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NCBA, R-CALF, COOL, USDA (No Politics!)
OIE WAHIS SPAIN BOVINE SPONGIFORM ENCEPHALOPATHY BSE Atypical H-Type
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<blockquote data-quote="flounder" data-source="post: 1788088" data-attributes="member: 3519"><p>OIE WAHIS SPAIN BOVINE SPONGIFORM ENCEPHALOPATHY BSE Atypical H-Type</p><p></p><p>Spain - Bovine spongiform encephalopathy - Immediate notification</p><p></p><p>GENERAL INFORMATION</p><p></p><p>COUNTRY/TERRITORY OR ZONE</p><p></p><p>ZONE</p><p></p><p>ANIMAL TYPE</p><p></p><p>TERRESTRIAL</p><p></p><p>DISEASE CATEGORY</p><p></p><p>OIE-listed</p><p></p><p>EVENT ID</p><p></p><p>4888</p><p></p><p>DISEASE</p><p></p><p>Bovine spongiform encephalopathy</p><p></p><p>CAUSAL AGENT</p><p></p><p>Bovine spongiform encephalopathy prion, atypical strain, H-type</p><p></p><p>GENOTYPE / SEROTYPE / SUBTYPE</p><p></p><p>START DATE</p><p></p><p>2023/01/21</p><p></p><p>REASON FOR NOTIFICATION</p><p></p><p>Recurrence of an eradicated disease</p><p></p><p>DATE OF LAST OCCURRENCE</p><p></p><p>2021/04/16</p><p></p><p>CONFIRMATION DATE</p><p></p><p>2023/02/03</p><p></p><p>EVENT STATUS</p><p></p><p>Resolved</p><p></p><p>END DATE</p><p></p><p>2023/02/06</p><p></p><p>SELF-DECLARATION</p><p></p><p>NO</p><p></p><p>REPORT INFORMATION</p><p></p><p>REPORT NUMBER</p><p></p><p>Immediate notification</p><p></p><p>REPORT ID</p><p></p><p>IN_159183</p><p></p><p>REPORT REFERENCE</p><p></p><p>REPORT DATE</p><p></p><p>2023/02/07</p><p></p><p>REPORT STATUS</p><p></p><p>Validated</p><p></p><p>NO EVOLUTION REPORT</p><p></p><p>EPIDEMIOLOGY</p><p></p><p>SOURCE OF EVENT OR ORIGIN OF INFECTION</p><p></p><p>Unknown or inconclusive</p><p></p><p>EPIDEMIOLOGICAL COMMENTS</p><p></p><p>Point 1 of paragraph 2, Chapter B (Measures following confirmation of a TSE in cattle) of ANNEX VII - CONTROL AND ERADICATION OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES of Regulation (EC) 999/2001 establishes that in case of confirmation of BSE in a bovine animal, all cattle identified in the following cases must be killed and completely destroyed: - in cases where the disease has been confirmed in a female, all her offspring born within two years before or after the clinical onset of the disease, - all animals in the age group of the animal in which the disease has been confirmed, - other animals present on the holding of the animal in which the disease was confirmed, or on other holdings, which may have been infected by the TSE agent or exposed to the same feed or source of contamination. Based on investigations of the two cattle identified on the case farm, they are NOT: - descendants of the affected animal, - cattle that, during their first year of life, were raised with the case so that in their first year of life they have not consumed the same feed, - cattle born during the twelve months before or after the birth of the affected animal, - nor have had access to the same feed while on the farm. So that their slaughter is not considered necessary. However, and as required by European legislation, they were identified for epidemiological investigation as in all cases of BSE.</p><p></p><p>QUANTITATIVE DATA SUMMARY</p><p></p><p>MEASURING UNIT</p><p></p><p>Animal</p><p></p><p>Species Susceptible Cases Deaths Killed and Disposed of Slaughtered/ Killed for commercial use Vaccinated Cattle (DOMESTIC)NEW11-1--TOTAL11-1--</p><p></p><p>DIAGNOSTIC DETAILS</p><p></p><p>CLINICAL SIGNS</p><p></p><p>NO</p><p></p><p>METHOD OF DIAGNOSTIC</p><p></p><p>Diagnostic test</p><p></p><p>Test name Laboratory Species sampled Outbreaks Result date Result</p><p></p><p>Antigen detection Western blot (Ag Western blot) Laboratorio Central de Veterinaria de Algete Cattle Pontevedra 2023/02/03 Positive</p><p></p><p>Immunohistochemistry (IHC) Laboratorio Central de Veterinaria de Algete Cattle Pontevedra 2023/02/03 Positive</p><p></p><p>CONTROL MEASURES AT EVENT LEVEL</p><p></p><p><strong>CONTROL MEASURES AT EVENT LEVEL</strong></p><div style="text-align: center"></div> <div style="text-align: center"></div> <div style="text-align: center"></div> <div style="text-align: center"></div> <div style="text-align: center"><strong>DOMESTIC