83 days to the Super Bowl in Minnesota

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How to Get an A- in Organic Chemistry
By BARBARA MORANNOV. 1, 2013

THE molecule looked like a giant jellyfish. Or maybe a spider. Halfway through my organic chemistry final, the monster lay there on the page, mocking me. My task: explain how the ungainly molecule folds into a tidy package. The problem: I had no clue. Maybe if I looked at it sideways? No, that didn't help. This was getting ugly.

Contemplating a midlife career change from science writer to doctor, I spent eight months last year at Harvard Extension School slogging through two semesters of organic chemistry, or orgo, the course widely known for weeding out pre-meds. At 42, I was an anomaly, older than most of my classmates (and both professors), out of college for two decades and with two small children. When I wasn't hopelessly confused, I spent my time wondering what the class was actually about. Because I'm pretty sure it wasn't just about organic chemistry. For me, the overriding question was not "Is this on the test?" but rather "What are they really testing?"

Orgo has been haunting pre-meds since 1910, when the Carnegie Foundation for the Advancement of Teaching released a landmark report calling for tougher admission standards to medical school and for medical training based on science. Hence emerged science prerequisites that have remained virtually unchanged: two semesters each of biology, physics and general and organic chemistry.

The report was meant to professionalize medicine but led to generations of doctors more grounded in science than in the humanities. This is not necessarily bad, but lately a sense has emerged that the pendulum has swung too far. Medical schools are tweaking admission protocols, looking beyond an A in orgo for future doctors who are less Spock and more Kirk.

I asked two medical school deans — Dr. Robert Witzburg at Boston University and Dr. Lee Goldman at Columbia University — about admission philosophies. Both are proponents of holistic review, the newish idea that medical schools look beyond grades and test scores to evaluate the whole applicant. "We have to find people who can do both the personal and the scientific," Dr. Goldman said. But both also emphasized the continued importance of orgo, not because doctors actually use it but because it lays the groundwork for biochemistry and pharmacology.


In 2015, the Medical College Admission Test will change, with added sections on social science, psychology and ethics, but sorry, orgo will remain prominent. "The organic chemistry on the MCAT is chemistry that students need to know to succeed in medical school," said Karen Mitchell, senior director of the MCAT Program.

So what is organic chemistry, anyway? And why is it so difficult? Basically, orgo examines how molecules containing carbon interact, but it doesn't require equations or math, as in physics. Instead, you learn how electrons flow around and between molecules, and you draw little curved arrows showing where they go. This "arrow pushing" is the heart and soul of orgo. Figure 1 (pictured above left) shows the arrow pushing mechanism for a simple reaction, adding acidified water (H3O+) to a carbon molecule called an alkene (don't worry, this is all the orgo you'll have to learn).

Learning how to interpret the hieroglyphics is pretty easy. The hard part is learning where to draw the little arrows. To do this, you learn rules about how molecules behave. For instance, in the third step of the drawing above, you can see an arrow pointing from the "O" (oxygen) of OH2 to a plus sign (a positive charge). This means oxygen is donating electrons to a positively charged carbon atom. After you draw oxygen donating electrons to a positive carbon a zillion times, it becomes second nature. An arrow pointing from a plus sign toward oxygen then seems viscerally wrong, like ketchup on sushi.

But the rules have many, many exceptions, which students find maddening. The same molecule will behave differently in acid or base, in dark or sunlight, in heat or cold, or if you sprinkle magic orgo dust on it and turn around three times. You can't memorize all the possible answers — you have to rely on intuition, generalizing from specific examples. This skill, far more than the details of every reaction, may actually be useful for medicine.

"It seems a lot like diagnosis," said Logan McCarty, Harvard's director of physical sciences education, who taught the second semester. "That cognitive skill — inductive generalization from specific cases to something you've never seen before — that's something you learn in orgo."

To develop orgo intuition, you solve problems and draw arrow-pushing mechanisms again and again, until they become instinctive. This takes a huge amount of time, for me 20 to 30 hours a week. The class turned me into a bore, a sleep-deprived, orgo-obsessed grind who saw the shapes of molecules in every sidewalk crack and snack cracker.

My study partners and I called orgo the "bad boyfriend," because it stole so much time from our personal lives. As in, "I just blew off Thanksgiving dinner to hang out with the bad boyfriend." Once, my 3-year-old clung to my leg as I tried to leave for class. "Mama, don't go!" he cried. "No more chemistry!" Sorry, little buddy. Bad boyfriend's calling.

This is one thing that orgo is testing: whether you have the time and desire to do the work. "Sometimes, if a student has really good math skills, they can slide through physics, but you can't do that in orgo," Mr. McCarty told me, adding, "You can't slide through medical school, either."

