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<blockquote data-quote="Lucky_P" data-source="post: 756391" data-attributes="member: 12607"><p>angus9259,</p><p>Well, it looks like I shot my mouth off without doing a thorough review of the <u>current </u>literature. Sometimes old 'knowledge' is faulty knowledge. My apologies...</p><p>There's a decent short discussion of seminal vesiculitis about 3/4 of the way down this page from the Society for Theriogenology: <a href="http://www.vetmed.lsu.edu/eiltslotus/theriogenology-5361/bull.htm" target="_blank">http://www.vetmed.lsu.edu/eiltslotus/th ... 1/bull.htm</a></p><p>Should answer most of your questions.</p><p></p><p>I left practice and have been doing diagnostic pathology for the past 20 years, so other than treating my own cattle, and being involved with diagnostic cases and peripheral involvement with cases my wife saw while she was still in active practice, I've not encountered a case of seminal vesiculitis in years, other than seeing 'pus' in semen samples we evaluate here at the lab.</p><p></p><p>How does treatment with LA-100 & sulfas compare to PPG? I dunno. It would still be my choice, though, just based on previous performance. </p><p></p><p>Most producers - and many veterinarians - misuse penicillin. Appropriate dosage, regardless of what may be stated on the bottle, of procaine penicillin G( PPG, 300,000 IU/ml) is 3ml/100 lb body weight twice daily. Less than that is underdosing, and a single injection only provides about 12 hours of therapeutic blood levels, hence the need to give it twice daily. When I used it, we'd go for at least 3-5 days, and evaluate progress at that time; if no response, we'd switch to something else.</p><p> </p><p>The 'long-acting'/48 hour penicillin stuff - is garbage. Yeah, it stays in their system for 48 hours, but the 'long-acting' portion, the benzathine penicillin G, never reaches a blood/tissue level high enough to do anything, and if you give it at the label dosage of 2ml/150 lb, you're not getting enough PPG in the animal to get the blood levels of the drug up to therapeutic levels, and even then, it drops off drastically after 12 hrs. This stuff got FDA approval back in the Dark Ages, I presume before anyone was doing pharmacokinetic studies; I don't think it would pass muster if they had to go through the approval process today.</p></blockquote><p></p>
[QUOTE="Lucky_P, post: 756391, member: 12607"] angus9259, Well, it looks like I shot my mouth off without doing a thorough review of the [u]current [/u]literature. Sometimes old 'knowledge' is faulty knowledge. My apologies... There's a decent short discussion of seminal vesiculitis about 3/4 of the way down this page from the Society for Theriogenology: [url=http://www.vetmed.lsu.edu/eiltslotus/theriogenology-5361/bull.htm]http://www.vetmed.lsu.edu/eiltslotus/th ... 1/bull.htm[/url] Should answer most of your questions. I left practice and have been doing diagnostic pathology for the past 20 years, so other than treating my own cattle, and being involved with diagnostic cases and peripheral involvement with cases my wife saw while she was still in active practice, I've not encountered a case of seminal vesiculitis in years, other than seeing 'pus' in semen samples we evaluate here at the lab. How does treatment with LA-100 & sulfas compare to PPG? I dunno. It would still be my choice, though, just based on previous performance. Most producers - and many veterinarians - misuse penicillin. Appropriate dosage, regardless of what may be stated on the bottle, of procaine penicillin G( PPG, 300,000 IU/ml) is 3ml/100 lb body weight twice daily. Less than that is underdosing, and a single injection only provides about 12 hours of therapeutic blood levels, hence the need to give it twice daily. When I used it, we'd go for at least 3-5 days, and evaluate progress at that time; if no response, we'd switch to something else. The 'long-acting'/48 hour penicillin stuff - is garbage. Yeah, it stays in their system for 48 hours, but the 'long-acting' portion, the benzathine penicillin G, never reaches a blood/tissue level high enough to do anything, and if you give it at the label dosage of 2ml/150 lb, you're not getting enough PPG in the animal to get the blood levels of the drug up to therapeutic levels, and even then, it drops off drastically after 12 hrs. This stuff got FDA approval back in the Dark Ages, I presume before anyone was doing pharmacokinetic studies; I don't think it would pass muster if they had to go through the approval process today. [/QUOTE]
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