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NCBA, R-CALF, COOL, USDA (No Politics!)
Evaluation of the Human Transmission Risk of an Atypical BSE
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<blockquote data-quote="flounder" data-source="post: 496449" data-attributes="member: 3519"><p>Thursday, January 31, 2008</p><p></p><p>Evaluation of the Human Transmission Risk of an Atypical Bovine Spongiform Encephalopathy Prion Strain </p><p></p><p>J. Virol. doi:10.1128/JVI.02561-07</p><p>Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. </p><p>All Rights Reserved.</p><p></p><p></p><p></p><p>Thursday, January 31, 2008</p><p>Evaluation of the Human Transmission Risk of an Atypical Bovine Spongiform Encephalopathy Prion Strain </p><p>J. Virol. doi:10.1128/JVI.02561-07</p><p>Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.</p><p></p><p>Evaluation of the Human Transmission Risk of an Atypical Bovine Spongiform Encephalopathy Prion Strain</p><p></p><p>Qingzhong Kong*, Mengjie Zheng, Cristina Casalone, Liuting Qing, Shenghai Huang, Bikram Chakraborty, Ping Wang, Fusong Chen, Ignazio Cali, Cristiano Corona, Francesca Martucci, Barbara Iulini, Pierluigi Acutis, Lan Wang, Jingjing Liang, Meiling Wang, Xinyi Li, Salvatore Monaco, Gianluigi Zanusso, Wen-Quan Zou, Maria Caramelli, and Pierluigi Gambetti*</p><p>Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA; CEA, Istituto Zooprofilattico Sperimentale, 10154 Torino, Italy; Department of Neurological and Visual Sciences, University of Verona, 37134 Verona, Italy</p><p></p><p></p><p></p><p>* To whom correspondence should be addressed. Email: <a href="mailto:qxk2@case.edu">qxk2@case.edu</a>. <a href="mailto:pxg13@case.edu">pxg13@case.edu</a>.</p><p></p><p></p><p>Abstract</p><p></p><p></p><p>Bovine spongiform encephalopathy (BSE), the prion disease in cattle, was widely believed to have only one strain (BSE-C). BSE-C causes the fatal prion disease named new variant Creutzfeldt-Jacob disease in humans. Two atypical BSE strains, BASE (or BSE-L) and BSE-H, have been discovered in several countries since 2004; their transmissibility and phenotypes in humans are unknown. We investigated the infectivity and human phenotype of BASE by inoculating transgenic (Tg) mice expressing the human prion protein with brain homogenates from two BASE-affected cattle. Sixty percent of the inoculated Tg mice became infected after 20-22 months incubation, a transmission rate higher than those reported for BSE-C. A quarter of BASE-infected Tg mice, but none of the Tg mice infected with a sporadic human prion disease, showed presence of pathogenic prion protein isoforms in the spleen, indicating that the BASE prion is intrinsically lymphotropic. The pathological prion protein isoforms in BASE-infected humanized Tg mouse brains are different from those of the original cattle BASE or sporadic human prion disease. Minimal brain spongiosis and long incubation time are observed in the BASE-infected Tg mice. These results suggest that, in humans, BASE is a more virulent BSE strain and likely lymphotropic.</p><p></p><p></p><p><a href="http://jvi.asm.org/cgi/content/abstract/JVI.02561-07v1?papetoc" target="_blank">http://jvi.asm.org/cgi/content/abstract ... v1?papetoc</a></p><p></p><p></p><p>Thursday, January 31, 2008</p><p></p><p>SPONGIFORM ENCEPHALOPATHY ADVISORY COMMITTEE Draft minutes of the 99th</p><p>meeting held on 14th December 2007</p><p></p><p></p><p>snip...</p><p></p><p></p><p>snip...