Greetings,
just what i have been concerned about for years, and what i posted here just last week i.e. 'Friendly Fire', but it was deleted too. but the ramification from this deadly agent via friendly fire is not to be taken lightly. like i said, this goes far far beyond the mad cow hamburger, i.e. secondary transmission via 'friendly fire'. ...TSS
Scientists warn of high rate of vCJD infection via blood
Mon Mar 27, 2006 08:52
70.110.92.4
Subject: Predicting susceptibility and incubation time of human-to-human transmission of vCJD
Date: March 27, 2006 at 6:24 am PST
Lancet Neurology DOI:10.1016/S1474-4422(06)70413-6
Predicting susceptibility and incubation time of human-to-human transmission of vCJD
MT Bishop a, P Hart b, L Aitchison b, HN Baybutt b, C Plinston b, V Thomson b, NL Tuzi b, MW Head a, JW Ironside a, RG Will a and JC Manson b
Summary
Background
Identification of possible transmission of variant Creutzfeldt-Jakob disease (vCJD) via blood transfusion has caused concern over spread of the disease within the human population. We aimed to model iatrogenic spread to enable a comparison of transmission efficiencies of vCJD and bovine spongiform encephalopathy (BSE) and an assessment of the effect of the codon-129 polymorphism on human susceptibility.
Methods
Mice were produced to express human or bovine prion protein (PrP) by direct replacement of the mouse PrP gene. Since the human PrP gene has variation at codon 129, with MM, VV, and MV genotypes, three inbred lines with an identical genetic background were produced to express human PrP with the codon-129 MM, MV, and VV genotypes. Mice were inoculated with BSE or vCJD and assessed for clinical and pathological signs of disease.
Findings
BSE was transmitted to the bovine line but did not transmit to the human lines. By contrast, vCJD was transmitted to all three human lines with different pathological characteristics for each genotype and a gradation of transmission efficiency from MM to MV to VV.
Interpretation
Transmission of BSE to human beings is probably restricted by the presence of a significant species barrier. However, there seems to be a substantially reduced barrier for human-to-human transmission of vCJD. Moreover, all individuals, irrespective of codon-129 genotype, could be susceptible to secondary transmission of vCJD through routes such as blood transfusion. A lengthy preclinical disease is predicted by these models, which may represent a risk for further disease transmission and thus a significant public-health issue.
Affiliations
a. National CJD Surveillance Unit, Bryan Matthews Building, Western General Hospital, Edinburgh, UK
b. Institute for Animal Health, Neuropathogenesis Unit, King's Buildings, Edinburgh, UK
Correspondence to: Prof J C Manson, Institute for Animal Health, Neuropathogenesis Unit, Ogston Building, King's Buildings, West Mains Road, Edinburgh EH9 3JF, UK
http://www.thelancet.com/journals/laneu ... isEOP=true
27 March 2006
Of mice and men... and vCJD
Destination Journal: The Lancet Neurology
Variant Creutzfeldt-Jakob Disease (vCJD) has become a serious public-health concern in Europe, especially in the UK, since it was first described in 1996. This new prion disease in human beings, acquired by ingestion of food contaminated by the bovine spongiform encephalopathy (BSE) agent, has raised new questions not only about food safety, but also about the possibility that human prion diseases could be transmitted from human to human. .....
http://www.thelancet.com/journals/laneu ... isEOP=true
Scientists warn of high rate of vCJD infection
Polly Curtis, health correspondent
Monday March 27, 2006
The Guardian
A "significant level" of the population could be unknowingly infected with variant CJD, according to scientists whose study reveals the disease to be more easily transmitted than previously thought.
http://www.guardian.co.uk/bse/article/0 ... 97,00.html
Scots team finds dormant CJD could emerge to claim many more lives
LOUISE GRAY
New study claims vCJD may lie dormant without symptoms
Disease may also be contracted by blood transfusion
Fears that underlying vCJD may lead to second wave of deaths
Key quote
"You cannot rule out the possibility there may be some effect of BSE on people who have so far shown no effect" - PROF HUGH PENNINGTON
Story in full FAR more people could be at risk of contracting the human form of mad cow disease than previously thought after new evidence emerged that the condition could lie dormant for years before developing.
A long incubation period for the disease, together with an ability to pass it on through blood transfusions and surgical instruments, has the potential to create a "significant public health issue", scientists from Edinburgh said.
http://news.scotsman.com/index.cfm?id=470922006
DAILY TELEGRAPH - More people at risk of vCJD say researchers (27/03/2006)
Many more people may be at risk of contracting Creutzfeldt Jakob Disease (vCJD) than previously thought, according to new research.
http://www.telegraph.co.uk/news/main.jh ... altop.html
THE TIMES - Hidden CJD is new threat to thousands
By Nigel Hawkes, Health Editor
THOUSANDS of people in Britain may be infected with variant CJD, the human equivalent of mad cow disease, without knowing it, research suggests.
http://www.timesonline.co.uk/article/0, ... 95,00.html
THE INDEPENDENT - 'Silent killer vCJD is more widespread than thought'
By Jeremy Laurance, Health Editor, 27 March 2006
The incurable brain disease vCJD, the human form of BSE (mad cow disease), may be widespread and advancing undetected, scientists say.
http://news.independent.co.uk/uk/health ... 353862.ece
BBC - vCJD transmission 'risk for all'
Everyone could be susceptible to vCJD infection via blood transfusions but their genes could determine how it will affect them, a study suggests.
