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MAD COW FEED RECALL MI MAMMALIAN PROTEIN 27,694,240 lbs
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<blockquote data-quote="flounder" data-source="post: 255090" data-attributes="member: 3519"><p>Subject: MAD COW FEED RECALL MI MAMMALIAN PROTEIN VOLUME OF PRODUCT IN COMMERCE 27,694,240 lbs</p><p>Date: August 6, 2006 at 6:14 pm PST </p><p>PRODUCT</p><p>Bulk custom dairy feds manufactured from concentrates, Recall # V-113-6</p><p>CODE</p><p>All dairy feeds produced between 2/1/05 and 6/16/06 and containing H. J. Baker recalled feed products.</p><p>RECALLING FIRM/MANUFACTURER</p><p>Vita Plus Corp., Gagetown, MI, by visit beginning on June 21, 2006. Firm initiated recall is complete.</p><p>REASON</p><p>The feed was manufactured from materials that may have been contaminated with mammalian protein.</p><p>VOLUME OF PRODUCT IN COMMERCE</p><p>27,694,240 lbs</p><p>DISTRIBUTION</p><p>MI </p><p></p><p></p><p>END OF ENFORCEMENT REPORT FOR AUGUST 2, 2006 </p><p></p><p>### </p><p></p><p></p><p><a href="http://www.fda.gov/bbs/topics/enforce/2006/ENF00963.html" target="_blank">http://www.fda.gov/bbs/topics/enforce/2 ... 00963.html</a> </p><p></p><p></p><p></p><p>WE know now, and we knew decades ago, that 5.5 grams of suspect feed in TEXAS was enough to kill 100 cows. </p><p></p><p></p><p>look at the table and you'll see that as little as 1 mg (or 0.001 gm) caused 7% (1 of 14) of the cows to come down with BSE; </p><p></p><p></p><p>Risk of oral infection with bovine spongiform encephalopathy agent in primates </p><p></p><p>Corinne Ida Lasmézas, Emmanuel Comoy, Stephen Hawkins, Christian Herzog, Franck Mouthon, Timm Konold, Frédéric Auvré, Evelyne Correia, Nathalie Lescoutra-Etchegaray, Nicole Salès, Gerald Wells, Paul Brown, Jean-Philippe Deslys </p><p>Summary The uncertain extent of human exposure to bovine spongiform encephalopathy (BSE)--which can lead to variant Creutzfeldt-Jakob disease (vCJD)--is compounded by incomplete knowledge about the efficiency of oral infection and the magnitude of any bovine-to-human biological barrier to transmission. We therefore investigated oral transmission of BSE to non-human primates. We gave two macaques a 5 g oral dose of brain homogenate from a BSE-infected cow. One macaque developed vCJD-like neurological disease 60 months after exposure, whereas the other remained free of disease at 76 months. On the basis of these findings and data from other studies, we made a preliminary estimate of the food exposure risk for man, which provides additional assurance that existing public health measures can prevent transmission of BSE to man. </p><p></p><p></p><p>snip... </p><p></p><p></p><p>BSE bovine brain inoculum </p><p></p><p>100 g 10 g 5 g 1 g 100 mg 10 mg 1 mg 0·1 mg 0·01 mg </p><p></p><p>Primate (oral route)* 1/2 (50%) </p><p></p><p>Cattle (oral route)* 10/10 (100%) 7/9 (78%) 7/10 (70%) 3/15 (20%) 1/15 (7%) 1/15 (7%) </p><p></p><p>RIII mice (ic ip route)* 17/18 (94%) 15/17 (88%) 1/14 (7%) </p><p></p><p>PrPres biochemical detection </p><p></p><p>The comparison is made on the basis of calibration of the bovine inoculum used in our study with primates against a bovine brain inoculum with a similar PrPres concentration that was </p><p></p><p>inoculated into mice and cattle.8 *Data are number of animals positive/number of animals surviving at the time of clinical onset of disease in the first positive animal (%). The accuracy of </p><p></p><p>bioassays is generally judged to be about plus or minus 1 log. ic ip=intracerebral and intraperitoneal. </p><p></p><p>Table 1: Comparison of transmission rates in primates and cattle infected orally with similar BSE brain inocula </p><p></p><p></p><p>Published online January 27, 2005 </p><p></p><p><a href="http://www.thelancet.com/journal/journal.isa" target="_blank">http://www.thelancet.com/journal/journal.isa</a> </p><p></p><p></p><p>It is clear that the designing scientists must </p><p></p><p>also have shared Mr Bradley's surprise at the results because all the dose </p><p></p><p>levels right down to 1 gram triggered infection. </p><p></p><p></p><p><a href="http://www.bseinquiry.gov.uk/files/ws/s145d.pdf" target="_blank">http://www.bseinquiry.gov.uk/files/ws/s145d.pdf</a> </p><p></p><p></p><p></p><p>2 </p><p></p><p>6. It also appears to me that Mr Bradley's answer (that it would take less than say 100 </p><p></p><p>grams) was probably given with the benefit of hindsight; particularly if one </p><p></p><p>considers that later in the same answer Mr Bradley expresses his surprise that it </p><p></p><p>could take as little of 1 gram of brain to cause BSE by the oral route within the </p><p></p><p>same species. This information did not become available until the "attack rate" </p><p></p><p>experiment had been completed in 1995/96. This was a titration experiment </p><p></p><p>designed to ascertain the infective dose. A range of dosages was used to ensure </p><p></p><p>that the actual result was within both a lower and an upper limit within the study </p><p></p><p>and the designing scientists would not have expected all the dose levels to trigger </p><p></p><p>infection. The dose ranges chosen by the most informed scientists at that time </p><p></p><p>ranged from 1 gram to three times one hundred grams. It is clear that the designing </p><p></p><p>scientists must have also shared Mr Bradley's surprise at the results because all the </p><p></p><p>dose levels right down to 1 gram triggered infection. </p><p></p><p></p><p><a href="http://www.bseinquiry.gov.uk/files/ws/s147f.pdf" target="_blank">http://www.bseinquiry.gov.uk/files/ws/s147f.pdf</a> </p><p></p><p></p><p></p><p>Re: BSE .1 GRAM LETHAL NEW STUDY SAYS via W.H.O. Dr Maura Ricketts </p><p></p><p>[BBC radio 4 FARM news] </p><p></p><p></p><p><a href="http://www.maddeer.org/audio/BBC4farmingtoday2_1_03.ram" target="_blank">http://www.maddeer.org/audio/BBC4farmingtoday2_1_03.ram</a> </p><p></p><p></p><p></p><p><a href="http://www.fda.gov/ohrms/dockets/ac/03/slides/3923s1_OPH.htm" target="_blank">http://www.fda.gov/ohrms/dockets/ac/03/ ... s1_OPH.htm</a> </p><p></p><p></p><p></p><p>2) Infectious dose: </p><p></p><p>To cattle: 1 gram of infected brain material (by oral ingestion) </p><p></p><p></p><p><a href="http://www.inspection.gc.ca/english/sci/bio/bseesbe.shtml" target="_blank">http://www.inspection.gc.ca/english/sci ... esbe.shtml</a> </p><p></p><p></p><p>Terry S. Singeltary Sr. </p><p></p><p>P.O. Box 42 </p><p></p><p>Bacliff, Texas USA 77518 </p><p></p><p></p><p>[Docket No. 03-025IFA] FSIS Prohibition of the Use of Specified Risk Materials for Human Food and Requirement for the Disposition of Non-Ambulatory Disabled Cattle </p><p></p><p>03-025IFA</p><p>03-025IFA-2</p><p>Terry S. Singeltary </p><p></p><p></p><p>Page 1 of 17 </p><p></p><p>From: Terry S. Singeltary Sr. [flounder9@verizon.net] </p><p></p><p>Sent: Thursday, September 08, 2005 6:17 PM </p><p></p><p>To: <a href="mailto:fsis.regulationscomments@fsis.usda.gov">fsis.regulationscomments@fsis.usda.gov</a> </p><p></p><p>Subject: [Docket No. 03-025IFA] FSIS Prohibition of the Use of Specified Risk Materials for Human Food and Requirements </p><p></p><p>for the Disposition of Non-Ambulatory Disabled Cattle </p><p></p><p>Greetings FSIS, </p><p></p><p>I would kindly like to submit the following to [Docket No. 03-025IFA] FSIS Prohibition of the Use of Specified Risk Materials for Human Food and </p><p></p><p>Requirements for the Disposition of Non-Ambulatory Disabled Cattle </p><p></p><p>THE