</p><p></p><p></p><p>ITEM 8 – PUBLIC QUESTION AND ANSWER SESSION</p><p></p><p></p><p>40. The Chair explained that the purpose of the question and answer</p><p>session was to give members of the public an opportunity to ask</p><p>questions related to the work of SEAC. Mr Terry Singeltary</p><p>(Texas, USA) had submitted a question prior to the meeting,</p><p>asking: "With the Nor-98 now documented in five different states so</p><p>far in the USA in 2007, and with the two atypical BSE H-base</p><p></p><p></p><p>13</p><p>© SEAC 2007</p><p></p><p></p><p>cases in Texas and Alabama, with both scrapie and chronic</p><p>wasting disease (CWD) running rampant in the USA, is there any</p><p>concern from SEAC with the rise of sporadic CJD in the USA from</p><p>''unknown phenotype'', and what concerns if any, in relations to</p><p>blood donations, surgery, optical, and dental treatment, do you</p><p>have with these unknown atypical phenotypes in both humans and</p><p>animals in the USA? Does it concern SEAC, or is it of no concern</p><p>to SEAC? Should it concern USA animal and human health</p><p>officials?"</p><p></p><p></p><p>41. A member considered that this question ............</p><p></p><p></p><p>snip... please see full text, sources, and comments here ;</p><p></p><p></p><p><a href="http://seac992007.blogspot.com/2008/01/spongiform-encephalopathy-advisory.html" target="_blank">http://seac992007.blogspot.com/2008/01/ ... isory.html</a></p><p></p><p></p><p>APHIS-2006-0041-0006 TSE advisory committee for the meeting December 15,</p><p>2006</p><p></p><p></p><p><a href="http://www.regulations.gov/fdmspublic/ContentViewer?objectId=09000064801f3413&disposition=attachment&contentType=msw8" target="_blank">http://www.regulations.gov/fdmspublic/C ... tType=msw8</a></p><p></p><p></p><p>[Docket No. FSIS-2006-0011] FSIS Harvard Risk Assessment of Bovine</p><p>Spongiform Encephalopathy (BSE)</p><p></p><p></p><p><a href="http://www.fsis.usda.gov/OPPDE/Comments/2006-0011/2006-0011-1.pdf" target="_blank">http://www.fsis.usda.gov/OPPDE/Comments ... 0011-1.pdf</a></p><p></p><p></p><p></p><p>[Docket No. 03-025IFA] FSIS Prohibition of the Use of Specified Risk Materials for Human Food and Requirement for the Disposition of Non-Ambulatory Disabled Cattle</p><p></p><p></p><p><a href="http://www.fsis.usda.gov/OPPDE/Comments/03-025IFA/03-025IFA-2.pdf" target="_blank">http://www.fsis.usda.gov/OPPDE/Comments ... 5IFA-2.pdf</a></p><p></p><p></p><p></p><p>Attachment to Singletary comment</p><p></p><p>January 28, 2007</p><p></p><p></p><p>Greetings APHIS,</p><p></p><p></p><p>I would kindly like to submit the following to ;</p><p></p><p></p><p>BSE; MRR; IMPORTATION OF LIVE BOVINES AND PRODUCTS DERIVED FROM BOVINES</p><p>[Docket No. APHIS-2006-0041] RIN 0579-AC01</p><p></p><p></p><p></p><p>[Federal Register: January 9, 2007 (Volume 72, Number 5)]</p><p>[Proposed Rules]</p><p>[Page 1101-1129]</p><p>From the Federal Register Online via GPO Access [wais.access.gpo.gov]</p><p>[DOCID:fr09ja07-21]</p><p></p><p></p><p></p><p><a href="http://www.regulations.gov/fdmspublic/component/main?main=DocumentDetail&o=09000064801f8152" target="_blank">http://www.regulations.gov/fdmspublic/c ... 64801f8152</a></p><p></p><p></p><p></p><p>BSE; MRR; IMPORTATION OF LIVE BOVINES AND PRODUCTS</p><p>DERIVED FROM BOVINES [Docket No. APHIS-2006-0041] RIN 0579-AC01</p><p>Date: January 9, 2007 at 9:08 am PST</p><p></p><p></p><p><a href="http://www.regulations.gov/fdmspublic/component/main?main=DocumentDetail&o=09000064801f3412" target="_blank">http://www.regulations.gov/fdmspublic/c ... 64801f3412</a></p><p></p><p></p><p></p><p>Diagnosis and Reporting of Creutzfeldt-Jakob Disease</p><p></p><p>Singeltary, Sr et al. JAMA.2001; 285: 733-734.</p><p></p><p></p><p>Diagnosis and Reporting of Creutzfeldt-Jakob Disease</p><p></p><p>Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.</p><p></p><p></p><p>To the Editor:</p><p></p><p>In their Research Letter, Dr Gibbons and colleagues1 reported that the annual US death rate due to Creutzfeldt-Jakob disease (CJD) has been stable since 1985. These estimates, however, are based only on reported cases, and do not include misdiagnosed or preclinical cases. It seems to me that misdiagnosis alone would drastically change these figures. An unknown number of persons with a diagnosis of Alzheimer disease in fact may have CJD, although only a small number of these patients receive the postmortem examination necessary to make this diagnosis. Furthermore, only a few states have made CJD reportable. Human and animal transmissible spongiform encephalopathies should be reportable nationwide and internationally.