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<blockquote data-quote="Lucky_P" data-source="post: 1253924" data-attributes="member: 12607"><p>In English...</p><p>Cattle(particularly calves) ingest the MAP bacteria. MAP are absorbed, intact, through specialized intestinal epithelial cells(Momotani cells, situated over the top of islands of lymphoid tissue in the small intestine), and are phagocytosed(ingested) by macrophages(mononuclear white blood cells) in the submucosa of the intestine. </p><p>Macrophages can kill most bacteria - but MAP lives happily inside the macrophages, and continues to grow and reproduce. Eventually, that macrophage ruptures, releasing all the MAP that grew inside it. More macrophages are recruited to ingest the MAP organisms. Rinse, repeat. Eventually, the accumulation of all those white blood cells recruited in an effort to corral/clean up the infection - which they're unable to do, effectively - causes thickening of the gut wall, and interferes with normal nutrient absorption. Diarrhea and tissue wasting(loss of body condition) results as a consequence of diminished nutrient absorption. </p><p></p><p>Diagnosis is problematic...</p><p>Because these Johne's-infected animals are exposed in utero or at an extremely young age, and because the macrophages cannot effectively kill the bacteria and present bacterial antigens to other immune cells... we see a condition of 'oral tolerance' - the animal's immune system does not 'recognize' the MAP bacteria as a 'foreign' agent until it reaches a critical 'tipping point' and the animal does not produce antibodies against MAP until just about the time they break with clinical disease... profuse diarrhea,wasting, and heavy fecal shedding of the infectious organisms. </p><p>So... these animals, which may have been infected very early in their life may not give a positive blood test or fecal culture until they are 3, 4, 5 (or more) years old...</p></blockquote><p></p>
[QUOTE="Lucky_P, post: 1253924, member: 12607"] In English... Cattle(particularly calves) ingest the MAP bacteria. MAP are absorbed, intact, through specialized intestinal epithelial cells(Momotani cells, situated over the top of islands of lymphoid tissue in the small intestine), and are phagocytosed(ingested) by macrophages(mononuclear white blood cells) in the submucosa of the intestine. Macrophages can kill most bacteria - but MAP lives happily inside the macrophages, and continues to grow and reproduce. Eventually, that macrophage ruptures, releasing all the MAP that grew inside it. More macrophages are recruited to ingest the MAP organisms. Rinse, repeat. Eventually, the accumulation of all those white blood cells recruited in an effort to corral/clean up the infection - which they're unable to do, effectively - causes thickening of the gut wall, and interferes with normal nutrient absorption. Diarrhea and tissue wasting(loss of body condition) results as a consequence of diminished nutrient absorption. Diagnosis is problematic... Because these Johne's-infected animals are exposed in utero or at an extremely young age, and because the macrophages cannot effectively kill the bacteria and present bacterial antigens to other immune cells... we see a condition of 'oral tolerance' - the animal's immune system does not 'recognize' the MAP bacteria as a 'foreign' agent until it reaches a critical 'tipping point' and the animal does not produce antibodies against MAP until just about the time they break with clinical disease... profuse diarrhea,wasting, and heavy fecal shedding of the infectious organisms. So... these animals, which may have been infected very early in their life may not give a positive blood test or fecal culture until they are 3, 4, 5 (or more) years old... [/QUOTE]
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