ANIMALS</strong></div> <div style="text-align: center"><strong></strong></div> <div style="text-align: center"><strong></strong></div> <div style="text-align: center"><strong></strong></div> <div style="text-align: center"><strong></strong></div> <div style="text-align: center"><strong></strong></div> <div style="text-align: center"><strong>WILD ANIMALS</strong></div><p></p><p>Traceability</p><div style="text-align: center"></div> <div style="text-align: center"></div> <div style="text-align: center">Applied</div><p></p><p>Official disposal of carcasses, by-products and waste</p><div style="text-align: center"></div> <div style="text-align: center"></div> <div style="text-align: center">Applied</div><p></p><p><a href="https://wahis.woah.org/#/in-review/4888" target="_blank">https://wahis.woah.org/#/in-review/4888</a></p><p></p><p>Conclusions on transmissibility of atypical BSE among cattle</p><p></p><p>Given that cattle have been successfully infected by the oral route, at least for L-BSE, it is reasonable to conclude that atypical BSE is potentially capable of being recycled in a cattle population if cattle are exposed to contaminated feed. In addition, based on reports of atypical BSE from several countries that have not had C-BSE, it appears likely that atypical BSE would arise as a spontaneous disease in any country, albeit at a very low incidence in old cattle. In the presence of livestock industry practices that would allow it to be recycled in the cattle feed chain, it is likely that some level of exposure and transmission may occur. As a result, since atypical BSE can be reasonably considered to pose a potential background level of risk for any country with cattle, the recycling of both classical and atypical strains in the cattle and broader ruminant populations should be avoided.</p><p></p><p>see full report;</p><p></p><p>REPORT OF THE MEETING OF THE OIE AD HOC GROUP ON BOVINE SPONGIFORM ENCEPHALOPATHY RISK ASSESSMENT AND SURVEILLANCE</p><p></p><p>Paris, 18-21 March 2019</p><p></p><p>snip...</p><p></p><p><a href="https://www.oie.int/fileadmin/SST/adhocreports/Bovine%20spongiform%20encephalopathy/AN/A_AhG_BSEsurv_RiskAss_Mar2019.pdf" target="_blank">https://www.oie.int/fileadmin/SST/adhocreports/Bovine spongiform encephalopathy/AN/A_AhG_BSEsurv_RiskAss_Mar2019.pdf</a></p><p></p><p>***> Consumption of L-BSE–contaminated feed may pose a risk for oral transmission of the disease agent to cattle.</p><p></p><p>***> As a result, since atypical BSE can be reasonably considered to pose a potential background level of risk for any country with cattle, the recycling of both classical and atypical strains in the cattle and broader ruminant populations should be avoided.</p><p></p><p>***> This study demonstrates that the H-type BSE agent is transmissible by the oronasal route.</p><p></p><p>***> These results reinforce the need for ongoing surveillance for classical and atypical BSE to minimize the risk of potentially infectious tissues entering the animal or human food chains.</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324790/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324790/</a></p><p></p><p>Our study clearly confirms, experimentally, the potential risk for interspecies oral transmission of the agent of L-BSE. In our model, this risk appears higher than that for the agent of classical BSE, which could only be transmitted to mouse lemurs after a first passage in macaques (14). We report oral transmission of the L-BSE agent in young and adult primates. Transmission by the IC route has also been reported in young macaques (6,7). A previous study of L-BSE in transgenic mice expressing human PrP suggested an absence of any transmission barrier between cattle and humans for this particular strain of the agent of BSE, in contrast to findings for the agent of classical BSE (9). Thus, it is imperative to maintain measures that prevent the entry of tissues from cattle possibly infected with the agent of L-BSE into the food chain.