</p><p></p><p>Terry S. Singeltary, Sr</p><p>Bacliff, Tex</p><p></p><p></p><p></p><p>1. Gibbons RV, Holman RC, Belay ED, Schonberger LB. Creutzfeldt-Jakob disease in the United States: 1979-1998. JAMA. 2000;284:2322-2323. FREE FULL TEXT</p><p></p><p></p><p><a href="http://jama.ama-assn.org/cgi/content/extract/285/6/733?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=singeltary&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT" target="_blank">http://jama.ama-assn.org/cgi/content/ex ... type=HWCIT</a></p><p></p><p></p><p></p><p>PDF]Freas, William TSS SUBMISSION</p><p>File Format: PDF/Adobe Acrobat -Page 1. J Freas, William From: Sent:</p><p>To:</p><p>Subject:</p><p>Terry S. SingeltarySr. [flounder@wt.net]</p><p>Monday, January 08,200l 3:03 PM freas ...</p><p></p><p><a href="http://www.fda.gov/ohrms/dockets/ac/01/slides/3681s2_09.pdf" target="_blank">http://www.fda.gov/ohrms/dockets/ac/01/ ... 1s2_09.pdf</a></p><p></p><p></p><p>Asante/Collinge et al, that BSE transmission to the 129-methionine genotype can lead to an alternate phenotype that is indistinguishable from type 2 PrPSc, the commonest _sporadic_ CJD;</p><p></p><p><a href="http://www.fda.gov/ohrms/dockets/ac/03/slides/3923s1_OPH.htm" target="_blank">http://www.fda.gov/ohrms/dockets/ac/03/ ... s1_OPH.htm</a></p><p></p><p></p><p>DER SPIEGEL (9/2001) - 24.02.2001 (9397 Zeichen)USA: Loch in der MauerDie BSE-Angst erreicht Amerika: Trotz strikter Auflagen gelangte in Texas verbotenes Tiermehl ins Rinderfutter - die Kontrollen der Aufsichtsbehördensind lax.Link auf diesen Artikel im Archiv:http://service.spiegel.de/digas/find?DID=18578755</p><p></p><p></p><p>"Its as full of holes as Swiss Cheese" says Terry Singeltary of the FDA regulations. ...</p><p></p><p></p><p><a href="http://service.spiegel.de/digas/servlet/find/DID=18578755" target="_blank">http://service.spiegel.de/digas/servlet ... D=18578755</a></p><p></p><p></p><p>2 January 2000</p><p></p><p>British Medical Journal</p><p></p><p>U.S. Scientist should be concerned with a CJD epidemic in the U.S., as well</p><p></p><p><a href="http://www.bmj.com/cgi/eletters/320/7226/8/b#6117" target="_blank">http://www.bmj.com/cgi/eletters/320/7226/8/b#6117</a></p><p></p><p></p><p>15 November 1999</p><p></p><p>British Medical Journal</p><p></p><p>vCJD in the USA * BSE in U.S.</p><p></p><p></p><p><a href="http://www.bmj.com/cgi/eletters/319/7220/1312/b#5406" target="_blank">http://www.bmj.com/cgi/eletters/319/7220/1312/b#5406</a></p><p></p><p></p><p>please notice Texas 2006 ;</p><p></p><p>† Confirmed in United Kingdom and reported to Texas Department of State</p><p>Health Services</p><p>through Centers for Disease Control and Prevention.</p><p></p><p></p><p>Only 1 case of variant</p><p>CJD has ever been diagnosed in Texas.</p><p>The patient was a former resident of the</p><p>United Kingdom, where the exposure</p><p>was likely to have occurred. Texas has a</p><p>population of 23 million, and since the</p><p>national rate of sporadic CJD is about 1</p><p>per million, it is expected that</p><p>approximately 23 cases of CJD would</p><p>occur each year in the state. Therefore,</p><p>it is believed that CJD is currently underreported</p><p>in Texas. ...END...TSS</p><p></p><p></p><p>also see ;</p><p></p><p></p><p><a href="http://www.dshs.state.tx.us/idcu/disease/creutzfeldt-jakob/data/" target="_blank">http://www.dshs.state.tx.us/idcu/diseas ... akob/data/</a></p><p></p><p></p><p>Creutzfeldt-Jakob Disease in Northeast Texas,</p><p></p><p>J.A. Rawlings,*1 K.A.