquote data-quote="Lucky_P" data-source="post: 967974" data-attributes="member: 12607"><p>inyati, </p><p>The MLV rota/corona vaccines should pose no threat - but I will recommend that you consider giving them perhaps a bit earlier - recent studies have shown that colostral antibody levels are pretty well 'set' at their maximum level by 5 weeks pre-calving - so, anything that you're trying to do, in the way of boosting colostral antibodies - needs to be done well in advance of that 5-week 'cutoff' date. </p><p>I'd have some concern that a CalfGuard vaccination 6 weeks out will not provide sufficient time for IgA production, at least as far as colostral antibodies are concerned; however, let me backtrack for a moment and reassess the situation: absorbed colostral antibodies don't provide significant protection against rota/coronaviruses - you need 'local' IgA, present in the gut lumen to tie those up, and 6 weeks pre-calving should be plenty of time to get that udder's immune system primed to be producing those antibodies to act as 'antiseptic paint' to protect the calf during the first 30 days or so of the postpartum period. Studies even as far back as the late 1980s showed that vaccinated heifers were still passing detectable anti-coronavirus antibodies in their milk 30 days post-calving. </p><p>Carry on...</p></blockquote><p></p>
[QUOTE="Lucky_P, post: 967974, member: 12607"] inyati, The MLV rota/corona vaccines should pose no threat - but I will recommend that you consider giving them perhaps a bit earlier - recent studies have shown that colostral antibody levels are pretty well 'set' at their maximum level by 5 weeks pre-calving - so, anything that you're trying to do, in the way of boosting colostral antibodies - needs to be done well in advance of that 5-week 'cutoff' date. I'd have some concern that a CalfGuard vaccination 6 weeks out will not provide sufficient time for IgA production, at least as far as colostral antibodies are concerned; however, let me backtrack for a moment and reassess the situation: absorbed colostral antibodies don't provide significant protection against rota/coronaviruses - you need 'local' IgA, present in the gut lumen to tie those up, and 6 weeks pre-calving should be plenty of time to get that udder's immune system primed to be producing those antibodies to act as 'antiseptic paint' to protect the calf during the first 30 days or so of the postpartum period. Studies even as far back as the late 1980s showed that vaccinated heifers were still passing detectable anti-coronavirus antibodies in their milk 30 days post-calving. Carry on... [/QUOTE]
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