Excede Withdrawal

[dt34715]

I recently gave a 3 year old cow a shot of excede per vet instructions. I was told to put in under the skin by the vet which I did, in the neck. Later I find out it should have been behind the ear.
How long before I can sell this cow?

 

[kenny thomas]

It normally has a 13 day withdrawl but im not sure if the location change makes a difference. I have used it in a dart, with Vets consultation, so it wasnt behind the ear there either.

 

[simme]

Giving it in the neck is an extra-label use since the label specifically says to not give it in the neck. My suggestion is to first call the manufacturer Zoetis at 888-963-8471 and ask them for advice/guidance. I think they will be helpful.

If that phone call does not give the answer, contact your vet for guidance. There is a government agency that will calculate a withdrawal time for extra label drug use. I think it is FARAD (Food Animal Residue Avoidance Databank). The veterinarian must make the request. They will give a calculated extended withdrawal time to the vet. It will probably be a long time. Enough to avoid the cow testing positive for drug residue if she goes to slaughter.

ELDU and Withdrawal Time | FARAD

How drug residues and withdrawal times are affected with extra-label drug use (ELDU) in Food Animals

www.farad.org

The Ins and Outs of Extra-Label Drug Use in Animals

An explanation for veterinarians of FDA’s requirements for extra-label drug use in animals.

www.fda.gov

 

[kenny thomas]

Giving it in the neck is an extra-label use since the label specifically says to not give it in the neck. My suggestion is to first call the manufacturer Zoetis at 888-963-8471 and ask them for advice/guidance. I think they will be helpful.

If that phone call does not give the answer, contact your vet for guidance. There is a government agency that will calculate a withdrawal time for extra label drug use. I think it is FARAD (Food Animal Residue Avoidance Databank). The veterinarian must make the request. They will give a calculated extended withdrawal time to the vet. It will probably be a long time. Enough to avoid the cow testing positive for drug residue if she goes to slaughter.

ELDU and Withdrawal Time | FARAD

How drug residues and withdrawal times are affected with extra-label drug use (ELDU) in Food Animals

www.farad.org

The Ins and Outs of Extra-Label Drug Use in Animals

An explanation for veterinarians of FDA’s requirements for extra-label drug use in animals.

www.fda.gov

Very good advice. The extra label use is by vet approval only. The couple i used a dart on were 4wts and a year or more from slaughter. They definitely do a lot more testing now.

 

[simme]

Note that there are some drugs that never qualify for extra label drug use in food animals. No veterinarian or any other person can justify their use. Illegal for anyone to give them. Here is the list:

• Chloramphenicol
• Clenbuterol
• Diethylstilbestrol (DES)
• Dimetridazole
• Ipronidazole and other nitroimidazoles
• Furazolidone and nitrofurazone
• Sulfonamide drugs in lactating dairy cattle, except for the approved use of sulfadimethoxine, sulfabromomethazine, and sulfaethoxypyridazine
• Fluoroquinolones
• Glycopeptides
• Phenylbutazone in female dairy cattle 20 months of age or older
• Cephalosporins (not including cephapirin) in cattle, swine, chickens, or turkeys:
  • For disease prevention purposes;
  • At unapproved doses, frequencies, durations, or routes of administration; or
  • If the drug is not approved for that species and production class.

Some of those might sound familiar. Furazolidone and nitrofurazone were the powdered drugs in the puffer bottles or aerosol cans used to treat pinkeye until about 20 years ago. One brand name was Furox.

Diethylstilbestrol (estrogen) was used as a growth implant starting in the 1950's. Banned in cattle in the early 70's. Other growth implants were then marketed.

Phenylbutazone is Bute - not allowed in dairy cattle at 20 months of age.

Most recognized fluoroquinolone is Cipro. Still used in people but removed from food animal use due to antibiotic resistance concern in poultry.

And not a technically a drug, but Koper-tox is allowed for horses, but not for food animals.

 

[kenny thomas]

Wasn't Koper-tox widely used on foot rot, especially in sheep and goats?

 

[simme]

Wasn't Koper-tox widely used on foot rot, especially in sheep and goats?

Yes. And still is maybe, but not supposed to be for food animals.

 

[SBMF 2015]

Note that there are some drugs that never qualify for extra label drug use in food animals. No veterinarian or any other person can justify their use. Illegal for anyone to give them. Here is the list:

• Chloramphenicol
• Clenbuterol
• Diethylstilbestrol (DES)
• Dimetridazole
• Ipronidazole and other nitroimidazoles
• Furazolidone and nitrofurazone
• Sulfonamide drugs in lactating dairy cattle, except for the approved use of sulfadimethoxine, sulfabromomethazine, and sulfaethoxypyridazine
• Fluoroquinolones
• Glycopeptides
• Phenylbutazone in female dairy cattle 20 months of age or older
• Cephalosporins (not including cephapirin) in cattle, swine, chickens, or turkeys:
  • For disease prevention purposes;
  • At unapproved doses, frequencies, durations, or routes of administration; or
  • If the drug is not approved for that species and production class.

Some of those might sound familiar. Furazolidone and nitrofurazone were the powdered drugs in the puffer bottles or aerosol cans used to treat pinkeye until about 20 years ago. One brand name was Furox.

Diethylstilbestrol (estrogen) was used as a growth implant starting in the 1950's. Banned in cattle in the early 70's. Other growth implants were then marketed.

Phenylbutazone is Bute - not allowed in dairy cattle at 20 months of age.

Most recognized fluoroquinolone is Cipro. Still used in people but removed from food animal use due to antibiotic resistance concern in poultry.

And not a technically a drug, but Koper-tox is allowed for horses, but not for food animal.

Gentamicin Sulfate.
I had a state vet tell me that if I had to beef test positive at the plant the first thing they would do is contact me, find out who the vet was that prescribed it and pull their license.

 

[simme]

Gentamicin Sulfate.
I had a state vet tell me that if I had to beef test positive at the plant the first thing they would do is contact me, find out who the vet was that prescribed it and pull their license.

From the AVMA (american veterinary medical association) - "In addition, the FDA has not approved gentamicin for use in cattle or scientifically established a withdrawal time for cattle. While the Food Animal Residue Avoidance Databank recommends a minimum preslaughter withdrawal period of 18 months or more for this drug, the AVMA and American Association of Bovine Practitioners have called on veterinarians to avoid extralabel use of aminoglycosides, including gentamicin, in cattle, because of the propensity for these drugs to be retained in kidney tissue for long periods."

18 months minimum withdrawal time - how likely is that to happen? Some vets are pretty lenient with the rules when their customers request/demand a certain medication they think they need/deserve. And customers can get pretty irate if their demand is not met. But loss of vet license will surely affect a vet's income.

 

[wbvs58]

Usually the main reason for the recommendation behind the ear is because it is irritant and may produce a lump so the hide is not spoilt. The ears come off with the head.

Ken