</p><p>Hendricks1, O.M. Nuno1, D.A. Brown1, D.A. Evans2, Texas Department of</p><p>Health, 1Austin and 2Tyler, Texas</p><p></p><p></p><p>Creutzfeldt-Jacob Disease (CJD), a transmissible spongiform</p><p>encephalopathy, is caused by prions composed of proteinaceous material</p><p>devoid of nucleic acid. CJD occurs sporadically (generally 1</p><p>case/1,000,000 population per year) in older patients (average age of</p><p>65) and is characterized by rapidly progressive dementia, accompanied by</p><p>severe muscle spasms and incoordination. Death usually occurs within 3</p><p>to 12 months (average 7 months). CJD activity in Texas, which has a</p><p>population of nearly 19 million, appeared to be typical. The statewide</p><p>death rate for 1995 and 1996 was just under 1/1,000,000. In April of</p><p>1997, the Texas Department of Health became aware of an increased number</p><p>of possible CJD cases in a 23-county area of NE Texas with a population</p><p>of just over one million. After review of medical and pathology records,</p><p>four patients were identified with definite classic CJD and three were</p><p>identified with probable CJD. Dates of death for the eight patients were</p><p>from April, 1996 through mid-July 1997. The patients were from 46</p><p>through 65 years of age; four were male and three were female. A</p><p>case-control study to identify risks for CJD in NE Texas has been initiated.</p><p></p><p></p><p><a href="http://www.jifsan.umd.edu/tse/Rawlings.htm" target="_blank">http://www.jifsan.umd.edu/tse/Rawlings.htm</a></p><p></p><p></p><p>Division of Neuropathology</p><p>Pierluigi Gambetti, M.D.,</p><p>Director</p><p></p><p>-----------------------------------</p><p></p><p>CASE WESTERN RESERVE UNIVERSITY</p><p></p><p>March 30, 1998</p><p></p><p>Dr. Gerald A, Campbell</p><p></p><p>The University of Texas</p><p>Medical Branch at Galveston</p><p>Division of Neuropathology</p><p>Department of Pathology</p><p>Galveston, Texas</p><p></p><p>Dear Dr Campbell,</p><p></p><p>We performed Western immunoblot analysis on the frozen tissue from your case</p><p>#AU97-435 (our #098-28). The Immunoblot reveals the presence of</p><p>protease-resistant prion protein (PrPres) confirming the diagnosis of prion</p><p>disease. The immunoblot pattern of PrPres is consistent with the diagnosis</p><p>of Creutzfeldt-Jakob disease.</p><p></p><p>Thank you for referring to us this interesting case.</p><p></p><p></p><p>Sincerely,</p><p></p><p>Piero Parchi, M.D.</p><p></p><p>Pierluigi Gambetti, M.D.</p><p></p><p>PP:sbDivision of Neuropathology</p><p></p><p>Pierluigi Gambetti, M.D.,</p><p></p><p>Director</p><p></p><p>Case Western Reserve University</p><p></p><p>snip...end</p><p></p><p></p><p>see full text ;</p><p></p><p></p><p><a href="http://cjdtexas.blogspot.com/" target="_blank">http://cjdtexas.blogspot.com/</a></p><p></p><p></p><p>Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in</p><p>the United States</p><p></p><p><a href="http://cjdusa.blogspot.com/" target="_blank">http://cjdusa.blogspot.com/</a></p><p></p><p></p><p>Creutzfeldt Jakob Disease</p><p></p><p><a href="http://creutzfeldt-jakob-disease.blogspot.com/" target="_blank">http://creutzfeldt-jakob-disease.blogspot.com/</a></p><p></p><p></p><p>Creutzfeldt-Jakob Disease, Prion Protein Gene Codon 129VV, and a Novel PrPSc Type in a Young British Woman</p><p></p><p></p><p><a href="http://creutzfeldt-jakob-disease.blogspot.com/2008/01/creutzfeldt-jakob-disease-prion-protein.html" target="_blank">http://creutzfeldt-jakob-disease.blogsp ... otein.html</a></p><p></p><p></p><p>CJD QUESTIONNAIRE</p><p></p><p><a href="http://cjdquestionnaire.blogspot.com/" target="_blank">http://cjdquestionnaire.blogspot.com/</a></p><p></p><p></p><p>ANIMAL HEALTH REPORT 2006 (BSE h-BASE EVENT IN ALABAMA, Scrapie, and CWD)</p><p></p><p><a href="http://animalhealthreport2006.blogspot.com/" target="_blank">http://animalhealthreport2006.blogspot.com/</a></p><p></p><p></p><p>CREUTZFELDT JAKOB DISEASE MAD COW BASE UPDATE USA</p><p></p><p><a href="http://cjdmadcowbaseoct2007.blogspot.com/" target="_blank">http://cjdmadcowbaseoct2007.blogspot.com/</a></p><p></p><p></p><p>Friday, January 