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Lyme disease - Vicki please read
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<blockquote data-quote="Vicky the vet" data-source="post: 92405" data-attributes="member: 1026"><p>A very large number of horses is treated presumptively each year for Lyme disease. Treatment is often prolonged, expensive and carries some chance of toxicity. Virtually all cases of equine Lyme disease are treated with doxycycline, tetracycline or ceftiofur. Based upon treatment of Lyme disease in other species, any use of these antibiotics in horses could be justified. Unfortunately, other than the rare equine case that has a pre- and post-treatment synovial biopsy there is no evidence to suggest which drug would be most effective in treating Borrelia infection and its associated synovitis. Borrelia has a strong predilection to infect skin and synovial membranes in the horse, as has been shown in our previous experimental work. This finding helps support the belief of equine practitioners that stiffness/lameness is a common sign of Lyme disease in the horse....</p><p></p><p>4. Treatment Study</p><p>In a third and separate study, naîve ponies were infected with B. burgdorferi, and after infection, ponies were treated with either tetracycline [a] (6.6 mg/kg IV, q 12 h), doxycycline <strong> (10 mg/kg PO, q 12 h), or ceftiofur [c]. (2.2 mg/kg IM, q 12 h). All treatments were for 3 wk. Ponies were euthanized 4 mo after treatment was discontinued. Serology was performed every 3 wk throughout the study period. All ponies treated with tetracycline had a progressive decline in ELISA units at the time of euthanasia. Tetracycline-treated ponies were negative on both culture and PCR. Doxycycline and ceftiofur produced inconsistent results in serologic response and culture findings.</strong></p><p><strong>....</strong></p><p><strong></strong></p><p><strong>This is information from two studies on Lyme in horses. I hope this helps...</strong></p><p><strong>V</strong></p></blockquote><p></p>
[QUOTE="Vicky the vet, post: 92405, member: 1026"] A very large number of horses is treated presumptively each year for Lyme disease. Treatment is often prolonged, expensive and carries some chance of toxicity. Virtually all cases of equine Lyme disease are treated with doxycycline, tetracycline or ceftiofur. Based upon treatment of Lyme disease in other species, any use of these antibiotics in horses could be justified. Unfortunately, other than the rare equine case that has a pre- and post-treatment synovial biopsy there is no evidence to suggest which drug would be most effective in treating Borrelia infection and its associated synovitis. Borrelia has a strong predilection to infect skin and synovial membranes in the horse, as has been shown in our previous experimental work. This finding helps support the belief of equine practitioners that stiffness/lameness is a common sign of Lyme disease in the horse.... 4. Treatment Study In a third and separate study, naîve ponies were infected with B. burgdorferi, and after infection, ponies were treated with either tetracycline [a] (6.6 mg/kg IV, q 12 h), doxycycline [b] (10 mg/kg PO, q 12 h), or ceftiofur [c]. (2.2 mg/kg IM, q 12 h). All treatments were for 3 wk. Ponies were euthanized 4 mo after treatment was discontinued. Serology was performed every 3 wk throughout the study period. All ponies treated with tetracycline had a progressive decline in ELISA units at the time of euthanasia. Tetracycline-treated ponies were negative on both culture and PCR. Doxycycline and ceftiofur produced inconsistent results in serologic response and culture findings. .... This is information from two studies on Lyme in horses. I hope this helps... V[/b] [/QUOTE]
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