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<blockquote data-quote="Dempster" data-source="post: 1494312" data-attributes="member: 32761"><p>I don't think you can call all that information false. It is very simplistic, but there are not black and white lines with this science. We want to pretend colostral antibodies follow a binary, all here one day and all gone the next time frame. But that simply isn't how they work.</p><p></p><p>Antibodies more closely follow a half-life style of decay. They don't all disappear at the exact same time and they don't slowly taper off at a constant rate. </p><p></p><p>Colostral antiboides should reach their maximum blood levels around 24 hours after birth. Following that, they have a roughly 3 week half life. This means that whatever level of antibodies the blood stream contained at 24 hours, the calf will only have half as many of those original antiboides at 3 weeks. If you wait a second half life (3 more weeks, now 6 total from birth) half of those left after the first 3 weeks will break down and now you have 25% of the antibody remaining. Go to 9 weeks from birth and you are down to 12.5% of the colostral antibodies remaining.</p><p></p><p>Compound on top of that the variability in colostrum quality, variability in time and volume of colostrum uptake, variability in vaccine response in individual cows producing colostrum, etc and you have to quickly conclude there is no right answer. Simply finding a workable answer is a challenge.</p><p></p><p>In companion animals, they work around this by implementing multidose vaccine schedules. Puppies do not receive 3 doses of parvovirus vaccine because it takes that many boosters to develop an immune response, but rather because there is significant variability in when maternal antibody has worn off and the individual pup will be able to mount an immune response. Therefore, they get vaccinated at 6 weeks, and 9 weeks, and 12 weeks with the goal being to develop immunity as soon as possible with the realization that some individuals will take longer than others. If everything was able to mount an immune response at 6 weeks, you would only do that shot with maybe a single booster at some point. But some are not ready until 11 or 12.</p><p></p><p>Cattle work in a similar method. Some calves would likely respond to an injected parenteral IBR vaccine at 3 weeks of age (those calves probably did not get as good of colostrum as they should of). Some calves wont respond until 14 weeks. Each producer needs to determine when they face the greatest risk and work with their veterinarian to develop a vaccine protocol that maximizes vaccine efficacy at that time frame. In some herds, that is going to look like an injectable at 2 months of age during branding. In other herds, there may not be one given until preconditioning at 6 months of age. There is no universal right answer, it's a decision that needs to be made on a herd by herd basis. With all that being said, I still feel like 3 months is a decent point at which to say most cattle will mount a decent response to a 5-way viral. They would certainly do better at 4 months, and better yet at 12 months, but at some point you have to weigh the risks with the benefits and decide what would be best for an individual herd.</p></blockquote><p></p>
[QUOTE="Dempster, post: 1494312, member: 32761"] I don't think you can call all that information false. It is very simplistic, but there are not black and white lines with this science. We want to pretend colostral antibodies follow a binary, all here one day and all gone the next time frame. But that simply isn't how they work. Antibodies more closely follow a half-life style of decay. They don't all disappear at the exact same time and they don't slowly taper off at a constant rate. Colostral antiboides should reach their maximum blood levels around 24 hours after birth. Following that, they have a roughly 3 week half life. This means that whatever level of antibodies the blood stream contained at 24 hours, the calf will only have half as many of those original antiboides at 3 weeks. If you wait a second half life (3 more weeks, now 6 total from birth) half of those left after the first 3 weeks will break down and now you have 25% of the antibody remaining. Go to 9 weeks from birth and you are down to 12.5% of the colostral antibodies remaining. Compound on top of that the variability in colostrum quality, variability in time and volume of colostrum uptake, variability in vaccine response in individual cows producing colostrum, etc and you have to quickly conclude there is no right answer. Simply finding a workable answer is a challenge. In companion animals, they work around this by implementing multidose vaccine schedules. Puppies do not receive 3 doses of parvovirus vaccine because it takes that many boosters to develop an immune response, but rather because there is significant variability in when maternal antibody has worn off and the individual pup will be able to mount an immune response. Therefore, they get vaccinated at 6 weeks, and 9 weeks, and 12 weeks with the goal being to develop immunity as soon as possible with the realization that some individuals will take longer than others. If everything was able to mount an immune response at 6 weeks, you would only do that shot with maybe a single booster at some point. But some are not ready until 11 or 12. Cattle work in a similar method. Some calves would likely respond to an injected parenteral IBR vaccine at 3 weeks of age (those calves probably did not get as good of colostrum as they should of). Some calves wont respond until 14 weeks. Each producer needs to determine when they face the greatest risk and work with their veterinarian to develop a vaccine protocol that maximizes vaccine efficacy at that time frame. In some herds, that is going to look like an injectable at 2 months of age during branding. In other herds, there may not be one given until preconditioning at 6 months of age. There is no universal right answer, it's a decision that needs to be made on a herd by herd basis. With all that being said, I still feel like 3 months is a decent point at which to say most cattle will mount a decent response to a 5-way viral. They would certainly do better at 4 months, and better yet at 12 months, but at some point you have to weigh the risks with the benefits and decide what would be best for an individual herd. [/QUOTE]
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