11, 2008</p><p></p><p>CJD HUMAN TSE REPORT UK, USA, CANADA, and Mexico JANUARY 2008</p><p></p><p></p><p><a href="http://cjdmadcowbaseoct2007.blogspot.com/2008/01/cjd-human-tse-report-uk-usa-canada-and.html" target="_blank">http://cjdmadcowbaseoct2007.blogspot.co ... a-and.html</a></p><p></p><p></p><p>Friday, January 25, 2008</p><p>January 2008 Update on Feed Enforcement Activities to Limit the Spread of BSE</p><p></p><p><a href="http://madcowspontaneousnot.blogspot.com/2008/01/january-2008-update-on-feed-enforcement.html" target="_blank">http://madcowspontaneousnot.blogspot.co ... ement.html</a></p><p></p><p><a href="http://madcowspontaneousnot.blogspot.com/" target="_blank">http://madcowspontaneousnot.blogspot.com/</a></p><p></p><p></p><p>BSE BASE MAD COW TESTING TEXAS, USA, AND CANADA</p><p></p><p><a href="http://madcowtesting.blogspot.com/" target="_blank">http://madcowtesting.blogspot.com/</a></p><p></p><p></p><p>NOR-98 ATYPICAL SCRAPIE USA UPDATE AS AT OCT 2007</p><p></p><p><a href="http://nor-98.blogspot.com/" target="_blank">http://nor-98.blogspot.com/</a></p><p></p><p><a href="http://scrapie-usa.blogspot.com/" target="_blank">http://scrapie-usa.blogspot.com/</a></p><p></p><p></p><p>Terry S. Singeltary Sr.</p><p>P.O. Box 42</p><p>Bacliff, Texas USA 77518</p><p></p><p></p><p></p><p><a href="http://cjdmadcowbaseoct2007.blogspot.com/2008/01/evaluation-of-human-transmission-risk.html" target="_blank">http://cjdmadcowbaseoct2007.blogspot.co ... -risk.html</a></p><p></p><p><a href="http://cjdmadcowbaseoct2007.blogspot.com/" target="_blank">http://cjdmadcowbaseoct2007.blogspot.com/</a></p><p></p><p></p><p>TSS</p></blockquote><p></p>
[QUOTE="flounder, post: 496449, member: 3519"] Thursday, January 31, 2008 Evaluation of the Human Transmission Risk of an Atypical Bovine Spongiform Encephalopathy Prion Strain J. Virol. doi:10.1128/JVI.02561-07 Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Thursday, January 31, 2008 Evaluation of the Human Transmission Risk of an Atypical Bovine Spongiform Encephalopathy Prion Strain J. Virol. doi:10.1128/JVI.02561-07 Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Evaluation of the Human Transmission Risk of an Atypical Bovine Spongiform Encephalopathy Prion Strain Qingzhong Kong*, Mengjie Zheng, Cristina Casalone, Liuting Qing, Shenghai Huang, Bikram Chakraborty, Ping Wang, Fusong Chen, Ignazio Cali, Cristiano Corona, Francesca Martucci, Barbara Iulini, Pierluigi Acutis, Lan Wang, Jingjing Liang, Meiling Wang, Xinyi Li, Salvatore Monaco, Gianluigi Zanusso, Wen-Quan Zou, Maria Caramelli, and Pierluigi Gambetti* Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA; CEA, Istituto Zooprofilattico Sperimentale, 10154 Torino, Italy; Department of Neurological and Visual Sciences, University of Verona, 37134 Verona, Italy * To whom correspondence should be addressed. Email: [email=qxk2@case.edu]qxk2@case.edu[/email]. [email=pxg13@case.edu]pxg13@case.edu[/email]. Abstract Bovine spongiform encephalopathy (BSE), the prion disease in cattle, was widely believed to have only one strain (BSE-C). BSE-C causes the fatal prion disease named new variant Creutzfeldt-Jacob disease in humans. Two atypical BSE strains, BASE (or BSE-L) and BSE-H, have been discovered in several countries since 2004; their transmissibility and phenotypes in humans are unknown. We investigated the infectivity and human phenotype of BASE by inoculating transgenic (Tg) mice expressing the human prion protein with brain homogenates from two BASE-affected cattle. Sixty percent of the inoculated Tg mice became infected after 20-22 months incubation, a transmission rate higher than those reported for BSE-C. A quarter of BASE-infected Tg mice, but none of the Tg mice infected with a sporadic human prion disease, showed presence of pathogenic prion protein isoforms in the spleen, indicating that the BASE prion is intrinsically lymphotropic. The pathological