BSE/TSE SUB CLINICAL Non-Ambulatory Disabled Cattle </p><p></p><p>Broken bones and such may be the first signs of a sub clinical BSE/TSE Non-Ambulatory Disabled Cattle ; </p><p></p><p>SUB CLINICAL PRION INFECTION </p><p></p><p>MRC-43-00 </p><p></p><p>Issued: Monday, 28 August 2000 </p><p></p><p>NEW EVIDENCE OF SUB-CLINICAL PRION INFECTION: IMPORTANT RESEARCH </p><p></p><p>FINDINGS RELEVANT TO CJD AND BSE </p><p></p><p></p><p>Terry S. Singeltary Sr. </p><p></p><p>P.O. Box 42 </p><p></p><p>Bacliff, Texas USA 77518 </p><p></p><p>9/13/2005 </p><p></p><p><a href="http://www.fsis.usda.gov/OPPDE/Comments/03-025IFA/03-025IFA-2.pdf" target="_blank">http://www.fsis.usda.gov/OPPDE/Comments ... 5IFA-2.pdf</a> </p><p></p><p> </p><p></p><p>TSS</p></blockquote><p></p>
[QUOTE="flounder, post: 255090, member: 3519"] Subject: MAD COW FEED RECALL MI MAMMALIAN PROTEIN VOLUME OF PRODUCT IN COMMERCE 27,694,240 lbs Date: August 6, 2006 at 6:14 pm PST PRODUCT Bulk custom dairy feds manufactured from concentrates, Recall # V-113-6 CODE All dairy feeds produced between 2/1/05 and 6/16/06 and containing H. J. Baker recalled feed products. RECALLING FIRM/MANUFACTURER Vita Plus Corp., Gagetown, MI, by visit beginning on June 21, 2006. Firm initiated recall is complete. REASON The feed was manufactured from materials that may have been contaminated with mammalian protein. VOLUME OF PRODUCT IN COMMERCE 27,694,240 lbs DISTRIBUTION MI END OF ENFORCEMENT REPORT FOR AUGUST 2, 2006 ### [url=http://www.fda.gov/bbs/topics/enforce/2006/ENF00963.html]http://www.fda.gov/bbs/topics/enforce/2 ... 00963.html[/url] WE know now, and we knew decades ago, that 5.5 grams of suspect feed in TEXAS was enough to kill 100 cows. look at the table and you'll see that as little as 1 mg (or 0.001 gm) caused 7% (1 of 14) of the cows to come down with BSE; Risk of oral infection with bovine spongiform encephalopathy agent in primates Corinne Ida Lasmézas, Emmanuel Comoy, Stephen Hawkins, Christian Herzog, Franck Mouthon, Timm Konold, Frédéric Auvré, Evelyne Correia, Nathalie Lescoutra-Etchegaray, Nicole Salès, Gerald Wells, Paul Brown, Jean-Philippe Deslys Summary The uncertain extent of human exposure to bovine spongiform encephalopathy (BSE)--which can lead to variant Creutzfeldt-Jakob disease (vCJD)--is compounded by incomplete knowledge about the efficiency of oral infection and the magnitude of any bovine-to-human biological barrier to transmission. We therefore investigated oral transmission of BSE to non-human primates. We gave two macaques a 5 g oral dose of brain homogenate from a BSE-infected cow. One macaque developed vCJD-like neurological disease 60 months after exposure, whereas the other remained free of disease at 76 months. On the basis of these findings and data from other studies, we made a preliminary estimate of the food exposure risk for man, which provides additional assurance that existing public health measures can prevent transmission of BSE to man. snip... BSE bovine brain inoculum 100 g 10 g 5 g 1 g 100 mg 10 mg 1 mg 0·1 mg 0·01 mg Primate (oral route)* 1/2 (50%) Cattle (oral route)* 10/10 (100%) 7/9 (78%) 7/10 (70%) 3/15 (20%) 1/15 (7%) 1/15 (7%) RIII mice (ic ip route)* 17/18 (94%) 15/17 (88%) 1/14 (7%) PrPres biochemical detection The comparison is made on the basis of calibration of the bovine inoculum used in our study with primates against a bovine brain inoculum with a similar PrPres concentration that was inoculated into mice and cattle.8 *Data are number of animals positive/number of animals surviving at the time of clinical onset of disease in the first positive animal (%). The accuracy of bioassays is generally judged to be about plus or minus 1 log. ic ip=intracerebral and intraperitoneal. Table 1: Comparison of