We run a substantial herd with an extensive vaccination program. We vaccinated for pink-eye yet still wind up with four or five cases each year. I used to use 1/2 cc PreDef with 1/2 cc Oxytet in the eyelid and it always did a great job at clearing it up. We also keep detailed records. We usually have about 60 - 80 replacement heifers a year. About 4 - 5 of those wind up open each year and get shipped, but I noticed while reviewing records that for two years in a row, every open heifer was doctored for pink-eye as a calf. I asked our vet if there was any correlation with PreDef as it appears to be the common denominator. He was sure it was just coincidence or some other issue such as a compromised immune system (maybe lack of colostrum as a calf) that was a factor in both issues. Since then we switched to Dexameth plus Oxytet just as a precaution (works good also). Don't have history yet to see if it made a difference, but I was wondering if anyone out there had any similar experiences??