</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310119/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310119/</a></p><p></p><p>Atypical H-type BSE</p><p></p><p>Research Project: Pathobiology, Genetics, and Detection of Transmissible Spongiform Encephalopathies Location: Virus and Prion Research</p><p></p><p>Title: The agent of H-type bovine spongiform encephalopathy associated with E211K prion protein polymorphism transmits after oronasal challenge</p><p></p><p>Author item Greenlee, Justin item MOORE, S - Orise Fellow item WEST-GREENLEE, M - Iowa State University</p><p></p><p>This study demonstrates that the H-type BSE agent is transmissible by the oronasal route.</p><p></p><p>These results reinforce the need for ongoing surveillance for classical and atypical BSE to minimize the risk of potentially infectious tissues entering the animal or human food chains.</p><p></p><p><a href="https://www.ars.usda.gov/research/publications/publication/?seqNo115=353094" target="_blank">https://www.ars.usda.gov/research/publications/publication/?seqNo115=353094</a></p><p></p><p>Friday, February 10, 2023</p><p></p><p>OIE WAHIS SPAIN BOVINE SPONGIFORM ENCEPHALOPATHY BSE Atypical H-Type</p><p></p><p><a href="https://woahoie.blogspot.com/2023/02/oie-wahis-spain-bovine-spongiform.html" target="_blank">https://woahoie.blogspot.com/2023/02/oie-wahis-spain-bovine-spongiform.html</a></p><p></p><p></p><p>terry</p></blockquote><p></p>
[QUOTE="flounder, post: 1788088, member: 3519"] OIE WAHIS SPAIN BOVINE SPONGIFORM ENCEPHALOPATHY BSE Atypical H-Type Spain - Bovine spongiform encephalopathy - Immediate notification GENERAL INFORMATION COUNTRY/TERRITORY OR ZONE ZONE ANIMAL TYPE TERRESTRIAL DISEASE CATEGORY OIE-listed EVENT ID 4888 DISEASE Bovine spongiform encephalopathy CAUSAL AGENT Bovine spongiform encephalopathy prion, atypical strain, H-type GENOTYPE / SEROTYPE / SUBTYPE START DATE 2023/01/21 REASON FOR NOTIFICATION Recurrence of an eradicated disease DATE OF LAST OCCURRENCE 2021/04/16 CONFIRMATION DATE 2023/02/03 EVENT STATUS Resolved END DATE 2023/02/06 SELF-DECLARATION NO REPORT INFORMATION REPORT NUMBER Immediate notification REPORT ID IN_159183 REPORT REFERENCE REPORT DATE 2023/02/07 REPORT STATUS Validated NO EVOLUTION REPORT EPIDEMIOLOGY SOURCE OF EVENT OR ORIGIN OF INFECTION Unknown or inconclusive EPIDEMIOLOGICAL COMMENTS Point 1 of paragraph 2, Chapter B (Measures following confirmation of a TSE in cattle) of ANNEX VII - CONTROL AND ERADICATION OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES of Regulation (EC) 999/2001 establishes that in case of confirmation of BSE in a bovine animal, all cattle identified in the following cases must be killed and completely destroyed: - in cases where the disease has been confirmed in a female, all her offspring born within two years before or after the clinical onset of the disease, - all animals in the age group of the animal in which the disease has been confirmed, - other animals present on the holding of the animal in which the disease was confirmed, or on other holdings, which may have been infected by the TSE agent or exposed to the same feed or source of contamination. Based on investigations of the two cattle identified on the case farm, they are NOT: - descendants of the affected animal, - cattle that, during their first year of life, were raised with the case so that in their first year of life they have not consumed the same feed, - cattle born during the twelve months before or after the birth of the affected animal, - nor have had access to the same feed while on the farm. So that their slaughter is not considered necessary. However, and as required by European legislation, they were identified for epidemiological investigation as in all cases of BSE. QUANTITATIVE DATA SUMMARY MEASURING UNIT Animal Species Susceptible Cases Deaths Killed and Disposed of Slaughtered/ Killed for commercial use Vaccinated Cattle (DOMESTIC)NEW11-1--TOTAL11-1-- DIAGNOSTIC DETAILS CLINICAL SIGNS NO METHOD OF DIAGNOSTIC Diagnostic test Test name Laboratory Species sampled Outbreaks Result date Result Antigen detection Western blot (Ag Western blot) Laboratorio Central de Veterinaria de Algete Cattle Pontevedra 2023/02/03 Positive Immunohistochemistry (IHC) Laboratorio Central de Veterinaria de Algete Cattle Pontevedra 2023/02/03 Positive CONTROL MEASURES AT EVENT LEVEL [B]CONTROL MEASURES AT EVENT LEVEL[/B] [CENTER] [B]DOMESTIC ANIMALS WILD