prion protein isoforms in BASE-infected humanized Tg mouse brains are different from those of the original cattle BASE or sporadic human prion disease. Minimal brain spongiosis and long incubation time are observed in the BASE-infected Tg mice. These results suggest that, in humans, BASE is a more virulent BSE strain and likely lymphotropic. [url=http://jvi.asm.org/cgi/content/abstract/JVI.02561-07v1?papetoc]http://jvi.asm.org/cgi/content/abstract ... v1?papetoc[/url] Thursday, January 31, 2008 SPONGIFORM ENCEPHALOPATHY ADVISORY COMMITTEE Draft minutes of the 99th meeting held on 14th December 2007 snip... snip... ITEM 8 – PUBLIC QUESTION AND ANSWER SESSION 40. The Chair explained that the purpose of the question and answer session was to give members of the public an opportunity to ask questions related to the work of SEAC. Mr Terry Singeltary (Texas, USA) had submitted a question prior to the meeting, asking: “With the Nor-98 now documented in five different states so far in the USA in 2007, and with the two atypical BSE H-base 13 © SEAC 2007 cases in Texas and Alabama, with both scrapie and chronic wasting disease (CWD) running rampant in the USA, is there any concern from SEAC with the rise of sporadic CJD in the USA from ''unknown phenotype'', and what concerns if any, in relations to blood donations, surgery, optical, and dental treatment, do you have with these unknown atypical phenotypes in both humans and animals in the USA? Does it concern SEAC, or is it of no concern to SEAC? Should it concern USA animal and human health officials?” 41. A member considered that this question ............ snip... please see full text, sources, and comments here ; [url=http://seac992007.blogspot.com/2008/01/spongiform-encephalopathy-advisory.html]http://seac992007.blogspot.com/2008/01/ ... isory.html[/url] APHIS-2006-0041-0006 TSE advisory committee for the meeting December 15, 2006 [url=http://www.regulations.gov/fdmspublic/ContentViewer?objectId=09000064801f3413&disposition=attachment&contentType=msw8]http://www.regulations.gov/fdmspublic/C ... tType=msw8[/url] [Docket No. FSIS-2006-0011] FSIS Harvard Risk Assessment of Bovine Spongiform Encephalopathy (BSE) [url=http://www.fsis.usda.gov/OPPDE/Comments/2006-0011/2006-0011-1.pdf]http://www.fsis.usda.gov/OPPDE/Comments ... 0011-1.pdf[/url] [Docket No. 03-025IFA] FSIS Prohibition of the Use of Specified Risk Materials for Human Food and Requirement for the Disposition of Non-Ambulatory Disabled Cattle [url=http://www.fsis.usda.gov/OPPDE/Comments/03-025IFA/03-025IFA-2.pdf]http://www.fsis.usda.gov/OPPDE/Comments ... 5IFA-2.pdf[/url] Attachment to Singletary comment January 28, 2007 Greetings APHIS, I would kindly like to submit the following to ; BSE; MRR; IMPORTATION OF LIVE BOVINES AND PRODUCTS DERIVED FROM BOVINES [Docket No. APHIS-2006-0041] RIN 0579-AC01 [Federal Register: January 9, 2007 (Volume 72, Number 5)] [Proposed Rules] [Page 1101-1129] From the Federal Register Online via GPO Access [wais.access.gpo.gov] [DOCID:fr09ja07-21] [url=http://www.regulations.gov/fdmspublic/component/main?main=DocumentDetail&o=09000064801f8152]http://www.regulations.gov/fdmspublic/c ... 64801f8152[/url] BSE; MRR; IMPORTATION OF LIVE BOVINES AND PRODUCTS DERIVED FROM BOVINES [Docket No. APHIS-2006-0041] RIN 0579-AC01 Date: January 9, 2007 at 9:08 am PST [url=http://www.regulations.gov/fdmspublic/component/main?main=DocumentDetail&o=09000064801f3412]http://www.regulations.gov/fdmspublic/c ... 