http://news.bbc.co.uk/2/hi/health/4841078.stm
TSS
just what i have been concerned about for years, and what i posted here just last week i.e. 'Friendly Fire', but it was deleted too. but the ramification from this deadly agent via friendly fire is not to be taken lightly. like i said, this goes far far beyond the mad cow hamburger, i.e. secondary transmission via 'friendly fire'. ...TSS
Scientists warn of high rate of vCJD infection via blood
Mon Mar 27, 2006 08:52
70.110.92.4
Subject: Predicting susceptibility and incubation time of human-to-human transmission of vCJD
Date: March 27, 2006 at 6:24 am PST
Lancet Neurology DOI:10.1016/S1474-4422(06)70413-6
Predicting susceptibility and incubation time of human-to-human transmission of vCJD
MT Bishop a, P Hart b, L Aitchison b, HN Baybutt b, C Plinston b, V Thomson b, NL Tuzi b, MW Head a, JW Ironside a, RG Will a and JC Manson b
Summary
Background
Identification of possible transmission of variant Creutzfeldt-Jakob disease (vCJD) via blood transfusion has caused concern over spread of the disease within the human population. We aimed to model iatrogenic spread to enable a comparison of transmission efficiencies of vCJD and bovine spongiform encephalopathy (BSE) and an assessment of the effect of the codon-129 polymorphism on human susceptibility.
Methods
Mice were produced to express human or bovine prion protein (PrP) by direct replacement of the mouse PrP gene. Since the human PrP gene has variation at codon 129, with MM, VV, and MV genotypes, three inbred lines with an identical genetic background were produced to express human PrP with the codon-129 MM, MV, and VV genotypes. Mice were inoculated with BSE or vCJD and assessed for clinical and pathological signs of disease.
Findings
BSE was transmitted to the bovine line but did not transmit to the human lines. By contrast, vCJD was transmitted to all three human lines with different pathological characteristics for each genotype and a gradation of transmission efficiency from MM to MV to VV.
Interpretation
Transmission of BSE to human beings is probably restricted by the presence of a significant species barrier. However, there seems to be a substantially reduced barrier for human-to-human transmission of vCJD. Moreover, all individuals, irrespective of codon-129 genotype, could be susceptible to secondary transmission of vCJD through routes such as blood transfusion. A lengthy preclinical disease is predicted by these models, which may represent a risk for further disease transmission and thus a significant public-health issue.
Affiliations
a. National CJD Surveillance Unit, Bryan Matthews Building, Western General Hospital, Edinburgh, UK
b. Institute for Animal Health, Neuropathogenesis Unit, King's Buildings, Edinburgh, UK
Correspondence to: Prof J C Manson, Institute for Animal Health, Neuropathogenesis Unit, Ogston Building, King's Buildings, West Mains Road, Edinburgh EH9 3JF, UK
http://www.thelancet.com/journals/laneu ... isEOP=true
27 March 2006
Of mice and men... and vCJD
Destination Journal: The Lancet Neurology
Variant Creutzfeldt-Jakob Disease (vCJD) has become a serious public-health concern in Europe, especially in the UK, since it was first described in 1996. This new prion disease in human beings, acquired by ingestion of food contaminated by the bovine spongiform encephalopathy (BSE) agent, has raised new questions not only about food safety, but also about the possibility that human prion diseases could be transmitted from human to human. .....
http://www.thelancet.com/journals/laneu ... isEOP=true
Scientists warn of high rate of vCJD infection
Polly Curtis, health correspondent
Monday March 27, 2006
The Guardian
A "significant level" of the population could be unknowingly infected with variant CJD, according to scientists whose study reveals the disease to be more easily transmitted than previously thought.
http://www.guardian.co.uk/bse/article/0 ... 97,00.html
Scots team finds dormant CJD could emerge to claim many more lives
LOUISE GRAY
New study claims vCJD may lie dormant without symptoms
Disease may also be contracted by blood transfusion
Fears that underlying vCJD may lead to second wave of deaths
Key quote
"You cannot rule out the possibility there may be some effect of BSE on people who have so far shown no effect" - PROF HUGH PENNINGTON
Story in full FAR more people could be at risk of contracting the human form of mad cow disease than previously thought after new evidence emerged that the condition could lie dormant for years before developing.
A long incubation period for the disease, together with an ability to pass it on through blood transfusions and surgical instruments, has the potential to create a "significant public health issue", scientists from Edinburgh said.
http://news.scotsman.com/index.cfm?id=470922006
DAILY TELEGRAPH - More people at risk of vCJD say researchers (27/03/2006)
Many more people may be at risk of contracting Creutzfeldt Jakob Disease (vCJD) than previously thought, according to new research.
http://www.telegraph.co.uk/news/main.jh ... altop.html
THE TIMES - Hidden CJD is new threat to thousands
By Nigel Hawkes, Health Editor
THOUSANDS of people in Britain may be infected with variant CJD, the human equivalent of mad cow disease, without knowing it, research suggests.
http://www.timesonline.co.uk/article/0, ... 95,00.html
THE INDEPENDENT - 'Silent killer vCJD is more widespread than thought'
By Jeremy Laurance, Health Editor, 27 March 2006
The incurable brain disease vCJD, the human form of BSE (mad cow disease), may be widespread and advancing undetected, scientists say.
http://news.independent.co.uk/uk/health ... 353862.ece
BBC - vCJD transmission 'risk for all'
Everyone could be susceptible to vCJD infection via blood transfusions but their genes could determine how it will affect them, a study suggests.
http://news.bbc.co.uk/2/hi/health/4841078.stm
TSS