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Double Muscled?
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<blockquote data-quote="knabe" data-source="post: 628791" data-attributes="member: 6727"><p>there are at least 5 double muscling mutations</p><p></p><p>Piedmontese have one version and there is a commercial test for it.</p><p></p><p>parthenaise 100 years ago refers to several breeds of cattle, which include mancelle, forerunner to fullblood maine's. maine's today have two different mutations.</p><p></p><p>the entire gene has been sequenced a few years ago. it's pretty easy to google.</p><p></p><p>there is a theory that one version of double muscling may involve a duplication, and therefore, only one arm of the chromosome is necessary for double muscling to manifest itself. that means you don't need a copy from the mother AND the father. not proven yet, but totally possible as similar things happen in other genes. usually when you have a duplication, one of them is silenced by methylation.</p><p></p><p>here's an interesting take on a heterozygote form in dogs</p><p></p><p><a href="http://www.plosgenetics.org/article/info:doi%2F10.1371%2Fjournal.pgen.0030079" target="_blank">http://www.plosgenetics.org/article/inf ... en.0030079</a></p><p></p><p>what would be a bummer is if maine's historic thickness was due to the heterozygous state of both mutations. even one would be a bummer. maine sires with double muscling are pretty well known.</p></blockquote><p></p>
[QUOTE="knabe, post: 628791, member: 6727"] there are at least 5 double muscling mutations Piedmontese have one version and there is a commercial test for it. parthenaise 100 years ago refers to several breeds of cattle, which include mancelle, forerunner to fullblood maine's. maine's today have two different mutations. the entire gene has been sequenced a few years ago. it's pretty easy to google. there is a theory that one version of double muscling may involve a duplication, and therefore, only one arm of the chromosome is necessary for double muscling to manifest itself. that means you don't need a copy from the mother AND the father. not proven yet, but totally possible as similar things happen in other genes. usually when you have a duplication, one of them is silenced by methylation. here's an interesting take on a heterozygote form in dogs [url=http://www.plosgenetics.org/article/info:doi%2F10.1371%2Fjournal.pgen.0030079]http://www.plosgenetics.org/article/inf ... en.0030079[/url] what would be a bummer is if maine's historic thickness was due to the heterozygous state of both mutations. even one would be a bummer. maine sires with double muscling are pretty well known. [/QUOTE]
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