64801f3412[/url] Diagnosis and Reporting of Creutzfeldt-Jakob Disease Singeltary, Sr et al. JAMA.2001; 285: 733-734. Diagnosis and Reporting of Creutzfeldt-Jakob Disease Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. To the Editor: In their Research Letter, Dr Gibbons and colleagues1 reported that the annual US death rate due to Creutzfeldt-Jakob disease (CJD) has been stable since 1985. These estimates, however, are based only on reported cases, and do not include misdiagnosed or preclinical cases. It seems to me that misdiagnosis alone would drastically change these figures. An unknown number of persons with a diagnosis of Alzheimer disease in fact may have CJD, although only a small number of these patients receive the postmortem examination necessary to make this diagnosis. Furthermore, only a few states have made CJD reportable. Human and animal transmissible spongiform encephalopathies should be reportable nationwide and internationally. Terry S. Singeltary, Sr Bacliff, Tex 1. Gibbons RV, Holman RC, Belay ED, Schonberger LB. Creutzfeldt-Jakob disease in the United States: 1979-1998. JAMA. 2000;284:2322-2323. FREE FULL TEXT [url=http://jama.ama-assn.org/cgi/content/extract/285/6/733?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=singeltary&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT]http://jama.ama-assn.org/cgi/content/ex ... type=HWCIT[/url] PDF]Freas, William TSS SUBMISSION File Format: PDF/Adobe Acrobat -Page 1. J Freas, William From: Sent: To: Subject: Terry S. SingeltarySr. [flounder@wt.net] Monday, January 08,200l 3:03 PM freas ... [url=http://www.fda.gov/ohrms/dockets/ac/01/slides/3681s2_09.pdf]http://www.fda.gov/ohrms/dockets/ac/01/ ... 1s2_09.pdf[/url] Asante/Collinge et al, that BSE transmission to the 129-methionine genotype can lead to an alternate phenotype that is indistinguishable from type 2 PrPSc, the commonest _sporadic_ CJD; [url=http://www.fda.gov/ohrms/dockets/ac/03/slides/3923s1_OPH.htm]http://www.fda.gov/ohrms/dockets/ac/03/ ... s1_OPH.htm[/url] DER SPIEGEL (9/2001) - 24.02.2001 (9397 Zeichen)USA: Loch in der MauerDie BSE-Angst erreicht Amerika: Trotz strikter Auflagen gelangte in Texas verbotenes Tiermehl ins Rinderfutter - die Kontrollen der Aufsichtsbehördensind lax.Link auf diesen Artikel im Archiv:http://service.spiegel.de/digas/find?DID=18578755 "Its as full of holes as Swiss Cheese" says Terry Singeltary of the FDA regulations. ... [url=http://service.spiegel.de/digas/servlet/find/DID=18578755]http://service.spiegel.de/digas/servlet ... D=18578755[/url] 2 January 2000 British Medical Journal U.S. Scientist should be concerned with a CJD epidemic in the U.S., as well [url=http://www.bmj.com/cgi/eletters/320/7226/8/b#6117]http://www.bmj.com/cgi/eletters/320/7226/8/b#6117[/url] 15 November 1999 British Medical Journal vCJD in the USA * BSE in U.S. [url=http://www.bmj.com/cgi/eletters/319/7220/1312/b#5406]http://www.bmj.com/cgi/eletters/319/7220/1312/b#5406[/url] please notice Texas 2006 ; † Confirmed in United Kingdom and reported to Texas Department of State Health Services through Centers for Disease Control and Prevention. Only 1 case of variant CJD has ever been diagnosed in Texas. The patient was a former resident of the United Kingdom, where the exposure was likely to have occurred. Texas has a population of 23 million, and since the national rate of sporadic CJD is about 1 per million, it is expected that approximately 23 cases of CJD would occur each year in the state. Therefore, it is believed that CJD is currently underreported in Texas. ...END...TSS also see ; [url=http://www.dshs.state.tx.us/idcu/disease/creutzfeldt-jakob/data/]http://www.dshs.state.tx.us/idcu/diseas ... akob/data/[/url] Creutzfeldt-Jakob Disease in Northeast Texas, J.A. Rawlings,*1 K.A. Hendricks1, O.M. Nuno1, D.A. Brown1, D.A. Evans2, Texas Department of Health, 1Austin and 2Tyler, Texas Creutzfeldt-Jacob Disease (CJD), a transmissible spongiform encephalopathy, is caused by prions composed of proteinaceous material devoid of nucleic acid. CJD occurs sporadically (generally 1 case/1,000,000 population per year) in older patients (average age of 65) and is characterized by rapidly progressive dementia, accompanied by severe muscle spasms and incoordination. Death usually occurs within 3 to 12 months (average 7 months). CJD activity in Texas, which has a population of nearly 19 million, appeared to be