At first, this commitment of time and psyche did not pay off. On the first exam I scored well below the mean. My problem sets came back with whole pages slashed out in red pen. I felt stupid and demoralized. But slowly, orgo awakened my long-dormant spatial-reasoning skills, and I (occasionally) started to enjoy some of the problems.

Second semester, I had a breakthrough. On the third exam, stuck halfway through the final problem, I tried a new strategy. I put down my pencil, leaned back and stopped thinking. For a moment, nothing happened. Then the answer sprang into my mind's eye. "Oh, my God!" I thought. "I actually have orgo instinct!" After that, everything started clicking.

When the final exam came, I was ready. I chugged through the first few pages, then stopped. There lay the giant jellyfish-spider, streaming carbon chains like tentacles. Draw the arrows? I didn't even know where to start. Next problem, just as bad. The test became not a showcase of my new orgo instinct but a scramble for damage control. I guessed I got a C.

When the test ended, the students sat stunned. "What was that?" my study partner asked. "A monkey could have done better on that exam than me." Later, in the bathroom, one of our classmates sobbed as another consoled her.

The day after the final, a physician friend gave me a celebratory gift: a stethoscope. I told her about the exam, and she nodded. "That's a terrible feeling," she agreed. "It's kind of how you feel when you lose your first patient."

Of course, bombing a test isn't the same as watching someone die. But what's similar is that dreadful realization of your own limits, that terrible moment when you stop controlling the situation and start mitigating the damage. I expect that's an all-too-common feeling in medicine. I often felt that way in orgo, but kept going back for more. That's what orgo is testing, I think: resilience. And humility.

I got a B on the final, by the way. Grade for the class: A-.

Barbara Moran is a science writer and in pre-med at Harvard Extension School.
 
Son of Butch":bz2vvn63 said:
I'm thinking the Rams are a year away from being a legit threat. They'll be tested here Sunday.
In any event their head coach should be the front runner for coach of the year.
66 days to the Super Bowl
Case Keenum and the Vikings will be tested in Atlanta today to see if they deserve being mentioned along with
Carson Wentz and the Eagles as being the NFC's best.
 
haase":2sig4vlg said:
Looks like the packers might be done, so I'm pulling for the Vikings.
I don't know. They have the Browns this weekend and Carolina the next. A couple places I've seen today are saying Rodgers could be back by week 15. The last two games are Vikings and Lions. So, the last four games are looking like three decently difficult games and a patsy. But if Rodgers comes back, all bets are off and the Pack could be back!
 
Son of Butch":222eebhx said:
Son of Butch":222eebhx said:
I'm thinking the Rams are a year away from being a legit threat. They'll be tested here Sunday.
In any event their head coach should be the front runner for coach of the year.
66 days to the Super Bowl
Case Keenum and the Vikings will be tested in Atlanta today to see if they deserve being mentioned along with
Carson Wentz and the Eagles as being the NFC's best.

Again Keenum rises to the top.
The idiot O'Brien at Houston couldn't keep him and build a team because he was a Kubiak pick.
Again I have been a Keenum fan since U of H days.
Houston is too stupid to learn the running or passing game only works behind the O line.
 
I think Rodgers has to wait until week 16 with the NFLs new ir rule, I know he practiced this week,and wants to play against the Vikings, not sure if that's a good idea or just let it heal and comeback next year.
 
NFL starting QBs average 13.5 million per year
Vikings signed Keenum to 1 year 2 million contract which may have been top money for a back up at the time,
but I'm sure they're wishing now to have included a team option to renew for 3 million rather than allowing him
to become a free agent in March. He's in for a big payday somewhere... hope it's with the Vikings.
 
Son of Butch":1528nbfb said:
NFL starting QBs average 13.5 million per year
Vikings signed Keenum to 1 year 2 million contract which may have been top money for a back up at the time,
but I'm sure they're wishing now to have included a team option to renew for 3 million rather than allowing him
to become a free agent in March. He's in for a big payday somewhere... hope it's with the Vikings.

Sounds like they thought he was a temp until Teddy came off the IR. Better to be lucky than good...

What will it cost me to watch the Vikings at the Super Bowl?
 
Stocker Steve":b6ledhpe said:
Son of Butch":b6ledhpe said:
NFL starting QBs average 13.5 million per year
Vikings signed Keenum to 1 year 2 million contract which may have been top money for a back up at the time,
but I'm sure they're wishing now to have included a team option to renew for 3 million rather than allowing him
to become a free agent in March. He's in for a big payday somewhere... hope it's with the Vikings.