ANIMALS[/B][/CENTER] Traceability [CENTER] Applied[/CENTER] Official disposal of carcasses, by-products and waste [CENTER] Applied[/CENTER] [URL]https://wahis.woah.org/#/in-review/4888[/URL] Conclusions on transmissibility of atypical BSE among cattle Given that cattle have been successfully infected by the oral route, at least for L-BSE, it is reasonable to conclude that atypical BSE is potentially capable of being recycled in a cattle population if cattle are exposed to contaminated feed. In addition, based on reports of atypical BSE from several countries that have not had C-BSE, it appears likely that atypical BSE would arise as a spontaneous disease in any country, albeit at a very low incidence in old cattle. In the presence of livestock industry practices that would allow it to be recycled in the cattle feed chain, it is likely that some level of exposure and transmission may occur. As a result, since atypical BSE can be reasonably considered to pose a potential background level of risk for any country with cattle, the recycling of both classical and atypical strains in the cattle and broader ruminant populations should be avoided. see full report; REPORT OF THE MEETING OF THE OIE AD HOC GROUP ON BOVINE SPONGIFORM ENCEPHALOPATHY RISK ASSESSMENT AND SURVEILLANCE Paris, 18-21 March 2019 snip... [URL='https://www.oie.int/fileadmin/SST/adhocreports/Bovine%20spongiform%20encephalopathy/AN/A_AhG_BSEsurv_RiskAss_Mar2019.pdf']https://www.oie.int/fileadmin/SST/adhocreports/Bovine spongiform encephalopathy/AN/A_AhG_BSEsurv_RiskAss_Mar2019.pdf[/URL] ***> Consumption of L-BSE–contaminated feed may pose a risk for oral transmission of the disease agent to cattle. ***> As a result, since atypical BSE can be reasonably considered to pose a potential background level of risk for any country with cattle, the recycling of both classical and atypical strains in the cattle and broader ruminant populations should be avoided. ***> This study demonstrates that the H-type BSE agent is transmissible by the oronasal route. ***> These results reinforce the need for ongoing surveillance for classical and atypical BSE to minimize the risk of potentially infectious tissues entering the animal or human food chains. [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324790/[/URL] Our study clearly confirms, experimentally, the potential risk for interspecies oral transmission of the agent of L-BSE. In our model, this risk appears higher than that for the agent of classical BSE, which could only be transmitted to mouse lemurs after a first passage in macaques (14). We report oral transmission of the L-BSE agent in young and adult primates. Transmission by the IC route has also been reported in young macaques (6,7). A previous study of L-BSE in transgenic mice expressing human PrP suggested an absence of any transmission barrier between cattle and humans for this particular strain of the agent of BSE, in contrast to findings for the agent of classical BSE (9). Thus, it is imperative to maintain measures that prevent the entry of tissues from cattle possibly infected with the agent of L-BSE into the food chain. [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310119/[/URL] Atypical H-type BSE Research Project: Pathobiology, Genetics, and Detection of Transmissible Spongiform Encephalopathies Location: Virus and Prion Research Title: The agent of H-type bovine spongiform encephalopathy associated with E211K prion protein polymorphism transmits after oronasal challenge Author item Greenlee, Justin item MOORE, S - Orise Fellow item WEST-GREENLEE, M - Iowa State University This study demonstrates that the H-type BSE agent is transmissible by the oronasal route. These results reinforce the need for ongoing surveillance for classical and atypical BSE to minimize the risk of potentially infectious tissues entering the animal or human food chains. [URL]https://www.ars.usda.gov/research/publications/publication/?seqNo115=353094[/URL] Friday, February 10, 2023 OIE WAHIS SPAIN BOVINE SPONGIFORM ENCEPHALOPATHY BSE Atypical H-Type [URL]https://woahoie.blogspot.com/2023/02/oie-wahis-spain-bovine-spongiform.html[/URL] terry [/QUOTE]
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