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Need Help--Staggering, Paralysis due to Dewormer??
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<blockquote data-quote="Anonymous" data-source="post: 10444"><p>All avermectins can cause this reaction from two reasons. The first and most obvious is that if a parasite dies in the Central Nervous System or spinal canal, the resultant reaction to the dead parasite will cause staggering or paralysis. This isn't reversable, however steroids will minimize the reaction and you may get a functional animal, albeit a bit different. The second and less obvious reason is that the avermectins (which ivermectin is a member) are GABA inhibitors. This is a neurotransmitter which is at much higher levels in insects than mammals. Certain animals--collies, oesd's, etc have an increased sensitivity to these products, and can become toxic at what is safe in most animals. IF your bull was either overdosed or happens to be sensitive, supportive care will get him through, though it will take about a week at least.</p><p></p><p>My problem with Hypoderma bovis dying in the spinal canal at this time is that it only usually occurs after Dec 15 or so....thus the label says Dec. 1st, and it must be the eastern part of the country, since the western warble will cause choking, not downers....does this muddy or clarify things for you? Good Luck! V</p></blockquote><p></p>
[QUOTE="Anonymous, post: 10444"] All avermectins can cause this reaction from two reasons. The first and most obvious is that if a parasite dies in the Central Nervous System or spinal canal, the resultant reaction to the dead parasite will cause staggering or paralysis. This isn't reversable, however steroids will minimize the reaction and you may get a functional animal, albeit a bit different. The second and less obvious reason is that the avermectins (which ivermectin is a member) are GABA inhibitors. This is a neurotransmitter which is at much higher levels in insects than mammals. Certain animals--collies, oesd's, etc have an increased sensitivity to these products, and can become toxic at what is safe in most animals. IF your bull was either overdosed or happens to be sensitive, supportive care will get him through, though it will take about a week at least. My problem with Hypoderma bovis dying in the spinal canal at this time is that it only usually occurs after Dec 15 or so....thus the label says Dec. 1st, and it must be the eastern part of the country, since the western warble will cause choking, not downers....does this muddy or clarify things for you? Good Luck! V [/QUOTE]
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Need Help--Staggering, Paralysis due to Dewormer??
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