Sounds like they thought he was a temp until Teddy came off the IR. Better to be lucky than good...

What will it cost me to watch the Vikings at the Super Bowl?

He's good he still holds the record for passing yards.

https://en.m.wikipedia.org/wiki/Case_Keenum
 
Keenum has had a decent year, hope he's not a flash in the pan, have seen this happen a few times before, remember Matt Flynn, haven't heard about him in a while.
 
Caustic Burno":2oddzdms said:
Son of Butch":2oddzdms said:
Son of Butch":2oddzdms said:
I'm thinking the Rams are a year away from being a legit threat. They'll be tested here Sunday.
In any event their head coach should be the front runner for coach of the year.
66 days to the Super Bowl
Case Keenum and the Vikings will be tested in Atlanta today to see if they deserve being mentioned along with
Carson Wentz and the Eagles as being the NFC's best.
(Vikings won at Atlanta 14-9)
Again Keenum rises to the top.
I have been a Keenum fan since U of H days.
Houston is too stupid to learn the running or passing game only works behind the O line.

What a difference a season makes. (except for Houston)
Last year Rams lost to Vikings 16-7
Rams not only the team to beat in the NFC this season, but have replaced Philly as legit threat to win the Super Bowl?
Vikings are a mess right now, O-line as bad as any in NFL, defensive depth has been exposed and up next at Philly.
 
Son of Butch":lx0ng9x0 said:
What a difference a season makes. (except for Houston)
Last year Rams lost to Vikings 16-7
Rams not only the team to beat in the NFC this season, but have replaced Philly as legit threat to win the Super Bowl?
Vikings are a mess right now, O-line as bad as any in NFL, defensive depth has been exposed and up next at Philly.
Well, I guess someone has to provide some stability to the universe.
Week 4 power rankings had Houston #28 or 29. How an 0-3 team (Hou) can be ranked above a 1-2 team (Bills) is puzzling....
 
greybeard":qkmupw5q said:
Son of Butch":qkmupw5q said:
What a difference a season makes. (except for Houston)
Last year Rams lost to Vikings 16-7
Rams not only the team to beat in the NFC this season, but have replaced Philly as legit threat to win the Super Bowl?
Vikings are a mess right now, O-line as bad as any in NFL, defensive depth has been exposed and up next at Philly.
Well, I guess someone has to provide some stability to the universe.
Week 4 power rankings had Houston #28 or 29. How an 0-3 team (Hou) can be ranked above a 1-2 team (Bills) is puzzling....


Houston needs two things a good GM and head coach. Never been an OBrien fan. If my dumb butt sitting in a recliner can call most of their next plays makes it easy pickens for the other teams.
Again Houston couldn't find a franchise QB if one dropped through the roof of Reliant Stadium. Hope I am wrong IMO Wastson is headed down the RG3 road.
That style of QB doesn't have a long life expectancy in the NFL.
 
Caustic Burno":a8hwfup1 said:
Hope I am wrong IMO Watson is headed down the RG3 road. That style of QB doesn't have a long life expectancy
in the NFL.
Yep
Young QB that takes off running can be very effective for a season or 2 but history has shown they have a short shelf life as the hits pile up taking their toll.

Da Bears look like they are a QB away from being a serious threat. They've put together a top notch defense.
Which should take the pressure off Mitch Trubisky giving them time for him to develop into an NFL qb.
Remains to be seen if he can do it, but a top defense can cover a multitude of errors.
 
If the Minneapolis police don't stop shooting folks every time they hear a noise that startled them, then nobody is gonna want to go to Minnesota for the Super Bowl :hide:

Imagine the February 2019 headlines:

SUPER BOWL SPECTATOR DEAD
35 time super bowl mvp quarterback Brett Favre shot behind the ear by a policeman after he allegedly took a bite out of a extra crunchy super bowl Dorito which startled the officer who reacted overzealously. Favre was found to not be packing any weapon, only a half eaten back of ranch Doritos. But is dead nonetheless. The officer is now on desk duty pending a promotion to traffic duty. He was allowed to keep his firearm. :lol2:

Forgive me. I know this was wrong.
 
That's right.... the 2019 Super Bowl will be in Atlanta, Georgia. (danger, Will Robinson, danger, danger)

In Minnesota they only shoot complaining women and other dangerous foreigners from shxthole countries like Australia.
:frowns:
 
Son of Butch":1ea8s581 said:
That's right.... the 2019 Super Bowl will be in Atlanta, Georgia. (danger, Will Robinson, danger, danger)

In Minnesota they only shoot complaining women and other dangerous foreigners from shxthole countries like Australia.
:frowns:
150,000 muslims must be off limits.
 

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