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Bull with translocation gene, semen testing questions
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<blockquote data-quote="inyati13" data-source="post: 1042067" data-attributes="member: 17767"><p>Kathie: THIS IS NOT AN ANSWER TO YOUR QUESTION. But either you or I do not understand the tranlocation process or maybe both of us don't. Your question seems to imply a misunderstanding. Maybe I am out of line pointing that out. Your question implies that there is a translocator gene that causes translocation. I have researched using google and I cannot find a single reference that implies a so called "translocator gene". I consulted my genetics text. I see those words in the title but I cannot find them any where else. NOT even in the references provided by djinwa. However, I could not open the third reference down. <strong>The term translocated genes is a different meaning.</strong> Yes the genes are "translocated". Translocations occur in the process where egg and sperm are produced, (Robertsonian type translocation). During cell division process (meiosis) that produces in this case sperm, the chromosome pairs line up and separate. When they separate, the limbs of the chromosomes can become broken and get mixed with other chromosomes (translocated). What happens is parts of a chromosome become detached and reunited with non-homologous chromosomes. The resulting zygote that is created by that defective chromosome either goes to term, is born and then becomes a carrier of that defect (translocated series of genes) or it dies and no one ever knows about it occurence. There is no reference to a "translocation gene" that turns this process on and off as one would see in other genetic anomolies. If you look at the first article djinwa put up, it is about as good as I found.</p><p></p><p>As a result, what they are testing is for a set of chromosomes the gene sequence would not be "normal" because it has been translocated. The abnormality djinwa is referring to is a known tranlocation (1;29) which means pieces have been exchanged between the Number 1 and number 29 chromosome (Robertsonian Translocation). </p><p></p><p>BTW, all translocations are almost sure (I say almost to allow for an exception) to affect fertility because a translocation is not normal and has a statictical probability based on that translocation of being abort. There are literial an exponential number of translocations. The semen can be tested for the known translocations but each translocation would require its own test.</p><p></p><p>I know I am a smart azz and that is OK with me but in this case I am sincerely trying although I may be doing a very poor job of pointing out what looks like a misunderstanding in your question. Anyone who can get on here and explain if what I say is correct would absolutely delight me as I also would like to know.</p><p></p><p><em>Is your question, "do semen companies check a bull to determine if he carries a translocation?</em> All translocations will affect fertility to some determined percentage. That I can answer. Please don't get upset. I took a little of your time and it is none of my business but my intentions although maybe misplaced are good. Thanks.</p></blockquote><p></p>
[QUOTE="inyati13, post: 1042067, member: 17767"] Kathie: THIS IS NOT AN ANSWER TO YOUR QUESTION. But either you or I do not understand the tranlocation process or maybe both of us don't. Your question seems to imply a misunderstanding. Maybe I am out of line pointing that out. Your question implies that there is a translocator gene that causes translocation. I have researched using google and I cannot find a single reference that implies a so called "translocator gene". I consulted my genetics text. I see those words in the title but I cannot find them any where else. NOT even in the references provided by djinwa. However, I could not open the third reference down. [b]The term translocated genes is a different meaning.[/b] Yes the genes are "translocated". Translocations occur in the process where egg and sperm are produced, (Robertsonian type translocation). During cell division process (meiosis) that produces in this case sperm, the chromosome pairs line up and separate. When they separate, the limbs of the chromosomes can become broken and get mixed with other chromosomes (translocated). What happens is parts of a chromosome become detached and reunited with non-homologous chromosomes. The resulting zygote that is created by that defective chromosome either goes to term, is born and then becomes a carrier of that defect (translocated series of genes) or it dies and no one ever knows about it occurence. There is no reference to a "translocation gene" that turns this process on and off as one would see in other genetic anomolies. If you look at the first article djinwa put up, it is about as good as I found. As a result, what they are testing is for a set of chromosomes the gene sequence would not be "normal" because it has been translocated. The abnormality djinwa is referring to is a known tranlocation (1;29) which means pieces have been exchanged between the Number 1 and number 29 chromosome (Robertsonian Translocation). BTW, all translocations are almost sure (I say almost to allow for an exception) to affect fertility because a translocation is not normal and has a statictical probability based on that translocation of being abort. There are literial an exponential number of translocations. The semen can be tested for the known translocations but each translocation would require its own test. I know I am a smart azz and that is OK with me but in this case I am sincerely trying although I may be doing a very poor job of pointing out what looks like a misunderstanding in your question. Anyone who can get on here and explain if what I say is correct would absolutely delight me as I also would like to know. [i]Is your question, "do semen companies check a bull to determine if he carries a translocation?[/i] All translocations will affect fertility to some determined percentage. That I can answer. Please don't get upset. I took a little of your time and it is none of my business but my intentions although maybe misplaced are good. Thanks. [/QUOTE]
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