transmission rates in primates and cattle infected orally with similar BSE brain inocula Published online January 27, 2005 [url=http://www.thelancet.com/journal/journal.isa]http://www.thelancet.com/journal/journal.isa[/url] It is clear that the designing scientists must also have shared Mr Bradley’s surprise at the results because all the dose levels right down to 1 gram triggered infection. [url=http://www.bseinquiry.gov.uk/files/ws/s145d.pdf]http://www.bseinquiry.gov.uk/files/ws/s145d.pdf[/url] 2 6. It also appears to me that Mr Bradley’s answer (that it would take less than say 100 grams) was probably given with the benefit of hindsight; particularly if one considers that later in the same answer Mr Bradley expresses his surprise that it could take as little of 1 gram of brain to cause BSE by the oral route within the same species. This information did not become available until the "attack rate" experiment had been completed in 1995/96. This was a titration experiment designed to ascertain the infective dose. A range of dosages was used to ensure that the actual result was within both a lower and an upper limit within the study and the designing scientists would not have expected all the dose levels to trigger infection. The dose ranges chosen by the most informed scientists at that time ranged from 1 gram to three times one hundred grams. It is clear that the designing scientists must have also shared Mr Bradley’s surprise at the results because all the dose levels right down to 1 gram triggered infection. [url=http://www.bseinquiry.gov.uk/files/ws/s147f.pdf]http://www.bseinquiry.gov.uk/files/ws/s147f.pdf[/url] Re: BSE .1 GRAM LETHAL NEW STUDY SAYS via W.H.O. Dr Maura Ricketts [BBC radio 4 FARM news] [url=http://www.maddeer.org/audio/BBC4farmingtoday2_1_03.ram]http://www.maddeer.org/audio/BBC4farmingtoday2_1_03.ram[/url] [url=http://www.fda.gov/ohrms/dockets/ac/03/slides/3923s1_OPH.htm]http://www.fda.gov/ohrms/dockets/ac/03/ ... s1_OPH.htm[/url] 2) Infectious dose: To cattle: 1 gram of infected brain material (by oral ingestion) [url=http://www.inspection.gc.ca/english/sci/bio/bseesbe.shtml]http://www.inspection.gc.ca/english/sci ... esbe.shtml[/url] Terry S. Singeltary Sr. P.O. Box 42 Bacliff, Texas USA 77518 [Docket No. 03-025IFA] FSIS Prohibition of the Use of Specified Risk Materials for Human Food and Requirement for the Disposition of Non-Ambulatory Disabled Cattle 03-025IFA 03-025IFA-2 Terry S. Singeltary Page 1 of 17 From: Terry S. Singeltary Sr. [flounder9@verizon.net] Sent: Thursday, September 08, 2005 6:17 PM To: [email=fsis.regulationscomments@fsis.usda.gov]fsis.regulationscomments@fsis.usda.gov[/email] Subject: [Docket No. 03-025IFA] FSIS Prohibition of the Use of Specified Risk Materials for Human Food and Requirements for the Disposition of Non-Ambulatory Disabled Cattle Greetings FSIS, I would kindly like to submit the following to [Docket No. 03-025IFA] FSIS Prohibition of the Use of Specified Risk Materials for Human Food and Requirements for the Disposition of Non-Ambulatory Disabled Cattle THE BSE/TSE SUB CLINICAL Non-Ambulatory Disabled Cattle Broken bones and such may be the first signs of a sub clinical BSE/TSE Non-Ambulatory Disabled Cattle ; SUB CLINICAL PRION INFECTION MRC-43-00 Issued: Monday, 28 August 2000 NEW EVIDENCE OF SUB-CLINICAL PRION INFECTION: IMPORTANT RESEARCH FINDINGS RELEVANT TO CJD AND BSE Terry S. Singeltary Sr. P.O. Box 42 Bacliff, Texas USA 77518 9/13/2005 [url=http://www.fsis.usda.gov/OPPDE/Comments/03-025IFA/03-025IFA-2.pdf]http://www.fsis.usda.gov/OPPDE/Comments ... 5IFA-2.pdf[/url] TSS [/QUOTE]
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MAD COW FEED RECALL MI MAMMALIAN PROTEIN 27,694,240 lbs
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