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New cattle dewormer
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<blockquote data-quote="Lucky_P" data-source="post: 989755" data-attributes="member: 12607"><p>jabo,</p><p>Before you use it on sheep or goats, a few things to consider(from a noted parasitologist who works with parasite control in small ruminants):</p><p></p><p>1. The safety of the drug has not been tested in any species other than cattle.</p><p>2. The pharmacokinetic profile(how the drug is metabolized in the host) is only known for cattle;this formulation has not been studied in any other species - and could be very different in other species - we don't know if therapeutic blood/tissue levels will even be achieved in goats/sheep, nor how long it will last or how quickly it will dissipate. </p><p>3. Ivermectin resistance is extremely common on some premises, and eprinomectin is in the same class so there will be side resistance. If resistance level is high, the product is unlikely to be effective. If resistance level is low, it will select out the resistant subpopulation, so after 1 or 2 uses you will have a population of highly resistant parasites.</p><p>4. Moxidectin(Cydectin) resistance is becoming very common on goat farms. If the worms are resistant to moxidectin, eprinomectin will not kill them.</p><p>5. Long-term control of parasites (assuming the drug is fairly effective) means that the susceptible parasites on pasture at the time of treatment (refugia) will have a significant amount of natural die off during the activity period of the drug. During that time, only eggs of resistant worms will contaminate the pasture. So after the 120-150 days of control, a large proportion of the infectious larvae on pasture will be from those resistant survivors.</p><p></p><p>I wouldn't recommend it for small ruminants; not sure I'm ready to try it in my cattle.</p></blockquote><p></p>
[QUOTE="Lucky_P, post: 989755, member: 12607"] jabo, Before you use it on sheep or goats, a few things to consider(from a noted parasitologist who works with parasite control in small ruminants): 1. The safety of the drug has not been tested in any species other than cattle. 2. The pharmacokinetic profile(how the drug is metabolized in the host) is only known for cattle;this formulation has not been studied in any other species - and could be very different in other species - we don't know if therapeutic blood/tissue levels will even be achieved in goats/sheep, nor how long it will last or how quickly it will dissipate. 3. Ivermectin resistance is extremely common on some premises, and eprinomectin is in the same class so there will be side resistance. If resistance level is high, the product is unlikely to be effective. If resistance level is low, it will select out the resistant subpopulation, so after 1 or 2 uses you will have a population of highly resistant parasites. 4. Moxidectin(Cydectin) resistance is becoming very common on goat farms. If the worms are resistant to moxidectin, eprinomectin will not kill them. 5. Long-term control of parasites (assuming the drug is fairly effective) means that the susceptible parasites on pasture at the time of treatment (refugia) will have a significant amount of natural die off during the activity period of the drug. During that time, only eggs of resistant worms will contaminate the pasture. So after the 120-150 days of control, a large proportion of the infectious larvae on pasture will be from those resistant survivors. I wouldn't recommend it for small ruminants; not sure I'm ready to try it in my cattle. [/QUOTE]
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