typical. The statewide death rate for 1995 and 1996 was just under 1/1,000,000. In April of 1997, the Texas Department of Health became aware of an increased number of possible CJD cases in a 23-county area of NE Texas with a population of just over one million. After review of medical and pathology records, four patients were identified with definite classic CJD and three were identified with probable CJD. Dates of death for the eight patients were from April, 1996 through mid-July 1997. The patients were from 46 through 65 years of age; four were male and three were female. A case-control study to identify risks for CJD in NE Texas has been initiated. [url=http://www.jifsan.umd.edu/tse/Rawlings.htm]http://www.jifsan.umd.edu/tse/Rawlings.htm[/url] Division of Neuropathology Pierluigi Gambetti, M.D., Director ----------------------------------- CASE WESTERN RESERVE UNIVERSITY March 30, 1998 Dr. Gerald A, Campbell The University of Texas Medical Branch at Galveston Division of Neuropathology Department of Pathology Galveston, Texas Dear Dr Campbell, We performed Western immunoblot analysis on the frozen tissue from your case #AU97-435 (our #098-28). The Immunoblot reveals the presence of protease-resistant prion protein (PrPres) confirming the diagnosis of prion disease. The immunoblot pattern of PrPres is consistent with the diagnosis of Creutzfeldt-Jakob disease. Thank you for referring to us this interesting case. Sincerely, Piero Parchi, M.D. Pierluigi Gambetti, M.D. PP:sbDivision of Neuropathology Pierluigi Gambetti, M.D., Director Case Western Reserve University snip...end see full text ; [url=http://cjdtexas.blogspot.com/]http://cjdtexas.blogspot.com/[/url] Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States [url=http://cjdusa.blogspot.com/]http://cjdusa.blogspot.com/[/url] Creutzfeldt Jakob Disease [url=http://creutzfeldt-jakob-disease.blogspot.com/]http://creutzfeldt-jakob-disease.blogspot.com/[/url] Creutzfeldt-Jakob Disease, Prion Protein Gene Codon 129VV, and a Novel PrPSc Type in a Young British Woman [url=http://creutzfeldt-jakob-disease.blogspot.com/2008/01/creutzfeldt-jakob-disease-prion-protein.html]http://creutzfeldt-jakob-disease.blogsp ... otein.html[/url] CJD QUESTIONNAIRE [url=http://cjdquestionnaire.blogspot.com/]http://cjdquestionnaire.blogspot.com/[/url] ANIMAL HEALTH REPORT 2006 (BSE h-BASE EVENT IN ALABAMA, Scrapie, and CWD) [url=http://animalhealthreport2006.blogspot.com/]http://animalhealthreport2006.blogspot.com/[/url] CREUTZFELDT JAKOB DISEASE MAD COW BASE UPDATE USA [url=http://cjdmadcowbaseoct2007.blogspot.com/]http://cjdmadcowbaseoct2007.blogspot.com/[/url] Friday, January 11, 2008 CJD HUMAN TSE REPORT UK, USA, CANADA, and Mexico JANUARY 2008 [url=http://cjdmadcowbaseoct2007.blogspot.com/2008/01/cjd-human-tse-report-uk-usa-canada-and.html]http://cjdmadcowbaseoct2007.blogspot.co ... a-and.html[/url] Friday, January 25, 2008 January 2008 Update on Feed Enforcement Activities to Limit the Spread of BSE [url=http://madcowspontaneousnot.blogspot.com/2008/01/january-2008-update-on-feed-enforcement.html]http://madcowspontaneousnot.blogspot.co ... ement.html[/url] [url=http://madcowspontaneousnot.blogspot.com/]http://madcowspontaneousnot.blogspot.com/[/url] BSE BASE MAD COW TESTING TEXAS, USA, AND CANADA [url=http://madcowtesting.blogspot.com/]http://madcowtesting.blogspot.com/[/url] NOR-98 ATYPICAL SCRAPIE USA UPDATE AS AT OCT 2007 [url=http://nor-98.blogspot.com/]http://nor-98.blogspot.com/[/url] [url=http://scrapie-usa.blogspot.com/]http://scrapie-usa.blogspot.com/[/url] Terry S. Singeltary Sr. P.O. Box 42 Bacliff, Texas USA 77518 [url=http://cjdmadcowbaseoct2007.blogspot.com/2008/01/evaluation-of-human-transmission-risk.html]http://cjdmadcowbaseoct2007.blogspot.co ... -risk.html[/url] [url=http://cjdmadcowbaseoct2007.blogspot.com/]http://cjdmadcowbaseoct2007.blogspot.com/[/url] TSS [/QUOTE]
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